The Moscone Center
San Francisco, California, United States
1 - 6 February 2020
Plenary Events
BiOS Hot Topics
Date: Saturday 1 February 2020
Time: 7:00 PM - 9:30 PM
Location: Room 206/214 (Level 2 South)
7:00 PM - 7:05 PM: Welcome and Opening Remarks

BIOS 2020 Symposium Chair
Jennifer Barton, The Univ. of Arizona (United States)

BIOS 2020 Symposium Chair
Wolfgang Drexler, Medical Univ. of Vienna (Austria)

7:05 PM - 7:10 PM: Presentation of 2020 Britton Chance Biomedical Optics Award by SPIE President

7:10 PM - 7:30 PM: Presentation by Steven Jacques, Univ. of Washington (United States); 2020 Britton Chance Biomedical Optics Award Winner

7:30 PM to 7:35 PM: Hot Topics Facilitator Remarks

Sergio Fantini, Tufts Univ. (United States)

7:35 PM – 7:45 PM: Optical Coherence Tomography from Research to Clinical Practice

James Fujimoto, Massachusetts Institute of Technology (United States)

7:45 PM – 7:55 PM: Computational Microscopy

Laura Waller, Univ. of California, Berkeley (United States)

7:55 PM - 8:05 PM: Seeing Early Cancer in a New Light

Sarah Bohndiek, Univ. of Cambridge (United Kingdom)

8:05 PM - 8:15 PM: Multiscale QPI

Gabriel Popescu, Univ. of Illinois at Urbana-Champaign (United States)

8:15 PM - 8:25 PM: Photoacoustic Imaging Assistants for Minimally Invasive Surgeries and Procedures

Muyinatu A. Lediju Bell, Johns Hopkins Univ. (United States) Journal of Biomedical Optics Speaker

8:25 PM - 8:35 PM: Interface of Radiation-Optical Interactions and Nanotechnology: Future Clinical Perspectives

Ewa Goldys Univ. of New South Wales (Australia)

8:35 PM – 8:45 PM: Imaging the Proteome in Living Cells

Bo Huang, Univ. of California, San Francisco (United States)

8:45 PM – 8:55 PM: X-Induced Photodynamic Therapy

Shawn Chen, NIH/NBIB (United States)

8:55 PM – 9:05 PM: AI Cell Sorting

Keisuke Goda, Univ. of Tokyo (Japan)
Neurotechnologies Plenary Session
Date: Sunday 2 February 2020
Time: 3:30 PM - 5:30 PM
Location: Room 206/214 (Level 2 South)
Initiated in 2017, this session will highlight the breadth of exciting advances occurring in the field of neurophotonics and provide a unique forum for communication and networking for leaders and innovators in the neurophotonics community.

SPIE Brain Symposium Chairs

David Boas, Boston Univ. (United States)

Elizabeth Hillman, Columbia Univ. (United States)

Welcome and Opening Remarks, David Boas, Boston Univ. (USA), Elizabeth Hillman, Columbia Univ. (USA)


New tools for optical recording of neuronal function
Robert Prevedel, European Molecular Biology Lab. (Germany)

Volitional control of neuromodulators as a novel form of neural interface
David Kleinfeld, Univ. of California, San Diego (United States)

Wearable functional near infrared spectroscopy
Audrey Bowden, Vanderbilt Univ. (USA)

Noninvasive monitoring of intracranial pressure and neurovascular coupling
Jana Kainerstorfer, Carnegie Mellon Univ. (United States)

The role of NIBIB in neuro-technology development
Bruce Tromberg, National Institutes of Health(United States)
BiOS Sunday Plenary
Date: Sunday 2 February 2020
Time: 7:15 PM - 8:00 PM
Location: Room 206/214 (Level 2 South)
Welcome and Award Presentation

John G. Greivenkamp, Univ. of Arizona (United States), 2020 SPIE President

Presentation of 2020 SPIE Biophotonics Technology Innovator Award

The SPIE Biophotonics Technology Innovator Award is presented for extraordinary achievements in biophotonics technology development that show strong promise or potential impact in Biology, Medicine, and Biomedical Optics. The award targets achievements that span disciplines and may include elements of basic research, technology development, and clinical translation.

The 2020 recipient is Nirmala Ramanujam, Duke University, Durham, North Carolina, United States, in recognition of her development of disruptive low-cost, high-performance technologies to enable see and treat paradigms for cervical cancer prevention

Talk by 2014 Nobel Prize Winner in Physics: Spying on the Secret Lives of Cells

Eric Betzig, Univ. of California, Berkeley and Howard Hughes Medical Institute (United States)
OPTO Plenary Session
Date: Monday 3 February 2020
Time: 8:00 AM - 10:05 AM
Location: Room 207/215 (Level 2 South)
8:00 AM - 8:05 AM: Welcome and Opening Remarks
Sailing He, KTH Royal Institute of Technology (Sweden) and Zhejiang Univ. (China); Yasuhiro Koike Keio Univ. (Japan)

8:05 AM - 8:45 AM: The Future of Optical Components and Materials in the Fibre

David Payne, Optoelectronics Research Ctr., The Univ. of Southampton (United Kingdom)

Professor Sir David Neil Payne CBE FRS FREng is Director of the Optoelectronics Research Centre at the University of Southampton UK. His work has had a great impact on telecommunications and laser technology over the last forty years. The vast transmission capacity of today’s internet results directly from the erbium-doped fibre amplifier (EDFA) invented by David and his team in the 1980s. His pioneering work in fibre fabrication in the 70s resulted in almost all of the special fibres in use today including fibre lasers. With US funding, he led the team that broke the kilowatt barrier for fibre laser output to international acclaim and now holds many other fibre laser performance records. He has published over 650 Conference and Journal papers. As an entrepreneur David’s activities have led to a cluster of 11 photonics spin-out companies in and around Southampton. He founded SPI Lasers PLC, which was acquired by the Trumpf Corporation of Germany. He is an Emeritus Chairman of the Marconi Society and a foreign member of the Russian Academy of Sciences, the Indian National Science Academy and the Indian Academy of Engineering. David is a fellow of the Royal Society and the Royal Academy of Engineering.

8:45 AM - 9:25 AM: Efficient Light Emission from Hexagonal SiGe

Erik Bakkers, Eindhoven Univ. of Technology (Netherlands)

Silicon and germanium cannot emit light efficiently due to their indirect bandgap, hampering the development of Si-based photonics. However, alloys of SiGe in the hexagonal phase are predicted to have a direct band gap. In this work, we demonstrate the realization of this new material and the direct band gap properties. We show efficient light emission up to room temperature accompanied by a short radiative lifetime, the hallmarks of a direct band gap material. The band gap energy is tunable in the range of 0.35 till 0.7eV opening a plethora of new applications. We finally discuss possible routes to integrate this material in Si- technology.

Erik Bakkers, after obtaining his PhD in nanoelectrochemistry at the University of Utrecht, started working at Philips Research in Eindhoven in 2000. He started his own research group, and the team focused on nanowires - lines of material with a width of several tens of nanometers- an area he continues to research, looking at integration into semiconductors in particular. In 2010, his growing interest in fundamental research resulted in Erik joining the Technical University of Eindhoven as well as Delft Technical University as part-time professor in the Quantum Transport group. His current interest is in Quantum Materials, to detect and manipulate Majorana states, and in Hexagonal Silicon, to demonstrate and exploit the predicted direct band gap in this material. He has received the Technical Review award from MIT, VICI grant, ERC CoG, ERC, AdG, and the Science AAAS Newcomb Cleveland Prize.

9:25 AM - 10:05 AM: Product Design for the Next Wave of Computing

Trond Wuellner, Google (United States)

As Moore’s Law shows signs of strain and mobile growth begins to slow globally, what comes next? How do emerging technologies challenge our long-held assumptions about computing and the products we build? Do the challenges of a threatened environment require new thinking about consumption and sustainability? In this talk, I’ll lay out a vision for the future of computing and what it means for how we build products, user experiences, and the technologies and innovations that power our growth.

Trond Wuellner received his Masters in Business Administration from the Massachusetts Institute of Technology Sloan School of Management in 2007. He's worked as a Product Manager in the High Tech industry for more than 15 years with a focus on leading high performance teams on innovative products and technologies. At Google, Trond has played key roles in the development of Chrome OS, Google WiFi, Google Pixelbook and presently serves as a Director of Product within the company's Devices and Services group. He's been awarded more than 15 patents, won prestigious design awards from iF, Red Dot and Spark and is an active mentor and advisor in the startup community.
LASE Plenary Session
Date: Monday 3 February 2020
Time: 3:30 PM - 5:40 PM
Location: Room 207/215 (Level 2 South)
3:30 PM - 3:35 PM: Welcome and Opening Remarks
Beat Neuenschwander, Berner Fachhochschule Technik und Informatik (Switzerland) and Xianfan Xu, Purdue Univ. (United States)

3:35 PM - 3:40 PM: Announcement of the 3D Printing, Fabrication, and Manufacturing Best Paper Award
Henry Helvajian, The Aerospace Corp. (United States)

3:40 PM - 4:20 PM: VCSEL: Born Small and Grown Big

Kenichi Iga, Tokyo Institute of Technology (Japan)

The surface emitting laser (VCSEL) is brightening in everybody's mobile device, every car, and every home. Industrially, we are in a period of rapid growth. Attention is drawn to the trend as a light source supporting the physical layer of AI and IoT technology. This is a talk from the invention of the surface emitting laser by the author to research, peening development, and recent strides toward expansion of applications. New technical and business areas have been now generated in the area of such as high-speed LANs, parallel optical interconnects, computer mice, laser printers, face recognition systems, LiDARs, and various optical sensors. The total sales are reaching over 2000 M$ headed by data-coms, recognition sensors, and power applications.

Kenichi Iga received Dr. Eng. from Tokyo Institute of Technology in 1968. He worked as the Professor and retired in 2001 and served as the 26th President (2007-2012). He first proposed a surface emitting laser (VCSEL) and received IEEE/LEOS William Streifer Award, IEEE/OSA John Tyndall Award, IEEE Daniel E. Noble Award, and Franklin Medal with the Bower Award.

4:20 PM - 5:00 PM: Compact Terahertz Driven Electron and X-ray Sources

Franz X. Kärtner, Deutsches Elektronen Synchrotron (Germany) and Univ. Hamburg (Germany)

Approaches towards a linear terahertz accelerator technology for compact electron and X-ray sources are discussed. The use of very high frequencies enables operation of accelerators at higher field strength with lower energetic driver pulses. First experimental results on laser based high energy terahertz generation, terahertz guns and accelerators are demonstrated. The high acceleration fields and gradients possible in terahertz devices enable novel electron bunch manipulations, bunch diagnostic and promise ultimately fully coherent X-ray production from compact sources. Latest experimental results in the implementation of electron and X-ray sources based on this technology will be discussed.

Franz X. Kärtner heads the Ultrafast Optics and X-rays Group at the Center for Free-Electron Laser Science at DESY and is Professor of Physics at Universität Hamburg. His research interests include ultrashort pulse generation and its use in strong-field physics, precision timing, as well as novel x-THz based electron and X-ray sources. He is a fellow of OSA and IEEE.

5:00 PM - 5:40 PM: Accelerators on a Chip: A Path to Attosecond Science

Robert L. Byer, Stanford Univ. (United States)

The Accelerator on a Chip International Program (ACHIP) funded by the Moore Foundation is an accelerator science program with the goal of demonstrating a laser driven accelerator on a chip. To date the international collaboration has demonstrated greater than 850MeV/meter acceleration gradient in a fused silica grating structure and has demonstrated the first accelerators based on silicon. Recent progress includes focusing and bunching of electrons to sub-femtosecond duration and demonstration an integrated silicon photonics accelerator based on inverse design principles.

A prototype accelerator that fits into a shoe box has been demonstrated. The next steps include using that accelerator for scientific studies. The ACHIP international collaboration involves more than one dozen faculty members, 25 graduate students, and a dozen staff members from Europe, the USA and Asia.

Robert L. Byer has conducted research and taught classes in lasers and nonlinear optics at Stanford University since 1969. He has made extraordinary contributions to laser science and technology including the demonstration of the first tunable visible parametric oscillator, the development of the Q-switched unstable resonator Nd:YAG laser, remote sensing using tunable infrared sources and precision spectroscopy using Coherent Anti Stokes Raman Scattering (CARS). Current research includes precision laser measurements in support of the detection of gravitational waves and laser “Accelerator on a chip”.
Nano/Biophotonics Plenary Session
Date: Tuesday 4 February 2020
Time: 10:30 AM - 11:30 AM
Location: Room 207 (Level 2 South)
Welcome and Introduction

Plasmonics Nanoparticles for Use in Theranostics

Michel Meunier, Polytechnique Montréal (Canada)

Plasmonic nanoparticles such as gold, silver or their alloys are interesting nanomaterials for their applications in therapeutics and diagnostics in nanomedicine. In this presentation, I will present recent developments performed in this field at Polytechnique. A new method for delivering exogenous biomolecules into targeted cells using an ultrafast laser and plasmonic nanoparticles will be presented. The technique of plasmon-mediated laser nanosurgery has been used to effectively perform gene transfection in various living cells and delivery of biomolecules in vivo in animal model for ophthalmic applications. This technology has been also used for locally stimulating neurons to control neuronal activity and cell signaling. Moreover, alloy nanoparticles have been synthesized using an improved seeded-growth approach. These spectrally distinctive plasmonic nanoparticles are used as biomarkers to perform quantitative multiplexed 3D imaging of cells and tissues. Our techniques show promises of innovative tools for basic research in biology and medicine as well as effective alternative technologies that could be adapted to the therapeutic, diagnostic, theranostics tools of the clinic.

Michel Meunier obtained a PhD from MIT in 1984. In 1985, he began his career at Polytechnique Montreal and he was promoted to full professor in 1993. Holder of a Canada Research Chair Tier 1 and co-founder of LTRIM Technologies, Michel Meunier is also a laureate, in 2006, of a Synergy Award for Innovation. He is a Fellow of the Canadian Academy of Engineering, as well as OSA and SPIE. In 2016, he won the Guy Rocher Award for his excellence in teaching at the university level. His intense research activities focus on the development of new optical nanomaterials, nano-optical devices and laser technology for nanomedicine applications. He has published more than 380 articles and supervised more than 120 graduate students and postdoctoral fellows. Since June 1st 2019, he is the Head of the Engineering Physics department.
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