The Moscone Center
San Francisco, California, United States
1 - 6 February 2020
Conference BO108
Visualizing and Quantifying Drug Distribution in Tissue IV
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Abstract Due:
24 July 2019

Author Notification:
30 September 2019

Manuscript Due Date:
8 January 2020

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Conference Chairs
Program Committee
  • Zane A. Arp, U.S. Food and Drug Administration (United States)
  • Huang-Chiao Huang, Univ. of Maryland (United States)
  • Anand T. Kumar, Massachusetts General Hospital (United States)

Program Committee continued...
  • Melissa L. Mather, Keele Univ. (United Kingdom)
  • Wei Min, Columbia Univ. (United States)
  • Alex J. Walsh, Morgridge Institute for Research (United States)
  • Cristina L. Zavaleta, The Univ. of Southern California (United States)
  • Kurt R. Zinn, The Univ. of Alabama at Birmingham (United States)

Call for
Current imaging technologies for visualization and quantification of local drug distribution in tissue, whether in vitro/ex vivo or in vivo, are extremely limited. Common among available techniques traditionally used for such imaging application in the pharmaceutical industry to elucidate the pharmacokinetics and pharmacodynamics of drugs is radio-labeling of the target molecule or active pharmaceutical ingredient (API) and mass spec imaging techniques. However, such an approach is expensive and often lead to prolonged developmental cycle. The objective of this conference is to stimulate discussions and broaden the availability of numerous advanced imaging modalities for use in the visualization and quantification of drug distribution in tissue, starting from in vitro/ex vivo assessment for preclinical development toward in vivo nonclinical and clinical development.

Technical and scientific papers related to advanced optical or combination imaging modalities that push beyond the scope of the state-of-the-art in industry are solicited. These include:

Optical and High-Energy Photon Imaging Modalities
  • Fluorescence microscopy techniques
  • Raman and coherent Raman based imaging tools
  • Infrared microscopy
  • Photoacoustic imaging
  • X-ray excited optical luminescence.

    Mass Spectroscopy and Nuclear Magnetic Resonance in Imaging
  • Matrix Assisted Laser Desorption/Ionization (MALDI)
  • Laser ablation electrospray ionization (LAESI)
  • Desorption electrospray ionization mass spectrometry (DESI-MSI)
  • Time-of-flight secondary-ion mass spectroscopy (ToF-SIMS)
  • Nuclear Magnetic Resonance (NMR).

    In vitro/ex vivo and In vivo Drug Distribution
  • Imaging in research and development for drug screening {* Preclinical development in animal models
  • Minimum therapeutic dose/minimum inhibitory concentration for preclinical dose ranging
  • Imaging in clinical development: safety and efficacy.

    Detection, Segmentation, and Extraction in Drug Quantification
  • Software algorithms for image segmentation
  • Machine learning
  • 3D reconstruction and mapping
  • Time-resolved quantification: local pharmacokinetics and pharmacodynamics
  • Correlation to pharmacologic response: clinical safety and efficacy.
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