The Moscone Center
San Francisco, California, United States
27 January - 1 February 2018
Conference 10478
Molecular-Guided Surgery: Molecules, Devices, and Applications IV
Saturday - Sunday 27 - 28 January 2018
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Program Committee continued...
Saturday 27 January Show All Abstracts
Session 1:
Advanced Detection Methods I
Saturday 27 January 2018
8:15 AM - 10:00 AM
Location: Room 3006 (West Level 3)
Session Chairs:
Frédéric Leblond, Ecole Polytechnique de Montréal (Canada) ;
Nils Petitdidier, CEA-LETI (France)
Slide-free molecular pathology with in vivo dual-axis confocal and ex vivo light-sheet microscopy (Invited Paper)
Paper 10478-1
Time: 8:15 AM - 8:45 AM
Author(s): Jonathan T. C. Liu, Univ. of Washington (United States)
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Static and dynamic full field OCT: an endogenous biomaker? (Invited Paper)
Paper 10478-2
Time: 8:45 AM - 9:15 AM
Author(s): Albert Claude Boccara, Institut Langevin (France); Clement Apelian, LLTech SAS (France), Institut Langevin (France); Emilie Benoit a la Guillaume, Alban Mounier, Eugénie Dalimier, LLTech SAS (France)
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Optimizing fluorescently-tethered Hsp90 inhibitor dose for maximal specific uptake by breast tumors
Paper 10478-3
Time: 9:15 AM - 9:30 AM
Author(s): Brian Crouch, Jennifer Gallagher, Allison Hall, Mary Scott Soo, Duke Univ. (United States); Philip Hughes, Timothy Haystead, Duke Univ. School of Medicine (United States); Nimmi Ramanujam, Duke Univ. (United States)
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Intraoperative determination of tumor aggressiveness by real-time label-free nonlinear imaging and characterization of tumor-associated extracellular vesicles
Paper 10478-4
Time: 9:30 AM - 9:45 AM
Author(s): Yi Sun, Sixian You, Haohua Tu, Darold R. Spillman, Marina Marjanovic, Eric J. Chaney, Univ. of Illinois (United States); George Z. Liu, Anna Higham, Kimberly A. Cradock, Carle Foundation Hospital (United States); Stephen A. Boppart, Univ. of Illinois (United States)
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Raman spectroscopic analysis for gastric and colorectal cancer in surgical treatment toward molecular-guided surgery
Paper 10478-5
Time: 9:45 AM - 10:00 AM
Author(s): Shigehiro Koga, Yuji Watanabe, Yusuke Oshima, Ehime Univ. (Japan)
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Coffee Break 10:00 AM - 10:30 AM
Session 2:
Advanced Detection Methods II
Saturday 27 January 2018
10:30 AM - 12:15 PM
Location: Room 3006 (West Level 3)
Session Chairs:
Nicholas J. Durr, Johns Hopkins Univ. (United States) ;
Jonathan T.C. Liu, Univ. of Washington (United States)
Polarization- and wavelength-resolved imaging with standard laparoscopes (Invited Paper)
Paper 10478-6
Time: 10:30 AM - 11:00 AM
Author(s): Daniel S. Elson, Imperial College London (United Kingdom)
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Label-free optical spectroscopy techniques for targeted, real time and informed in situ cancer diagnosis (Invited Paper)
Paper 10478-7
Time: 11:00 AM - 11:30 AM
Author(s): Frédéric Leblond, Ecole Polytechnique de Montréal (Canada)
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Optimization of the incident wavelength in Mueller Matrix imaging of cervical collagen
Paper 10478-8
Time: 11:30 AM - 11:45 AM
Author(s): Joseph Chue-Sang, Florida International Univ. (United States)
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Fluorescence lifetime-based contrast enhancement of Indocyanine green-labelled tumors
Paper 10478-9
Time: 11:45 AM - 12:00 PM
Author(s): Anand T. Kumar, Stefan Carp, Massachusetts General Hospital (United States)
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Fluorescence detection and enumeration of rare circulating cells in vivo
Paper 10478-10
Time: 12:00 PM - 12:15 PM
Author(s): Xuefei Tan, Roshani A. Patil, Northeastern Univ. (United States); Judith M. Runnels, Charles P. Lin, Massachusetts General Hospital (United States); Mark Niedre, Northeastern Univ. (United States)
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Lunch/Exhibition Break 12:15 PM - 1:45 PM
Session 3:
Imaging Systems
Saturday 27 January 2018
1:45 PM - 3:15 PM
Location: Room 3006 (West Level 3)
Session Chairs:
Jana M. Kainerstorfer, Carnegie Mellon Univ. (United States) ;
Daniel S. Elson, Imperial College London (United Kingdom)
Real-time quantitative optical imaging for surgical guidance (Invited Paper)
Paper 10478-11
Time: 1:45 PM - 2:15 PM
Author(s): Sylvain Gioux, Univ. de Strasbourg (France)
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Bio-inspired near infrared fluorescence sensors: from the ocean to the operating room (Invited Paper)
Paper 10478-12
Time: 2:15 PM - 2:45 PM
Author(s): Viktor Gruev, Missael Garcia, Nan Cui, Qinru Li, Univ. of Illinois (United States)
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Handheld dual-modality wide-field fluorescent imaging guided dual-axis confocal microscope for fluorescence molecular guidance of precise tumor resection in head and neck surgery
Paper 10478-15
Time: 2:45 PM - 3:00 PM
Author(s): Zhen Qiu, Institute of Quantitative Health Science and Engineering, Michigan State Univ. (United States); Tarn Teraphongphom, Nynke S. van den Berg, Nathan O. Loewke, Guolan Lu, Robert Ertsey, Frank Schonig, Stephan Rogalla, Shai Friedland, Michael J. Mandella, Eben L. Rosenthal, Stanford Univ. (United States); Christopher H. Contag, Institute of Quantitative Health Science and Engineering, Michigan State Univ. (United States)
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Hexachromatic imager for near-infrared fluorescence image-guided surgery
Paper 10478-16
Time: 3:00 PM - 3:15 PM
Author(s): Missael Garcia, Washington Univ. in St. Louis (United States), Univ. of Illinois (United States); Viktor Gruev, Univ. of Illinois (United States); Radoslav Marinov, Washington Univ. in St. Louis (United States); Kevin Kauffman, Univ. of Michigan (United States); Tyler Davis, Univ. of Illinois (United States)
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Coffee Break 3:15 PM - 3:45 PM
Session 4:
Contrast Agents
Saturday 27 January 2018
3:45 PM - 5:25 PM
Location: Room 3006 (West Level 3)
Session Chairs:
Kenneth M. Tichauer, Illinois Institute of Technology (United States) ;
Joseph P. Angelo, National Institute of Standards and Technology (United States)
Nanoprobes for optical fluorescence imaging (Invited Paper)
Paper 10478-17
Time: 3:45 PM - 4:15 PM
Author(s): Hak Soo Choi, Massachusetts General Hospital (United States)
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Development of novel molecular probes for NIR-II fluorescence imaging (Invited Paper)
Paper 10478-18
Time: 4:15 PM - 4:45 PM
Author(s): Zhen Cheng, Stanford Univ. (United States)
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Improved identification of cranial nerves using paired-agent imaging: topical staining protocol optimization through experimentation and simulation
Paper 10478-19
Time: 4:45 PM - 5:05 PM
Author(s): Veronica C. Torres, Todd Wilson, Austeja Staneviciute, Illinois Institute of Technology (United States); Richard W. Byrne, Rush Univ. Medical Ctr. (United States); Kenneth M. Tichauer, Illinois Institute of Technology (United States)
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Topical application of nerve-specific fluorophores for image-guided nerve sparing surgical procedures
Paper 10478-20
Time: 5:05 PM - 5:25 PM
Author(s): Connor W. Barth, Summer L. Gibbs, Lei Wang, Oregon Health & Science Univ. (United States)
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BiOS Hot Topics
Saturday 27 January 2018
7:00 PM - 9:05 PM
Location: Room 3022 (West Level 3)
Sunday 28 January Show All Abstracts
Session 5:
Clinical Translation and Clinical Applications I
Sunday 28 January 2018
8:15 AM - 10:00 AM
Location: Room 3006 (West Level 3)
Session Chairs:
Hak Soo Choi, Massachusetts General Hospital (United States) ;
Jakob Unger, Univ. of California, Davis (United States)
Is it really molecular guided surgery (or just EPR effect)? Understanding and overcoming the effects of cancer physiology on tumor contrast (Invited Paper)
