Marriott Marquis Houston
Houston, Texas, United States
15 - 20 February 2020
Conference 11320
Digital Pathology
Wednesday - Thursday 19 - 20 February 2020
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Program Committee continued...
Monday 17 February Show All Abstracts
Session Plen:
Awards and Plenary Session
Monday 17 February 2020
4:00 PM - 5:15 PM
Location: Salon F

Session Chairs: Metin N. Gurcan, Wake Forest Baptist Medical Ctr. (United States) and Georgia D. Tourassi, Oak Ridge National Lab. (United States)

4:00 PM - 4:30 PM: Award presentations
Are today's Mixed Reality experience pillars and hardware architectures well aligned with the specific needs of medical imaging and surgical guidance? (Plenary Presentation)
Paper 11313-8
Author(s): Bernard C. Kress, Microsoft Corp. (United States)
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Tuesday 18 February Show All Abstracts
Tuesday/Wednesday Poster Viewing
Tuesday 18 February 2020
12:00 PM - 9:00 PM
Location: Salon D/E

Posters will be on display Tuesday and Wednesday with extended viewing until 9:00 pm on Tuesday. The poster session with authors in attendance will be Wednesday evening from 5:30 to 7:00 pm. Award winners will be identified with ribbons during the reception. Award announcement times are listed in the conference schedule.
Session WK4:
Workshop: Simulated Tumor Board: Brain and Breast
Tuesday 18 February 2020
5:00 PM - 7:00 PM
Location: Salon B

This workshop will present two example clinical cases, one breast cancer case and one brain cancer case. A multi-disciplinary team will discuss the case, the imaging information, pathology, and treatment options. The workshop will mimic the format of a standard clinical tumor board process with time for Q&A at the end.

Moderator:
Kristy Brock, PhD, DABR, FAAPM
Professor, Department of Imaging Physics and Department of Radiation Physics, Univ. of Texas MD Anderson Cancer Center (United States)

Breast Panel Speakers:
Simona Shaitelman, Univ. of Texas MD Anderson Cancer Ctr., Radiation Oncology (United States)
Isabelle Bedrosian, Univ. of Texas MD Anderson Cancer Ctr., Surgery (United States)
Jennifer Litton, Univ. of Texas MD Anderson Cancer Ctr., Medical Oncology (United States)
Wei Yang, Univ. of Texas MD Anderson Cancer Ctr., Diagnostic Radiology (United States)
Alejandro Contreras, Univ. of Texas MD Anderson Cancer Ctr., Pathology (United States)

