Through non-invasive interaction between light and matter, optical imaging has become one of the most favorable and critical research tools for scientific community where a variety of topics ranging from fundamental biomedical/material science to advanced imaging applications are developed. Recent advances on more diverse imaging contrast mechanisms as well as higher spatio-temporal resolution has made advanced optical imaging technologies and their applications one of the most attractive scientific fields. This conference will provide a remarkable opportunity for scientists to present their recent progresses on exploring novel optical imaging techniques and their applications. The solicited exemplary topics include, but are not limited to: ;
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Conference 11896

Advanced Optical Imaging Technologies IV

In person: 10 - 11 October 2021
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  • Opening Ceremony and Plenary Session I
  • 1: Deep-Learning-Enhanced Imaging Technologies
  • Plenary Session II
  • 2: Computational Imaging
  • 3: Super-Resolution Imaging I
  • 4: Super-Resolution Imaging II
  • Poster Session
  • 5: Novel Imaging Technologies
Opening Ceremony and Plenary Session I
In person / Livestream: 10 October 2021 • 09:00 - 12:00 China Standard Time
9:00: Opening Ceremony
9:20: Awards and Recognition

11900-501
Author(s): Rebecca R. Richards-Kortum, Director, Rice 360 Institute for Global Health Technologies (United States), Rice Univ. (United States)
In person / Livestream: 10 October 2021 • 09:30 - 10:10 China Standard Time
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This talk will examine the challenges of designing and translating new low-cost optical technologies to improve global health equity, drawing from examples to improve newborn survival in African hospitals, to improve early detection of cervical cancer for women in Texas and Latin America, and to improve point-of-care diagnosis of COVID-19. The talk will summarize lessons learned to increase the diversity of innovation teams, and to increase the impact and sustainability of the resulting innovations.
Tea/Coffee Break 10:10 - 10:40
11890-502
Author(s): Wentao Wang, State Key Lab. of High Field Laser Physics (China), CAS Ctr. for Excellence in Ultra-intense Laser Science (China), Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences (China)
In person: 10 October 2021 • 10:40 - 11:20 China Standard Time
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X-ray free-electron lasers can generate intense and coherent radiation at wavelengths down to the sub-ångström region and have become indispensable tools for applications in structural biology and chemistry, among other disciplines. Several X-ray free-electron laser facilities are in operation; however, their requirement for large, high-cost, state-of-the-art radio-frequency accelerators has led to great interest in the development of compact and economical accelerators. Laser-wakefield accelerators can sustain accelerating gradients more than three orders of magnitude higher than those of radio-frequency accelerators, and are regarded as an attractive option for driving compact X-ray free-electron lasers. However, the realization of such devices remains a challenge owing to the relatively poor quality of electron beams that are based on a laser-wakefield accelerator. After ten years of efforts, we present an experimental demonstration of undulator radiation amplification in the exponential-gain regime by using electron beams based on a laser-wakefield accelerator.
11893-503
Author(s): Rui Zhu, Peking Univ. (China)
In person: 10 October 2021 • 11:20 - 12:00 China Standard Time
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Perovskite solar cells have attracted tremendous attention in recent years due to the high device performance and the superior optoelectronic properties of perovskite materials. In this talk, I will give an introduction about the advances of perovskite solar cells. Then, I will present our efforts on improving the device performance and understanding the device physics of perovskite solar cells. In addition, I will also discuss the advantages of perovskite solar cells for space aircraft application. We have some preliminary efforts of sending the perovskite solar cells into near space. I will share our view about the exciting possibilities for perovskite solar cell technology.
Break
Lunch Break 12:00 - 13:30
Session 1: Deep-Learning-Enhanced Imaging Technologies
In person: 10 October 2021 • 13:30 - 15:00 China Standard Time
Session Chair: Kebin Shi, Peking Univ. (China)
11896-1
Author(s): Minbiao Ji, Fudan Univ. (China)
In person: 10 October 2021 • 13:30 - 14:00 China Standard Time
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Picosecond stimulated Raman scattering (ps-SRS) microscopy has benefited from high spectral resolution for label-free imaging with molecular specificity, and hence showed broad applications in biomedical imaging, such as rapid and intraoperative histology. In contrast, femtosecond SRS (fs-SRS) is superior in improved sensitivity, but lacks spectral resolution and molecular specificity. Here we applied U-Net deep neural network to extract multi-channel SRS images from a single femtosecond SRS image. The method was further applied in the rapid and intelligent diagnosis on fresh gastric endoscopic biopsies.
11896-2
Author(s): Peng Fei, Fang Zhao, Yuxuan Zhao, Lanxin Zhu, Huazhong Univ. of Science and Technology (China)
In person: 10 October 2021 • 14:00 - 14:30 China Standard Time
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We have developed novel deep-learning-enhanced 3D fluorescence microscopes that can either reconstruct a 3D volume based a single 2D capture (2D-to-3D) or increase the spatial resolution based on a single 3D input (3D-to-better 3D). These computational fluorescence microscopy techniques has provided imaging throughput 2 to 3 order of magnitudes higher than conventional 3D fluorescence microscopes, such as standard confocal microscope and light-sheet fluorescence microscope. Using these techniques, we can image neuronal activities across moving Caenorhabditis elegans and blood flow in a beating zebrafish heart at single-cell resolution with volumetric imaging rates up to 200 Hz. We can map the millions of neurons across a whole macro-scale mouse brain at subcellular resolution within five minutes. We can also three-dimensionally reveal the organelles interactions at video rate and isotropic 100-nm superresolution.
11896-3
Author(s): Delong Zhang, Zhejiang Univ. (China)
In person: 10 October 2021 • 14:30 - 15:00 China Standard Time
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Optical phase imaging has found wide applications from transparent cells to nanostructures. The phase information contained in the wavefront of the probe beam, detected by wavefront sensing techniques, relies on interference or microlens arrays, which adds complications and aberrations. In contrast, direct imaging of the distorted wavefront results in complicated phase retrieval with low contrast. We developed a new nonlinear optical encoding approach based on the phase-sensitive second harmonic signals that are generated after the sample. A deep neural network is developed for efficient recovery of the original phase images, termed as second harmonic imaging enhanced by deep learning decipher (SHIELD). SHIELD keeps the advantages of the second harmonic imaging and demonstrates label-free phase imaging with single-shot capability with a sensitivity of 1/100 wavelength and high robustness against noises, enabling applications from biological imaging to wavefront sensing.
Break
Tea/Coffee Break 15:00 - 15:30
Plenary Session II
In person / Livestream: 10 October 2021 • 15:30 - 16:20 China Standard Time
15:30: Welcome and Introduction

Q&A period will follow after the talk
11905-504
Author(s): Peter L. Knight, Blackett Lab., Imperial College London (United Kingdom), UK National Quantum Technology Strategic Advisory Board for UKRI (United Kingdom)
In person / Livestream: 10 October 2021 • 15:35 - 16:05 China Standard Time
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The UK through a mix of government and industry funding has committed more than £1Bn over 10 years to a coordinated programme in quantum technology. Seven years into this programme I will describe here how we got there, and our goals for the future. The UK National Quantum Technology Programme has induced a step change in the UK’s capabilities for pushing forward a new sector in future information technologies. I describe how the programme arose and the activities it supported and influenced to deliver these new capabilities, building on a first phase almost £480M investment across several UK government agencies. The UK programme is now in its second phase, with a further substantial investment by UK government and global industries in the UK making a total of over £1Bn. I will describe our plans for ensuring the advanced quantum science and demonstrator platforms in imaging, sensing, communications and computing developed over the past seven years will drive the formation of the QT sector and embed quantum tech in a broad range of industries. References 1. “Blackett Review: The Quantum Age: technological opportunities.” Government Office for Science, Available: https://www.gov.uk/government/publications/quantum-technologies-blackett-review; https://uknqt.ukri.org/files/strategicintent2020/; Peter Knight and Ian Walmsley 2019 Quantum Sci. Technol. 4 040502
Break
Tea/Coffee Break 16:20 - 16:30
Session 2: Computational Imaging
In person: 10 October 2021 • 16:30 - 17:40 China Standard Time
Session Chair: Minbiao Ji, Fudan Univ. (China)
11896-4
Author(s): Chao Zuo, Nanjing Univ. of Science and Technology (China)
In person: 10 October 2021 • 16:30 - 17:00 China Standard Time
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When it comes to ``phase measurement" or ``quantitative phase imaging", many people will automatically connect them with ``laser" and ``interferometry". Indeed, conventional quantitative phase imaging and phase measurement techniques generally rely on the superposition of two beams with a high degree of coherence: complex interferometric configurations, stringent requirements on the environmental stabilities, and associated laser speckle noise severely limit their applications in optical imaging and microscopy. On a different note, as one of the most well-known phase retrieval approaches, the transport of intensity equation (TIE) provides a new non-interferometric way to access quantitative phase information through intensity only measurement. Despite the insufficiency for interferometry, TIE is applicable under partially coherent illuminations (like the Kohler's illumination in a conventional microscope), permitting optimum spatial resolution, higher signal-to-noise ratio, and better
11896-5
Author(s): Kaiqin Chu, Siyue Guo, Zachary J. Smith, Univ. of Science and Technology of China (China)
In person: 10 October 2021 • 17:00 - 17:20 China Standard Time
11896-6
Author(s): Jiaji Li, Ning Zhou, Zhidong Bai, Shun Zhou, Qian Chen, Chao Zuo, Nanjing Univ. of Science and Technology (China)
In person: 10 October 2021 • 17:20 - 17:40 China Standard Time
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We propose the optimizing design of illumination pattern in partially coherent optical diffraction tomography (PC-ODT), and the custom-build quantitative criterion is demonstrated to maximize the performance of POTF related to the “goodness” evaluation of an illumination aperture. Source modulation with different segment scale and gray scale is implemented to acquire arbitrary distribution source, and the corresponding threedimensional (3D) phase optical transfer function (POTF) can be easy obtained through the numerical incoherent superstition of each segment components. Further, the simulation and experimental results is presented support this finding as well, and the proposed method is expected to find versatile applications in biological and biomedical research.
11896-7
Author(s): Ryoichi Horisaki, The Univ. of Tokyo (Japan)
On demand
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Computational imaging is a powerful imaging framework by cooperating optics and information science. In this talk, I will present our research activities related to computational imaging with scattering media and machine learning.
Session 3: Super-Resolution Imaging I
In person: 11 October 2021 • 08:30 - 10:10 China Standard Time
Session Chair: Shian Zhang, East China Normal Univ. (China)
11896-8
Author(s): Wei Ji, Lusheng Gu, Tao Xu, Institute of Biophysics (China)
In person: 11 October 2021 • 08:30 - 09:00 China Standard Time
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Remarkable progress in Single molecule localization microscopy (SMLM) has been made in the past decade. Here we developed interferometric and cryogenic imaging which exhibit excellent localization precision performances compared to conventional SMLMs. We introduced interferometric SMLMs named ROSE and ROSE-Z. A fluorescence molecule is located by the intensities of multiple excitation patterns of an interference fringe, providing improvement in the localization precision compared to the conventional centroid fitting method at the same photon budget. We demonstrate this technique by resolving a nanostructure down to 5 nm. We also built an ultra-stable super-resolution cryo-FM that exhibits excellent thermal and mechanically stability. We have demonstrated the super-resolution imaging capability of this system. The results suggest that our system is particularly suitable for SMLM and cryogenic super-resolution correlative light and electron microscopy.