Paper 10478-21
Time: 8:15 AM - 8:45 AM
Author(s): Kenneth M. Tichauer, Illinois Institute of Technology (United States)
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Tumor-targeted fluorescent dyes for fluorescence-guided surgery (Invited Paper)
Paper 10478-22
Time: 8:45 AM - 9:15 AM
Author(s): Philip Low, Sakkarapalayam M. Mahalingam, Lindsay E. Kelderhouse, Purdue Univ. (United States); Pravin Gagare, Mohammad Noshi, Sumith Kularatne, On Target Labs., LLC (United States)
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Dual probe difference specimen imaging for rapid identification of margin assessment during breast conserving surgery
Paper 10478-23
Time: 9:15 AM - 9:30 AM
Author(s): Jasmin Schaefer, Oregon Health & Science Univ. (United States); Connor W. Barth, Oregon Health & Science Univ. (United States); Vince Rossi, Kimberley S. Samkoe, Scott C. Davis, Thayer School of Engineering at Dartmouth (United States); Summer L. Gibbs, Oregon Health & Science Univ. (United States)
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Thick tissue diffusion model with binding to optimize topical staining in fluorescence breast cancer margin imaging
Paper 10478-24
Time: 9:30 AM - 9:45 AM
Author(s): Xiaochun Xu, Illinois Institute of Technology (United States); Soyoung Kang, Yu Wang, Jonathan T. C. Liu, Univ. of Washington (United States); Kenneth M. Tichauer, Illinois Institute of Technology (United States)
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A fluorescent humanized anti-CEA antibody specifically labels metastatic pancreatic cancer in a patient-derived orthotopic xenograft (PDOX) mouse model
Paper 10478-25
Time: 9:45 AM - 10:00 AM
Author(s): Thinzar Lwin, Moores Cancer Ctr., Univ. of California, San Diego (United States); Takashi Murakami, AntiCancer, Inc. (United States); Paul J. Yazaki, City of Hope (United States); Bryan Clary, Moores Cancer Ctr., Univ. of California, San Diego (United States); Robert M. Hoffman, AntiCancer, Inc. (United States); Michael Bouvet, Moores Cancer Ctr., Univ. of California, San Diego (United States)
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Coffee Break 10:00 AM - 10:30 AM
Session 6:
Clinical Translation and Clinical Applications II
Sunday 28 January 2018
10:30 AM - 12:15 PM
Location: Room 3006 (West Level 3)
Session Chairs:
Summer L. Gibbs, Oregon Health & Science Univ. (United States) ;
Conor L. Evans, Wellman Ctr. for Photomedicine (United States)
Chemical digitization of a physiologic signal for tumor imaging to facilitate software assisted image guided surgery (Invited Paper)
Paper 10478-26
Time: 10:30 AM - 11:00 AM
Author(s): Baran Sumer, Univ. of Texas Southwestern Medical Ctr. (United States)
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Impact of fluorescence imaging in thyroid surgery (Invited Paper)
Paper 10478-27
Time: 11:00 AM - 11:30 AM
Author(s): Eren Berber, Cleveland Clinic (United States)
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Instantaneous fluorogenic spray for micro tumor detection (Invited Paper)
Paper 10478-28
Time: 11:30 AM - 11:45 AM
Author(s): Ching Tung, Weill Cornell Medicine (United States)
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Sensitivity and specificity of panitumumab-IRDye800 as an optical agent for image guided surgery in patients with head and neck cancer
Paper 10478-29
Time: 11:45 AM - 12:00 PM
Author(s): Tarn Teraphongphom, Steven Hong, Willemieke S. F. J. Tummers, Nynke S. van den Berg, Nicholas J. Oberhelman, Robert Ertsey, Guolan Lu, Adam J. Gomez, Brock A. Martin, Christina S. Kong, Eben L. Rosenthal, Stanford Univ. (United States)
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Panitumumab-IRDye800 for fluorescence-guidance based metastatic lymph node identification in patients with head and neck cancer
Paper 10478-30
Time: 12:00 PM - 12:15 PM
Author(s): Nynke S. van den Berg, Tarn Teraphongphom, Willemieke S. F. J. Tummers, Steven Hong, Guolan Lu, Adam J. Gomez , Brock A. Martin, Robert Ertsey, Nicholas J. Oberhelman, Christina S. Kong, Dimitros Colevas, Eben L. Rosenthal, Stanford Univ. (United States)