Brain Panel Speakers:
Caroline Chung, Univ. of Texas MD Anderson Cancer Ctr., Radiation Oncology (United States)
Jeff Weinberg, Univ. of Texas MD Anderson Cancer Ctr., Surgery (United States)
Melissa Chen, Univ. of Texas MD Anderson Cancer Ctr., Diagnostic Radiology (United States)
Jason Huse, Univ. of Texas MD Anderson Cancer Ctr., Pathology (United States)
Wednesday 19 February Show All Abstracts
Session 1:
Keynote and Computer-Aided Diagnosis, Prognosis, and Predictive Analysis
Wednesday 19 February 2020
1:20 PM - 3:00 PM
Location: Salon A
Session Chairs:
John E. Tomaszewski, Univ. at Buffalo (United States) ;
Aaron D. Ward, Western Univ. (Canada)
Petascale computational pathology for precision medicine (Keynote Presentation)
Paper 11320-1
Author(s): Nasir M. Rajpoot, The Univ. of Warwick (United Kingdom)
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Compactness measures of tumor infiltrating lymphocytes in lung adenocarcinoma are associated with overall patient survival and immune scores
Paper 11320-2
Author(s): Ruiwen Ding, Prateek Prasanna, Germán Corredor, Cheng Lu, Case Western Reserve Univ. (United States); Priya Velu, Weill Cornell Medicine (United States); Khoi Le, Patrick Leo, Case Western Reserve Univ. (United States); Vamsidhar Velcheti, New York Univ. (United States); David Rimm, Kurt Schalper, Yale Univ. (United States); Anant Madabhushi, Case Western Reserve Univ. (United States)
Show Abstract
Computationally derived image markers for predicting risk of relapse in acute myeloid leukemia patients following bone marrow transplantation
Paper 11320-3
Author(s): Sara Arabyarmohammadi, Case Western Reserve Univ. (United States); Zelin Zhang, Nanjing Univ. of Information Science & Technology (China); Patrick Leo, Andrew Janowczyk, Haojia Li, Nathaniel M. Braman, Kaustav Bera, Case Western Reserve Univ. (United States); Behtash Nezami, Howard Meyerson, Univ. Hospitals Cleveland Medical Ctr. (United States); Jun Xu, Nanjing Univ. of Information Science & Technology (China); Leland Metheny, Univ. Hospitals Cleveland Medical Ctr. (United States); Anant Madabhushi, Case Western Reserve Univ. (United States), Louis Stokes Cleveland Veterans Administration Medical Ctr. (United States)
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Session 2:
Computer-Aided Diagnosis, Prognosis, and Predictive Analysis
Wednesday 19 February 2020
3:30 PM - 5:30 PM
Location: Salon A
Prediction of tumour mutational burden of squamous cell carcinoma using histopathology images of surgical specimens
Paper 11320-4
Author(s): Salma Dammak, Western Univ. (Canada); David Palma, Matthew Cecchini, London Health Sciences Ctr. (Canada); Katherina Baranova, Western Univ. (Canada); Keith Kwan, London Health Sciences Ctr. (Canada); Aaron D. Ward, Western Univ. (Canada)
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Identifying bladder layers from H&E images using U-Net image segmentation
Paper 11320-5
Author(s): Muhammad Khalid Khan Niazi, Enes Yazgan, Wake Forest Univ. School of Medicine (United States); Cheryl Lee, The Ohio State Univ. Wexner Medical Ctr. (United States); Anil Parwani, The Ohio State Univ. Medical Ctr. (United States); Metin N. Gurcan, Wake Forest Univ. School of Medicine (United States)
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Generative modeling for label-free glomerular modeling and classification
Paper 11320-6
Author(s): Brendon Lutnick, Brandon Ginley, Univ. at Buffalo (United States); Kuang-Yu Jen, Univ. of California, Davis (United States); Wen Dong, Pinaki Sarder, Univ. at Buffalo (United States)
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Hotspot detection in pancreatic neuroendocrine images using local depth
Paper 11320-7
Author(s): Muhammad Khalid Khan Niazi, Wake Forest Univ. School of Medicine (United States); Katherine Moore, Kenneth S. Berenhaut, Wake Forest Univ. (United States); Douglas J. Hartman, Liron Pantanowitz, Univ. of Pittsburgh Medical Ctr. (United States); Metin N. Gurcan, Wake Forest Univ. School of Medicine (United States)
Show Abstract
Deep learning approaches for intraoperative pixel-based diagnosis of colon cancer metastasis in a liver from phase-contrast images of unstained specimens
Paper 11320-8
Author(s): Dario Sitnik, Ivica Kopriva, Institut Ruder Boškovic (Croatia); Gorana Aralica, Arijana Pacic, Univ. Hospital Dubrava (Croatia); Marijana Popovic Hadžija, Mirko Hadžija, Institut Ruder Boškovic (Croatia)
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Transfer learning approach for intraoperative pixel-based diagnosis of colon cancer metastasis in a liver from hematoxylin-eosin stained specimens
Paper 11320-9
Author(s): Dario Sitnik, Ivica Kopriva, Institut Ruder Boškovic (Croatia); Gorana Aralica, Arijana Pacic, Univ. Hospital Dubrava (Croatia); Marijana Popovic Hadžija, Mirko Hadžija, Institut Ruder Boškovic (Croatia)
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Session PSWed:
Wednesday Poster Session
Wednesday 19 February 2020
5:30 PM - 7:00 PM
Location: Salon D/E
Making esophageal squamous cell carcinoma survival prediction from histopathological images and CT images
Paper 11320-32
Author(s): Jinlong Wang, Sun Yat-Sen Univ. (China); Leilei Wu, Guowei Ma, Sun Yat-Sen Univ. Cancer Ctr. (China); Yao Lu, Sun Yat-Sen Univ. (China)
Show Abstract
Fully automated classification of glomerular lesions in lupus nephritis
Paper 11320-33
Author(s): Brandon Ginley, Univ. at Buffalo (United States); Kuang-Yu Jen, Univ. of California, Davis (United States); Avi Rosenberg, Giovanni Maria Rossi, Johns Hopkins Univ. (United States); Sanjay Jain, Washington Univ. School of Medicine in St. Louis (United States); Pinaki Sarder, Univ. at Buffalo (United States)
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Low-cost phase imaging microscopy via Ptychographic Modulation Engine (PME)
Paper 11320-34
Author(s): Zichao Bian, Shaowei Jiang, Guoan Zheng, Univ. of Connecticut (United States)
Show Abstract
Using a 22-layer U-Net to perform segmentation of squamous cell carcinoma on digitized head and neck histological images
Paper 11320-35
Author(s): Amol Mavuduru, The Univ. of Texas at Dallas (United States); Martin Halicek, Georgia Institute of Technology & Emory Univ. School of Medicine (United States); Maysam Shahedi, The Univ. of Texas at Dallas (United States); James V. Little, Amy Y. Chen, Emory Univ. School of Medicine (United States); Larry L. Myers, The Univ. of Texas Southwestern Medical Ctr. at Dallas (United States); Baowei Fei, The Univ. of Texas at Dallas (United States)
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Predicting MYC translocation in H&E specimens of diffuse large B-cell lymphoma through deep learning
Paper 11320-36
Author(s): Zaneta Swiderska-Chadaj, Konnie Hebeda, Michiel van den Brand, Geert Litjens, Radboud Univ. Medical Ctr. (Netherlands)
Show Abstract
Automated grade classification of oral epithelial dysplasia using morphometric analysis of histology images
Paper 11320-38
Author(s): Raja Muhammad Saad Bashir, The Univ. of Warwick (United Kingdom); Hanya Mahmood, The Univ. of Sheffield (United Kingdom); Muhammad Shaban, Shan E. Ahmed Raza, The Univ. of Warwick (United Kingdom); Muhammad Moazam Fraz, National Univ. of Sciences and Technology (Pakistan); Syed Ali Khurram, The Univ. of Sheffield (United Kingdom); Nasir Rajpoot, The Univ. of Warwick (United Kingdom)
Show Abstract
Neutrophil Extracellular Traps (NETs): an unexplored territory in renal pathobiology, a pilot computational study
Paper 11320-39
Author(s): Briana A. Santo, Univ. at Buffalo (United States); Brahm H. Segal, Roswell Park Comprehensive Cancer Ctr. (United States); John E. Tomaszewski, Imtiaz Mohammad, Amber Worral, Univ. at Buffalo (United States); Sanjay Jain, Washington Univ. School of Medicine in St. Louis (United States); Michelle Visser, Pinaki Sarder, Univ. at Buffalo (United States)
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Preliminary radiomic texture analysis of high-channel fluorescence confocal images of triple-negative breast cancer biopsies
Paper 11320-40
Author(s): Madeleine S. Durkee, The Univ. of Chicago (United States); Bradie M. Ferguson, The Univ. of Chicago (United States), Univ. of Washington (United States); Rebecca Abraham, Li Lan, Hui Li, Marcus R. Clark, Maryellen L. Giger, The Univ. of Chicago (United States)
Show Abstract
Probabilistic modelling of diabetic nephropathy progression
Paper 11320-41
Author(s): Samuel P. Border, Univ. at Buffalo (United States); Kuang-Yu Jen, Univ. of California, Davis (United States); John E. Tomaszewski, Pinaki Sarder, Univ. at Buffalo (United States)
Show Abstract
Searching histology patterns in gastric glands for predicting gastric cancer survival
Paper 11320-42
Author(s): Eduardo Romero Castro, Ricardo Alexander Moncayo Martinez, Sunny Catalina Alfonso, Angel Yobany Sanchez Merchan, Univ. Nacional de Colombia Sede Bogotá (Colombia)
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Domain-adversarial neural network for improved generalization performance of Gleason grade classification
Paper 11320-43
Author(s): