The Moscone Center
San Francisco, California, United States
22 - 27 January 2022
Plenary Events
BiOS Hot Topics
Date: Saturday, 22 January 2022
Time: 7:00 PM - 9:00 PM PST
Location: Moscone South, Room 207/215 (Level 2 South)

7:00 PM
Welcome and Opening Remarks

Jennifer Barton
Jennifer Barton
BiOS 2022 Symposium Chair
The Univ. of Arizona (United States)
Wolfgang Drexler
Wolfgang Drexler
BiOS 2022 Symposium Chair
Medical Univ. of Vienna (Austria)

7:05 PM
Presentation of 2022 Britton Chance Biomedical Optics Award

Anita Mahadevan-Jansen
Anita Mahadevan-Jansen
SPIE President
Vanderbilt Univ. (United States)

7:10 PM
Talk by Bruce Tromberg

Bruce Tromberg
Bruce Tromberg
2022 winner of Britton Chance Biomedical Optics Award
National Institute of Biomedical Imaging and Bioengineering (United States)

7:30 PM
Moderator Remarks

Sergio Fantini
Sergio Fantini
Tufts Univ. (United States)

7:35 PM
Color revolution: super-multiplexed optical microscopy

Wei Min
Wei Min
Columbia Univ. (United States)

7:45 PM
Holographic imaging and its bioapplications

Osamu Matoba
Osamu Matoba
Kobe Univ. (Japan)

7:55 PM
Tissue optical clearing imaging: from in vitro to in vivo

Dan Zhu
Dan Zhu
Huazhong Univ. of Science and Technology (China)

8:05 PM
Live biophotonic analysis of embryonic development

Irina Larina
Irina Larina
Baylor College of Medicine (United States)

8:15 PM
Deep learning-enabled optics

Aydogan Ozcan
Aydogan Ozcan
Univ. of California, Los Angeles (United States)

8:25 PM
Cerebral health in a heartbeat

Maria Angela Franceschini
Maria Angela Franceschini
Massachusetts General Hospital, Harvard Medical School (United States)

8:35 PM
Functional photoacoustic tomography of the human brain

Lihong Wang
Lihong Wang
Caltech (United States)

8:45 PM
Closing Remarks

End of Session--opportunity to meet the speakers at the front of the plenary room.
Neurotechnologies Plenary
Date: Sunday, 23 January 2022
Time: 3:30 PM - 5:30 PM PST
Location: Moscone South, Room 207/215 (Level 2 South)
Program Track Chairs

Elizabeth Hillman, Columbia Univ. (United States)

Anna Devor, Boston Univ. (United States)

3:30 to 3:35 Welcome and Introduction, Tim Lamkins, SPIE (USA), Moderator

3:35 to 3:55 Exciting insights into neural coding with sculpted wavefronts, Shy Shoham, New York Univ. (USA)

Abstract: How are environmental stimuli encoded in neural activity and how does this activity translate into perception? Emerging photonic approaches are helping to shed light on the identity and timing of activated neurons that correlate with external sensory, as well as on which activity features are consequential for perception. In this talk, I will highlight an emerging toolbox of neurophotonics and ‘synthetic perception’ behavioral techniques that provides a new handle on this classical systems neuroscience problem. Our overall approach achieves highly precise manipulation of neural activity at different scales using two-photon holographic optogenetics or tightly focused ultrasound and new techniques for visualizing the excitation in situ, and for controlling for possible experimental confounds. Overall, this precise, synthetic approach provides a powerful new framework for testing links between sensory activity and perception.

Bio: Shy Shoham is a Professor of Ophthalmology and of Neuroscience and Physiology at NYU Langone Health and co-director of NYU Tech4Health institute. His lab develops and applies photonic, acoustic and computational tools for spatiotemporal interfacing with neural circuits. He holds a BSc in Physics from Tel-Aviv University, a PhD in Bioengineering from the University of Utah and was a Lewis-Thomas postdoctoral fellow at Princeton University. Prior to joining NYU he was a Professor of Biomedical Engineering at the Technion-IIT. He serves on the editorial boards of SPIE Neurophotonics, Journal of Neural Engineering and Translational Vision Sci. & Technology, and has co-edited the Handbook of Neurophotonics.

3:55 to 4:15 Neuroscience of the everyday world, Meryem Ayşe Yücel , Boston Univ. (USA)

Abstract: Recent advances in wearable fNIRS devices and signal processing tools expand the repertoire of unconstrained experiments for neuroscientific research. This talk will focus on our progress at the Neurophotonics Center of Boston University towards “Neuroscience in the Everyday World”.