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Lunch/Exhibition Break 12:15 PM - 1:30 PM
Session 7:
Clinical Translation and Clinical Applications III
Sunday 28 January 2018
1:30 PM - 3:30 PM
Location: Room 3006 (West Level 3)
Session Chairs:
Jonathan Sorger, Intuitive Surgical, Inc. (United States) ;
Joseph P. Angelo, National Institute of Standards and Technology (United States)
The next steps in surgical imaging (Invited Paper)
Paper 10478-31
Time: 1:30 PM - 2:00 PM
Author(s): Eben L. Rosenthal, Stanford Univ. (United States)
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Molecular fluorescence guided surgery, pathology and endoscopy: new avenues for drug exploration and treatment monitoring (Invited Paper)
Paper 10478-32
Time: 2:00 PM - 2:30 PM
Author(s): Gooitzen M. van Dam, Univ. Medical Ctr. Groningen (Netherlands)
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Clinical translation of novel agents for image guided surgery (Invited Paper)
Paper 10478-33
Time: 2:30 PM - 3:00 PM
Author(s): Alexander L. Vahrmeijer, Leiden Univ. Medical Ctr. (Netherlands)
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IS-001: investigating a novel compound for fluorescent ureteral identification during robotic hysterectomy (Invited Paper)
Paper 10478-34
Time: 3:00 PM - 3:30 PM
Author(s): Richard Farnam, Texas Urogynecology & Laser Surgery Ctr. (United States)
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Coffee Break 3:30 PM - 4:00 PM
Session PD:
Panel Discussion: Guidance for Technical Performance Evaluation for Fluorescence Guided Surgery Systems
Sunday 28 January 2018
4:00 PM - 5:30 PM
Location: Room 3006 (West Level 3)

Moderators:
Brian W. Pogue, Dartmouth College (USA)
Sylvain Gioux, Univ. Strasbourg (France)

Panelists:
Timothy C. Zhu, Univ. of Pennsylvania (USA)
Vasilis Ntziachristos, Helmholtz Zentrum, Munich (Germany)
Brian C. Wilson, Univ. of Toronto (Canada)
Keith D. Paulsen, Dartmouth College (USA)
Robert Nordstrom, National Institutes of Health (USA)
T. Joshua Pfefer, US Food and Drug Administration (USA)
Bruce J. Tromberg, Univ. of California Irvine (USA)         
Yu Chen, Univ. of Maryland Baltimore (USA)
Maritoni Litorja, National Institutes of Standards & Technology (USA)
Session Sun:
Poster Session
Sunday 28 January 2018
5:30 PM - 7:00 PM
Location: Moscone West Level 2 & 3

Conference attendees are invited to attend the BiOS poster session on Sunday evening. Come view the posters, enjoy light refreshments, ask questions, and network with colleagues in your field. Authors of poster papers will be present to answer questions concerning their papers. Attendees are required to wear their conference registration badges to the poster sessions. Poster authors, view poster presentation guidelines and set-up instructions at http://spie.org/PWPosterGuidelines.
NADPH as a potential intrinsic probe for tumour margin estimation
Paper 10478-43
Time: 5:30 PM - 7:00 PM
Author(s): Hazel Stewart, Univ. of Strathclyde (United Kingdom); Ted Hupp, The Univ. of Edinburgh (United Kingdom); David J. Birch, Univ. of Strathclyde (United Kingdom)
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Fluorescent labeling of circulating tumor cells for diffuse in-vivo flow cytometry
Paper 10478-44
Time: 5:30 PM - 7:00 PM
Author(s): Roshani A. Patil, Bryan Q. Spring, Mark Niedre, Northeastern Univ. (United States)
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Integration of a wide-field spatial frequency domain and fluorescence lifetime imaging system
Paper 10478-45
Time: 5:30 PM - 7:00 PM
Author(s): Sez-Jade Chen, Xavier Intes, Rensselaer Polytechnic Institute (United States); Sylvain Gioux, Univ. de Strasbourg (France)
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A bio-inspired time domain near infrared fluorescence imager
Paper 10478-46
Time: 5:30 PM - 7:00 PM
Author(s): Nan Cui, Washington Univ. in St. Louis (United States); Steven M. Blair, Univ. of Illinois (United States); Missael Garcia, Washington Univ. in St. Louis (United States); Viktor Gruev, Univ. of Illinois (United States)
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BiOS Sunday Plenary Session
Sunday 28 January 2018
7:00 PM - 8:00 PM
Location: Room 3022 (West Level 3)

Plenary Event Details
Monday 29 January Show All Abstracts
Session 8:
Joint Session with Conferences 10476 and 10478: Isotope Optical Imaging and Cancer
Monday 29 January 2018
8:30 AM - 10:00 AM
Location: Room 3006 (West Level 3)
Session Chair:
Sylvain Gioux, Univ. de Strasbourg (France)
Optical imaging of radiotracers (Invited Paper)
Paper 10478-35
Time: 8:30 AM - 9:00 AM
Author(s): Jan Grimm, Edwin Pratt, Memorial Sloan-Kettering Cancer Ctr. (United States)
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Radioactivity in the darkroom: the role of radioluminescence microscopy in PET radiotracer characterization and development (Invited Paper)
Paper 10478-36
Time: 9:00 AM - 9:30 AM
Author(s): Guillem Pratx, Stanford Univ. (United States)
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Cerenkov luminescence imaging under ambient lighting conditions for intraoperative applications
Paper 10478-37
Time: 9:30 AM - 9:45 AM
Author(s): Justin S. Klein, Aaron R. Selfridge, Gregory S. Mitchell, Martin S. Judenhoffer, Simon R. Cherry, Univ. of California, Davis (United States)
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Flexible autoradiography for molecular imaging of tumour margins
Paper 10478-38
Time: 9:45 AM - 10:00 AM
Author(s): Kunal Vyas, Maarten Grootendorst, Lightpoint Medical, Ltd. (United Kingdom); Thomy Mertzanidou, Univ. College London (United Kingdom); Sven Macholl, Invicro, Ltd. (United Kingdom); Danail Stoyanov, Simon R. Arridge, Univ. College London (United Kingdom); David S. Tuch, Lightpoint Medical, Ltd. (United Kingdom)
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Coffee Break 10:00 AM - 10:30 AM
Session 9:
Joint Session with Conferences 10476 and 10478: Radiation Therapy Optical Imaging and Sensing
Monday 29 January 2018
10:30 AM - 11:50 AM
Location: Room 3006 (West Level 3)
Session Chair:
Brian W. Pogue, Thayer School of Engineering at Dartmouth (United States)
Single photon detection imaging of Cherenkov light emitted during radiation therapy
Paper 10478-39
Time: 10:30 AM - 10:45 AM
Author(s): Phillip M. Adamson, Jacqueline M. Andreozzi, Ethan Philip M. LaRochelle, Brian W. Pogue, Thayer School of Engineering at Dartmouth (United States)
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Progress toward noninvasive detection of tumor oxygenation utilizing Cherenkov excited luminescence scanned imaging
Paper 10478-40
Time: 10:45 AM - 11:00 AM
Author(s): Jennifer R. Shell, Dartmouth Hitchcock Medical Ctr. (United States); Ethan Philip M. LaRochelle, Petr Bruza, Brian W. Pogue, Thayer School of Engineering at Dartmouth (United States)
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Structural Cherenkov luminescence imaging with Hadamard-patterned field illumination
Paper 10478-41
Time: 11:00 AM - 11:15 AM
Author(s): Mengyu Jia, Petr Bruza, Ethan Philip M. LaRochelle, Jennifer R. Shel, Brian W. Pogue, Thayer School of Engineering at Dartmouth (United States)
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Characterization of the proton irradiation induced luminescence of materials and application in radiation oncology dosimetry
Paper 10478-42
Time: 11:15 AM - 11:30 AM
Author(s): Arash Darafsheh, Washington Univ. School of Medicine in St. Louis (United States); Rongxiao Zhang, Massachusetts General Hospital (United States); Alireza Kassaee, Jarod C. Finlay, Univ. of Pennsylvania (United States)
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Cherenkov imaging for Total Skin Electron Therapy (TSET)
Paper 10478-43
Time: 11:30 AM - 11:50 AM
Author(s): Yunhe Xie, Amit Maity, The Univ. of Pennsylvania Health System (United States); Petr Bruza, Thayer School of Engineering at Dartmouth (United States); Tianshun Miao, DoseOptics, LLC (United States); Jacqueline M. Andreozzi, Brian W. Pogue, Thayer School of Engineering at Dartmouth (United States); John Plastaras, Timothy C. Zhu, The Univ. of Pennsylvania Health System (United States)
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