11896-9
Author(s): Xiang Hao, Zhejiang Univ. (China)
In person: 11 October 2021 • 09:00 - 09:30 China Standard Time
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Understanding cellular organization demands the best possible spatial resolution in all three dimensions (3D). In fluorescence microscopy, this is achieved by 4Pi nanoscopy methods that combine the concepts of using two opposing objectives for optimal diffraction-limited 3D resolution with switching fluorescent molecules between bright and dark states to break the diffraction limit. However, optical aberrations have limited these nanoscopes to thin samples and prevented their application in thick specimens. Here we have developed an improved isoSTED nanoscope, which utilizes an advanced adaptive optics strategy to achieve sub-50 nm isotropic resolution of structures such as neuronal synapses and ring canals previously inaccessible in tissue. The adaptive optics scheme presented in this work is generally applicable to any microscope with a similar beam path geometry involving two opposing objectives to optimize resolution when imaging deep in aberrating specimens.
11896-10
Author(s): Zhihao Zhou, Wei Liu, Jiajing He, Lei Chen, Xin Luo, Dongyi Shen, Shanghai Jiao Tong Univ. (China); Jianjun Cao, Jiangnan Univ. (China); Yaping Dan, Xianfeng Chen, Wenjie Wan, Shanghai Jiao Tong Univ. (China)
In person: 11 October 2021 • 09:30 - 09:50 China Standard Time
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Abbe diffraction limit poses a great challenge in many systems involved with wave dynamics, such as imaging, astronomy and photolithography. Abbe theory suggests that sub-wavelength features are usually associated with evanescent waves, which only exist in wavelength scale away from the target. For conventional optics with limited NAs, insufficient far-field detection of evanescent fields precludes resolution better than lambda/2. Originally formulated in linear optics, the Abbe limit can be broken by nonlinear optical interactions. Here we extend the Abbe theory into a nonlinear regime and experimentally demonstrate a far-field, label-free, and scan-free super-resolution imaging technique. To break the diffraction limit, a nonlinear four-wave mixing technique is implemented to retrieve near-field scattered evanescent waves, achieving sub-wavelength resolution of lambda/5.6. This method paves the way for applications in biomedical imaging, semiconductor metrology, photolithography.
11896-11
Author(s): Mingwei Tang, Qianwei Zhang, Muchun Lin, Yubing Han, Qing Yang, Xu Liu, Zhejiang Univ. (China)
In person: 11 October 2021 • 09:50 - 10:10 China Standard Time
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In the linear spatial frequency shift (SFS) super-resolution imaging, when the magnitude of SFS exceeds twice the detection aperture, there will be a missing of spatial frequency. For this reason, a tunable and deep SFS imaging method based on optical chips has been developed to realize the precise multi-level control of the magnitude and direction of the illumination evanescent field's wavevector. In this presentation, we present our recent work on tunable deep-SFS SR chip to achieve a resolution beyond 3 times the Abbe diffraction limit. Two methods of tunable deep-SFS imaging based on optical chips have been developed, one using Gallium Phosphide (GaP) integrated optical waveguide chip, with which three-dimensional SR imaging of fluorescently labeled samples can be achieved; another is based on a wafer-scale universally tunable deep-SFS SR microscopy imaging chip, which is suitable for 2D imaging of both label-free and labeled samples.
Break
Tea/Coffee Break 10:10 - 10:40
Session 4: Super-Resolution Imaging II
In person: 11 October 2021 • 10:40 - 12:00 China Standard Time
Session Chair: Xiang Hao, Zhejiang Univ. (China)
11896-12
Author(s): Xin Guo, Rui Pu, Zhimin Zhu, Shuqian Qiao, Yusen Liang, Qiuqiang Zhan, South China Normal Univ. (China)
In person: 11 October 2021 • 10:40 - 11:10 China Standard Time
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Stimulated emission depletion (STED) microscopy provides diffraction-unlimited imaging resolution while preserving the merits of confocal fluorescence microscopy, but fundamentally suffers from sophisticated, deficient probe-defined laser schemes and high illumination intensities. Here we demonstrate a strategy of stimulated-emission induced excitation depletion. With the cascade amplified depletion effects, we achieve emission depletion for a wide range of emitters by manipulating their common sensitizer using a single pair of low-power, NIR CW lasers. We demonstrate almost completely depletion efficiency with a very low saturation intensity, and nanoscopic imaging with a series of nanoprobes, two-color STED imaging, as well as subcellular imaging of the immunolabelled tunnel nanotubes.
11896-13
Author(s): Chonglei Zhang, Shenzhen Univ. (China)
In person: 11 October 2021 • 11:10 - 11:40 China Standard Time
11896-14
Author(s): Ying Ma, Xidian Univ. (China)
In person: 11 October 2021 • 11:40 - 12:00 China Standard Time
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Phase imaging has recently allowed label-free imaging of certain large cellular organelles, however endoplasmic reticulum (ER) networks and the fusion and fission of mitochondria, due to their low phase contrast, still need fluorescent labeling to be adequately imaged. We report a quantitative phase microscope with ultra‐oblique illumination with enhanced contrast for small cellular objects, allowing us to see ER structure and dynamics with high contrast for the first time without labeling. The phase images have high spatiotemporal resolution (~245 nm, 250 Hz), allowing visualization of ER vibration and mitochondrial spinning. These and continuing results will be presented.
Break
Lunch Break 12:00 - 13:30
Poster Session
In person: 11 October 2021 • 13:00 - 14:30 China Standard Time
Conference attendees are invited to attend the poster session on Monday afternoon. Come view the posters, ask questions, and network with colleagues in your field. Authors of poster papers will be present to answer questions concerning their papers. Attendees are required to wear their conference registration badges to the poster session.