Bio: Meryem Ayşe Yücel is a Research Assistant Professor at the Neurophotonics Center at Boston University and an active contributor to the evolving field of fNIRS research and has directed and performed numerous fNIRS human imaging studies at the Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School and now at the Neurophotonics Center at Boston University. She has also been involved in developing advanced fNIRS signal processing algorithms that focus on the removal of systemic physiology and motion artifacts as well as advancing fNIRS analysis to more robustly classify brain response at single trial level in a general linear model context. She is also a senior developer of HOMER3 and AtlasViewer.

4:15 to 4:35 Visualization of brain fiber tracts with polarized light, Tatiana Novikova, CNRS, Ecole Polytechnique (France)

Abstract: A healthy brain of human is an amazing biological processor that controls our life and consists of highly organized structures. The white matter inside brain comprises fiber tracts (bundles of axons) that connect neurons of brain cortex to other areas of brain and spinal cord. When brain tumor cells start to grow in a chaotic way, they break this highly ordered structure. Often surgery is the only option in brain tumors treatment1. The safety margin during brain tumor resection is dictated by the preservation of neurological function. Thus, intra-operative detection of exact border between tumor and healthy brain tissue is a must for complete and safe tumor excision. However, due to low contrast, it is difficult to differentiate tumor from non-infiltrated white matter during neurosurgery. Different approaches have been explored for contrast increase, but all techniques possess their drawbacks. We suggest changing the paradigm - increasing the contrast of surgical site by visualization of healthy brain by means of its fiber tracts that induce anisotropy of refractive index, whereas tumor erases this anisotropy. We have performed the proof-of-principle studies of thick sections of formalin-fixed human brain2 and fresh cadaveric animal brains under adverse conditions (blood presence, complex surface topography) with the wide-field imaging Mueller polarimeter operating in a visible wavelength range in reflection geometry and correlated them with histology images3. Our results demonstrate that this imaging modality has a potential to provide important information on the orientation of healthy brain fiber tracts at sight and delineate brain tumor during neurosurgery.

Bio: Tatiana Novikova leads the Characterization and Modeling Division of the Laboratory of Interfaces and Thin Films at Ecole polytechnique, IP Paris, France. She is also a Courtesy Professor of Biomedical Engineering Department at Florida International University, Miami, USA. Dr Novikova is OSA Fellow, the recipient of SPIE 2020 G. G. Stokes Award in optical polarization. Her research interests and area of expertise include optical polarization, Mueller polarimetry, biomedical imaging, clinical applications of polarized light, optical metrology and computational modelling of electromagnetic wave interaction with structured and random media.
Nano/Biophotonics Plenary
Date: Tuesday, 25 January 2022
Time: 10:30 AM - 11:30 AM PST
Location: Moscone South, Room 207 (Level 2 South)
Join us for the Nano/Biophotonics Plenary Session. This year's talk will be given by Hongjie Dai of Stanford Univ. (United States).


Anderson Gomes, Federal Univ. of Pernambuco (Brazil)

Plenary Speaker

Hongjie Dai, Stanford Univ. (United States)

Biological fluorescence/luminescence imaging in the 1000-1700 nm NIR-II/SWIR Window

This talk will present work on in vivo fluorescence/luminescence biological imaging in the 1000-1700 nm NIR-II/SWIR window to benefit from suppressed light scattering at these long wavelengths combined with diminished autofluorescence. I will show in vivo NIR-II imaging with millimeter tissue depth, single-cell spatial resolution, and real-time temporal resolution using a wide range of nano-scale fluorescent/luminescent nanoprobes emitting > 1000 nm including carbon nanotubes, quantum dots, rare-earth down-conversion nanoparticles, and donor-acceptor organic molecules. New imaging tools such as light sheet microscopy and confocal microscopy in NIR-II/SWIR will be presented for non-invasive molecular imaging in vivo down to mm's depths. Finally, I will show some recent results on imaging guided surgery with tumor/normal tissue signal ratios exceeding 100.

Hongjie Dai is the Jackson-Wood Professor of Chemistry at Stanford University. He has made fundamental contributions to nanosciences especially to novel carbon-based nanomaterials including carbon nanotubes and graphene nanoribbons. He pioneered nano-carbon biological and nanomedicine applications including in vivo fluorescence/luminescence imaging in the 1000-1700 nm NIR-II/SWIR window. In the renewable energy area he invented new electrocatalysts, the aluminum-ion battery and Na/Cl2 and Li/Cl2 batteries. Dai is a Member of the US National Academy of Sciences, National Academy of Medicine and Fellow of the American Academy of Arts and Sciences. Dai received the APS James McGroddy Prize for New Materials, the ACS Pure Chemistry Award, the MRS Mid-Career Researcher Award, the NIH Director’s Pioneer Award and others.
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