Poster Setup: Monday 10:00 to 13:00
View poster presentation guidelines and set-up instructions at
https://spie.org/PA/poster-presentation-instructions
11896-23
Author(s): Yan Zhang, Xiaoqiong Tang, Aisi Shi, Yuhua Wang, Zhengchao Wang, Hongqin Yang, Fujian Normal Univ. (China)
On demand | Presented Live 11 October 2021
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The development of tumor is closely related to extracellular matrix, which changes the biomechanical behavior of cells.Research have prepared polyacrylamide hydrogel substrates of differing stiffness according to the hardness values of breast tissue under normal and tumor physiological conditions. Then AFM was used to measure the mechanical properties of breast cells with different degrees of malignancy grown on different stiffness substrates. To explore the reasons for the changes in the young’s modulus of three breast cells, the distribution of cellular actin filaments were observed with a confocal microscope. These results showed that when the substrate hardened, the viscoelasticity of benign breast cells increased significantly, and the other two cancer cells also changed to some extent. We also found that the harder the substrate, the more conducive to the spreading behavior of cells, and the weaker response of malignant cells to substrates.
11896-24
Author(s): Hua Liu, Luoyang Electro-optical Equipment Research Institute (China); quanxin Ding, Ronggang Zhu, Mingsuo Li, Liwei Zhou, Science and Technology on Electro-optic Control Laboratory, China (China)
On demand | Presented Live 11 October 2021
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Based on single molecule microscopy in modern domain, a method of continuous zoom multiple configuration, with a micro lens array and core optics is attempt to establish model by novel principle on resonance energy transfer and high accuracy localization, by which the system resolution can be improved with a level of a few nanometers. A comparative study on traditional vs modern methods can demonstrate that the dialectical relationship and their balance is important, among Merit function, Optimization algorithms and Model parameterization. The effect of system evaluated criterion that MTF, REA, RMS etc. can support our arguments qualitatively. The results can develop new products
11896-25
Author(s): Sen Zhou, Long Chen, Jin Zhou, Yu Yan, Chongqing Institute of Metrology and Quality Inspection (China)
On demand | Presented Live 11 October 2021
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To overcome some of the restrictions mentioned above, edges of particles in binary image are first detected based on automatic threshold decomposition of the original gray-scale image. Then, the internal holes are filled in some individual detection region. In order to separate from different regular shapes, a selected threshold for the rectangularity filter has been applied. Finally, by use of Euclidean distance map (EDM), the size measurement of individual particle is calculated. Additionally, the specific surface area can also be calculated if needed.
11896-26
Author(s): Kaiqin Chu, Ruijie Shi, Zachary J. Smith, Univ. of Science and Technology of China (China)
In person: 11 October 2021 • 13:00 - 14:30 China Standard Time
11896-27
Author(s): Yang Pan, Kaiqin Chu, Zachary J. Smith, Univ. of Science and Technology of China (China)
In person: 11 October 2021 • 13:00 - 14:30 China Standard Time
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Spatial light interference microscopy has advantages such as label-free and speckle-free compared to holography based microscopy. However, the axial resolution is the worst among the three dimensions, resulting in low-contrast in dense regions or thicker samples. Another common foe in the phase contrast image is the halo artifacts. In our method, we employ both terms in the image formation and design the inverse filtering accordingly, a solution hitherto overlooked by the community and naturally maintains the real-valued property of the scattering potential. Further, our algorithm is non-iterative and thus can be implemented in real-time. The reconstruction of both beads and cell data demonstrate that our method achieves state-of-the-art results. Image fidelity after processing is verified through comparison with fluorescence images.
11896-28
Author(s): Hong Cheng, Xiaotian Zhu, Yong Liu, Li Wang, Yi Wu, Chuan Shen, Anhui Univ. (China)
In person: 11 October 2021 • 13:00 - 14:30 China Standard Time
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Abstract: The process of calculating the phase from the directly obtained focused and defocus intensity information is called phase retrieval and the defocus distance between the intensity images has a great influence on the accuracy of the retrieval results. An adaptive phase retrieval algorithm based on convolutional neural network is proposed in order to obtain better phase retrieval results at any defocus distance. At any defocus distance, the initial retrieval results are obtained by phase retrieval algorithm module, and then the accuracy of the results is further improved by convolutional neural network module. Experiments show that the proposed algorithm is suitable for different defocus distances and has good accuracy and stability.
11896-29
Author(s): Xiaoting Peng, Dong Liang, Shanshan Zheng, Yuyao Hu, Jun Liu, Guohai Situ, Shanghai Institute of Optics and Fine Mechanics (China)
On demand | Presented Live 11 October 2021
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Light sheet fluorescence microscopy (LSFM) utilizes a light sheet to optically section samples which is an ideal tool for long-time microscopic observation of living samples. However, due to the inherent characteristics of Gaussian light sheet, there is a contradiction between the field of view and depth resolution of LSFM. In order to maintain a large field of view, the thickness of Gaussian light sheet is limited.Here, we propose a depth resolution enhancement method for LSFM. The incorporation of light field imaging into LSFM allows the acquirement of light field information within the Gaussian light sheet. By using the light field back projection (LFBP) reconstruction algorithm and depth estimation algorithm, it is possible to obtain the depth information in a light sheet, so as to improve the depth resolution.The proposed method can achieve a depth resolution of 0.5um when the thickness of the light sheet is kept at 6um to ensure a large field of view.
11896-30
Author(s): Guang Han, Yutong Wang, Tiangong Univ. (China); Xinming Dong, Tianjin Rehabilitation Ctr. (China); Zhe Zhao, Huiquan Wang, Jinhai Wang, Tiangong Univ. (China); Ximing Li, Tianjin Chest Hospital (China)
On demand | Presented Live 11 October 2021
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The stacked autoencoder (SAE) neural network applied to diffuse optical tomography (DOT) achieves accurate and stable detection of the position and size of tissue abnormality. The quality of modeling data influences the robustness and the accuracy of the model, the measurability of the model determines the effective range of the data cleaning method used in clinical practice. In order to determine the effective range of this method in clinical use, we analyze the measurability of anomaly detection based on DOT method. The analysis result is used as a priori information to clean the neural network sample data set used in this work. The results show that excluding the data outside the measurable range, the proposed method enables the network to achieve a prediction accuracy of 99% within the measurable range and achieves rapid and accurate detection of the position and size of abnormality in the tissue.
11896-31
Author(s): Qian Shen, Jiasong Sun, Qian Chen, Chao Zuo, Nanjing Univ. of Science and Technology (China)
In person: 11 October 2021 • 13:00 - 14:30 China Standard Time
11896-32
Author(s): Shuo Peng, Qun Hao, Yao Hu, Shaohui Zhang, Beijing Institute of Technology (China)
In person: 11 October 2021 • 13:00 - 14:30 China Standard Time
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The Structured Light Field(SLF) system acquires light field information by replacing the traditional camera in the Fringe Projection Profilometry(FPP) system with a light field camera, which could simultaneously obtain the spatial and angular distribution of light. Combined with subsequent image processing, SLF can effectively improve the robustness and dynamic range of 3D measurement. Similar to the traditional FPP, the accuracy of the SLF system is largely affected by the calibration, and the optical structure of the light field camera makes the calibration process more complicated. This paper presents a hybrid calibration method of the SLF system combining the back-projection stereo-vision and phase-coordinate mapping methods.
11896-33
Author(s): Wei Guo, Nan Zeng, Jiawei Song, Hui Ma, Tsinghua Univ. Shenzhen International Graduate School (China)
On demand | Presented Live 11 October 2021
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A common polarization measurement system consists of a quarter-wave plate and a linear polarizer, and the rotation of the wave plate can provide different phase retardance. However, the rotating phase retarder will introduce some unwanted frequency components in the light intensity signal, which may affect the correct information extraction for dynamic observation of the optical process. In this work, we analyzed the effective working frequency band of the polarization measurement system and pointed out how to judge the reliability of dynamic periodic polarization signals. We present the parameter selection strategy of the cutoff frequency of the filter, sampling frequency and rotation angular velocity for a specific dynamic polarization change of scattered light. Finally, we apply our work in the polarization monitoring of tissue optical clearing and show the improvement of the measurement stability and accuracy.
11896-34
Author(s): Cong Peng, Qiurong Yan, Wencheng Li, Nanchang Univ. (China)
In person: 11 October 2021 • 13:00 - 14:30 China Standard Time
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The combination of single-pixel imaging and single-photon counting technology can realize ultra-high-sensitivity photon counting imaging. The classic least squares method is no longer suitable for solving underdetermined linear systems because of the frequent occurrence of noise amplification, ambiguity and overlap. Compressed sensing theory based on prior constraints provides a stable and high-quality reconstruction solution. This paper proposes a new type of autoencoder network prior for the reconstruction of single-photon-counting compressed images. The experimental results show that the reconstruction quality has been effectively improved, which is more advantageous than the traditional one-norm prior. In addition, we also proposed a multi-channel prior idea, which can further improve the quality of reconstruction.
11896-35
Author(s): Anqing Chen, Xianlin Song, Nanchang Univ. (China)
In person: 11 October 2021 • 13:00 - 14:30 China Standard Time
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Photoacoustic imaging (PAI) is a popular medical imaging technology at present. It is safe and non-invasive while ensuring better resolution and imaging depth. The PAI uses the photoacoustic effects of pulsed laser radiation on the surface of living organisms. The energy of the laser beam is in the form of Gaussian distribution. In order to explore the possible influence of this non-ideal light source on the modeling of PAI. In this paper, the photoacoustic effect of Gaussian finite - width pulsed beam on gastric neoplasm tissue has been modeled and simulated by finite element method. The characteristics of photoacoustic effects produced by the beam has been studied. It is helpful to perfect the defects in the PAI model of ideal point pulsed laser.
11896-36
Author(s): Aojie Zhao, Xianlin Song, Nanchang Univ. (China)
In person: 11 October 2021 • 13:00 - 14:30 China Standard Time
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We use the k-wave toolbox, to construct a compressed-sensing-based photoacoustic imaging model, and use the Jacques Hadamard Observation Matrix and the OMP algorithm to reconstruct the image. The restored image contains the main information of the original image, it means that the original image can be reconstructed by means of compression perception theory and suitable de-noising method. Compared with Nyquist's sampling method, the amount of data collected by our compressed sensing theory is greatly reduced, which saves resources and space to a great extent. This theory has a great advantage for the photoacoustic imaging of big data, and also can provide the convenience of time for the following image analysis.
11896-37
Author(s): Ganyu Chen, Xianlin Song, Nanchang Univ. (China)
In person: 11 October 2021 • 13:00 - 14:30 China Standard Time
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We build a simulation platform for Airy beam photoacoustic microscopy based on K-Wave simulation toolbox. This platform uses Airy beam to inspire initial Photoacoustic signal in large volume and K-Wave simulation toolbox to simulate the propagation, recording and reconstruction process of Photoacoustic signal, which solve the problem of traditional Photoacoustic microimaging system We measured the performances of the constructed Photoacoustic microscopy system by simulating A-Scan, B-Scan and C-Scan, such as axial resolution, transverse resolution and depth of field, and verified the three-dimensional imaging capability of the Airy beam photoacoustic microscopy simulation platform by the three-dimensional imaging of the vertically tilted fiber.
11896-38
Author(s): Zhuangzhuang Wang, Xianlin Song, Nanchang Univ. (China)
In person: 11 October 2021 • 13:00 - 14:30 China Standard Time
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We study the SRCNN algorithm which is widely used in the field of image super-resolution based on deep learning and apply it to solve the problem of low resolution of photoacoustic imaging. The results show that the super-resolution reconstructed mouse cerebrovascular image has better performance compared with the traditional interpolation method through three evaluation indicators of PSNR, SSIM and AVG. SRCNN also has a good effect on the subjective visual effect. We obtained good experimental results composed of more part details, better image quality and resolution. The experiment results prove the superiority of deep learning network in solving the problem of image super-resolution. The deep learning based super resolution method has a significant application value for the problem of low resolution of photoacoustic imaging. It is hoped that this research can provide reference and theoretical guidance for improving the image quality of photoacoustic imaging.
11896-39
Author(s): Lei Gao, Changchun Univ. of Science and Technology (China); Mingna Liu, Huan Li, Shuang Wang, Shanghai Institute of Aerospace Control Technology (China)
In person: 11 October 2021 • 13:00 - 14:30 China Standard Time
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In complex thermal environment, the optical dome will be heated by strong aerodynamic force, which leads to the decrease of target detection accuracy. The non-uniform temperature distribution of the optical dome is obtained by the fluid thermal solid coupling analysis, and the thermal noise image generated by the thermal radiation of the optical dome on the detector image plane is calculated by the finite element method. The results show that the peak signal-to-noise ratio (PSNR) of the target image decreases by 67% under 2-4ma, the thickness of the optical dome increases from 3mm to 8mm under the same flight condition, the maximum temperature of the optical dome decreases by 14.7%, the maximum irradiance on the image plane of the detector decreases by 63.8%, and the peak signal-to-noise ratio increases by 63.2%.
11896-40
Author(s): Weijian Shi, Shihao Lu, Min Han, Jiangyong Hu, Tsinghua Shenzhen International Graduate School (China); Chengwei Liao, Guilin Hansmart Instrument CO., Ltd (China); Shidong Zhu, Shenzhen Han Industrial Technologies CO., Ltd (China); Xiang Qian, Xiaohao Wang, Tsinghua Univ. Shenzhen International Graduate School (China); Xinghui Li, Tsinghua Univ Shenzhen International Graduate School (China)
On demand | Presented Live 11 October 2021
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For specular reflection surface detection, high reflectivity is a large challenge to effectively extract the depth information of surface. Phase Measuring Deflectometry (PMD) based three-dimensional shape measurement is proposed for solving this problem. In this study, PMD method based on the characteristic of high specular reflectivity is used to perform structured light imaging on the glass surface to obtain depth information on the surface of the glass panel. In this paper, we propose a new image reconstruction method suitable for imaging specular reflection surface defects. According to the characteristic of the glass panel, the proposed method has a phase pre-unwrapping process and improves the least square method of unfolding and folding the phase algorithm. The experimental results show that the proposed method is more robust for imaging and detection of high-reflective plane than the traditional least squares method.
11896-41
Author(s): Zhan Tong, Shanghai Jiao Tong Univ. (China)
In person: 11 October 2021 • 13:00 - 14:30 China Standard Time
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Phase retrieval is a quantitative phase imaging (QPI) technique to recover the crucial phase from non-interferometric intensity measurements; however, some problems arise from this method itself, like the slow iteration convergence, the stagnation around the local minima, and the sensitiveness to the noise. To overcome these challenges, phase modulations are introduced in this work is to generate effective four-dimensional (4D) spatial constraints, including the phase modulations at the object plane and distinct intensity patterns at the sensor plane. These constraints are used to help realize a broader or global search in the solution space, ultimately finding out the global optimal solution. Finally, in addition to the X-ray diffraction imaging system, this method can also be applied in visible-light microscopy by adding a 4f imaging system downstream the original image plane while phase modulations are implemented at the Fourier plane of the 4f imaging system.
11896-42
Author(s): Minqi Wang, Bowen Wang, Linfei Zhang, Nanjing Univ. of Science and Technology (China); Yuhai Li, Science and Technology on Electro-Optical Information Security Control Lab. (China)
On demand | Presented Live 11 October 2021
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The wide application of the image super-resolution algorithms significantly improves the visual quality of infrared images. In this paper, an infrared image super-resolution reconstruction method based on a closed-loop regression network is proposed. The residual channel attention block is introduced into the up-sampling module group, which effectively improves the capacity of the network and increases the number of feature maps, enhances the extraction and recovery ability of infrared image features, and is conducive to the recovery of image details. Compared with other infrared information recovery methods previously proposed, the proposed method has obvious advantages in high-resolution detail acquisition capability. Neural network through closed-loop regression, this scheme overcomes the LR image to HR image defects in nonlinear mapping function, by introducing additional constraints on the LR data to reduce the space of the possible functions.
11896-43
Author(s): Yong'an Liu, Yifan Liu, Yonglin Wei, Xianghui Yang, Ruili Zhang, Hui Zhao, Jinshou Tian, Lizhi Sheng, Baosheng Zhao, Xi'an Institute of Optics and Precision Mechanics (China)
On demand | Presented Live 11 October 2021
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Photon-counting imaging detectors based on microchannel plate (MCP) and position-sensitive anode are characterized by extremely high sensitivity. In this study, a visible light photon-counting imaging detector based on induction readout was developed for the detection of weak light intensities, such as photon counting radar and biofluorescence lifetime imaging. The design is based on a 25 mm diameter multi-alkali S20 photocathode followed by a MCP stack, and read out by a high-resistance Ge layer anode. The position-sensitive anode was located at the atmosphere side of the Ge substrate. Such a detector was advantageous in terms of reconfigurability and detachability. The imaging performance of the detector was tested by using the wedge and strip anode to decode the photon event position information. The experimental results showed a detector gain reaching about 3×106, pulse height resolution (PHR) of about 105%, and spatial resolution better than 100μm.
11896-44
Author(s): Wenjian Lu, Guangbin Ren, Jiaxing Gong, Qi Li, Hui Zhang, Jing Wang, Huazhong Univ. of Science and Technology (China)
On demand | Presented Live 11 October 2021
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We proposed a machine learning based approach to construct the complex-valued pseudo transmission matrix of a random scattering medium with a simple optical setup. With the acquired matrix, we are able to reconstruct original input image and control light propagation through random scattering medium. Our proposed method combines the physical model of the transmission matrix and machine learning methods. The obtained pseudo transmission matrix is not task-specific for light controlling and imaging through scattering media. We believe our method will be helpful for imaging through biological tissues and fiber-optic communication.
11896-45
Author(s): Bo Chen, Yusi Shan, North China Univ. of Science and Technology (China)
On demand | Presented Live 11 October 2021
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For the digital holographic distributed aperture synthesis imaging system, the influence of tilt and displacement errors on the imaging quality is analyzed, anf then a parallel correction method based on target image optimization is proposed.The tilt of photodetector will lead to displacement error of image plane, and the displacement error of photodetector will lead to piston, tilt and displacement error of image plane. Therefore, there is coupling between the two kinds of errors, which need to be corrected at the same time. For these two kinds of errors, firstly, the image correlation method is used for coarse correction. Then, Taking the sharpness function of synthetic aperture target image as the optimization index function, the random parallel gradient descent algorithm is used to iteratively correct the tilt and displacement.
11896-46
Author(s): Dingaoyu Zhao, Jun Ke, Beijing Institute of Technology (China)
On demand | Presented Live 11 October 2021
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To solve the problem of time-space compression sensing, we propose a new kind of forward model to perform spatial compression and temporal compression separately. To verify our idea, we use coding templates to modulate the video data twice and then carry out spatial compression(solved by SrResNet-plus)and temporal compression(solved by TwIST). When both time and space domain compression ratios are 4:1(total compression ratio 16:1), the mean PSNR of each frame can reach 29dB. Extensive experiments involving more combinations of time-space compression ratio are performed to demonstrate our model’s flexibility.
11896-47
Author(s): Hong Cheng, Xinyu Xiang, Qiyang Zhang, Xiaotian Zhu, Anhui Univ. (China)
On demand | Presented Live 11 October 2021
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In the dual-camera phase retrieval method, the phase is solved by positive- and negative- defocusing images obtained through a single exposure after dual cameras are installed on an inverted microscope. However, due to the installation error of the cameras, translation and rotation of images exist between the images, resulting inaccurate phase retrieval results. In this paper, we proposed a dual-camera phase retrieval method based on fast adaption image restoration and transport of intensity equation. Firstly, let the positive-defocusing image be the reference image. Then using the fast adaption image restoration algorithm to find the texture information in order to find best matching block quickly. After that, priority can be change as the sum of two parts, which can avoid the situation of 0 priority. Then, burring the boundary point of restored image in order to reduce the block effect. Finally, the transport of intensity equation can be used in phase retrieval results.
Session 5: Novel Imaging Technologies
In person: 11 October 2021 • 14:30 - 17:30 China Standard Time
Session Chair: Kebin Shi, Peking Univ. (China)
11896-15
Author(s): Yunhua Yao, Pengpeng Ding, Jiali Yao, Chengshuai Yang, Dalong Qi, Shian Zhang, East China Normal Univ. (China)
On demand | Presented Live 11 October 2021
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Compressed ultrafast photography (CUP) is the fastest receive-only single-shot imaging technique up to now. By combining compressed sensing and streak imaging, CUP is able to capture ultrafast dynamics in a single shot. As a powerful tool for researching ultrafast phenomena, it has been widely applied in lots of areas. To meet the demand for more precise dynamics information and higher dimension in some application, many improvements have been conduct in CUP. For example, we have raised total variation-block match 3D filter algorithm and augmented Lagrange-deep learning hybrid algorithm to improve the reconstructed image quality of CUP, and set up a stereo-volumetric CUP system to capture 5 dimension dynamic information in a single shot. Besides, we have also developed another single-shot ultrafast optical imaging technique, chirped spectral mapping ultrafast photography (CSMUP), which utilized the spectral-temporal mapping to exact temporal information from hyperspectral image.
11896-16
Author(s): Qing Yang, Zhong Wen, Jinggang Xu, Zhenyu Dong, Qilin Deng, Liqiang Wang, Xu Liu, Zhejiang Univ. (China)
In person: 11 October 2021 • 15:00 - 15:30 China Standard Time
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The main challenge in multimode fiber imaging is modal scrambling caused by environmental fluctuation. How to get high contrast and high stable imaging is the main question. It is also desired to integrate multifunctional sensing on the fiber. In this presentation, we propose our recent work on high stable multimode fiber imaging. Wavelength modulation and omnidirectional wavevector modulation were introduced to achieve high stable high resolution imaging. We also integrate sensing of position, temperature on the optical fiber.
11896-17
Author(s): Jianpeng Ao, Fudan Univ. (China)
In person: 11 October 2021 • 15:30 - 15:50 China Standard Time
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Photochromism induced by reversible photoisomerization yielding different spectral properties have broad applications in optical memories, switches and actuators. In particular, photoswitchable fluorescent molecules have revolutionized modern light microscopy with spatial resolution far beyond diffraction limit, such as the reversible switchable/saturable optical fluorescent transition (RESOLFT) and single-molecule localization nanoscopy. However, tranditional fluorescence-based probes lack sufficient chemical specificity. Here, we engineer alkyne tagged diarylethene to realize photo-switchable stimulated Raman scattering probes with high chemical resolution, for applications in memory and living cells.
Tea/Coffee Break 15:50 - 16:10
11896-18
Author(s): Kaiqin Chu, Qi Meng, Zachary J. Smith, Univ. of Science and Technology of China (China)
In person: 11 October 2021 • 16:10 - 16:30 China Standard Time
11896-19
Author(s): Linpeng Lu, Jiasong Sun, Jiaji Li, Yao Fan, Jialin Zhang, Qian Chen, Chao Zuo, Nanjing Univ. of Science and Technology (China)
On demand | Presented Live 11 October 2021
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Transport of intensity equation (TIE) is the deterministic quantitative phase imaging (QPI) method derived from the paraxial approximation, which limits TIE to retrieving high-resolution QPI. Though it can be overcome by the phase transfer function (PTF) method, it has an incorrect phase at low frequencies due to the weak phase approximation. For most samples with thickness and details, we propose a resolution-enhanced QPI mixed-transfer-function (MTF) method based on the spatial domain and spatial frequency, using phase space theory as a bridge. The conventional TIE can obtain accurate phases at low frequencies but suffers from attenuation and blurring at high frequencies. Consequently, MTF combines with PTF to improve the maximum resolution that can be accurately reconstructed. Simulation results and experiments show that the MTF can correctly achieve high-contrast and high-resolution QPI over the entire theoretical bandwidth.
11896-21
Author(s): Qun Hao, Chuanxun Chen, Zhikuo Li, Jie Cao, Yang Cheng, Beijing Institute of Technology (China)
On demand | Presented Live 11 October 2021
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To improve the focus tunability and reduce the difficulties in fabrication, we present a novel optofluidic varifocal lens actuated by dielectric elastomer sandwiched by two conductive liquids with different refractive indexes. The lens has a compact structure: two grid frames, two passive membranes, a dielectric elastomer actuator membrane, and two conductive liquids. Two cavities of the varifocal lens are filled with different conductive liquids. The conductive liquids are not only employed as the material of the optofluidic varifocal lens because of their high transparency but also work as the compliant electrode of the dielectric elastomer actuator membrane due to their conductibility. The results experiments show that the focal length variation of the lens is greater than 100%, the response time is approximately 75 ms. The lens is free from the compliant electrodeswhich greatly reduces the difficulties in fabrication.
11896-22
Author(s): Vinu R.V., Yanyan Huang, Ziyang Chen, Huaqiao Univ. (China); Rakesh K. Singh, Indian Institute of Technology (BHU), Varanasi (India); Jixiong Pu, Huaqiao Univ. (China)
On demand | Presented Live 11 October 2021
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We demonstrate a snap-shot ghost diffraction imaging approach with potential features of simultaneous recovery of amplitude and phase of a complex-valued object from a single-shot recording of the fields at the detectors. The technique utilizes the spatial averaging as an effective replacement of ensemble averaging in the execution of the cross-correlation of intensity fluctuations at the detector plane. Furthermore, the approach adopts the concept of holography in combination with the ghost diffraction scheme for the simultaneous recovery of phase distribution along with the amplitude of the object. The proposed method is expected to find applications in the two- and three-dimensional real-time quantitative imaging, biological microscopy, tomography, and super-resolution imaging, etc.
11896-20
Author(s): Shengfu Cheng, Tianting Zhong, Li Jin, Puxiang Lai, The Hong Kong Polytechnic Univ. (Hong Kong, China)
On demand
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A new multimode fiber micro-endoscopy that integrates fiber calibration and imaging phase is proposed. The approach utilizes the back-scattered patterns emitted by the fluorescence targets at the fiber distal end to reconstruct the reflection matrix by phase retrieval algorithm. Simulations show that selective focusing through the fiber is directly achieved using the eigenvectors decomposed from the reflection matrix. It is possible to reconstruct the full fluorescent objects based on speckle correlations. Further experiments will be conducted to explore the focusing and imaging performance. The fluorescence-based reflection matrix method has the potential for re-calibration in situ and robust imaging under moderate perturbations, promising for practical micro-endoscopic applications.
Conference Chair
Shenzhen Univ. (China)
Conference Chair
The Institute of Optics, Univ. of Rochester (United States)
Conference Chair
Peking Univ. (China)
Program Committee
Tsinghua Univ. (China)
Program Committee
Duke Univ. (United States)
Program Committee
Peking Univ. (China)
Program Committee
Zhejiang Univ. (China)
Program Committee
Utsunomiya Univ. Ctr. for Optical Research & Education (Japan)
Program Committee
National Univ. of Singapore (Singapore)
Program Committee
Zhenli Huang
Wuhan National Research Ctr. for Optoelectronics (China)
Program Committee
Institute of Biophysics, Chinese Academy of Sciences (China)
Program Committee
Univ. of Technology, Sydney (Australia)
Program Committee
Zhejiang Univ. (China)
Program Committee
Warsaw Univ. of Technology (Poland)
Program Committee
The Hong Kong Polytechnic Univ. (Hong Kong, China)
Program Committee
Seoul National Univ. (Korea, Republic of)
Program Committee
Zhejiang Univ. (China)
Program Committee
Shenzhen Univ. (China)
Program Committee
Institut für Technische Optik (Germany)
Program Committee
Boston Univ. (United States)
Program Committee
Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences (China)
Program Committee
Michael G. Somekh
Shenzhen Univ. (China)
Program Committee
Shenzhen Univ. (China)
Program Committee
Nanyang Technological Univ. (Singapore)
Program Committee
City Univ. of Hong Kong (Hong Kong, China)
Program Committee
Changfeng Wu
Southern Univ. of Science and Technology of China (China)
Program Committee
Institute of Biophysics, Chinese Academy of Sciences (China)
Program Committee
Xi'an Institute of Optics and Precision Mechanics of CAS (China)
Program Committee
East China Normal Univ. (China)
Program Committee
Nanjing Univ. of Science and Technology (China)
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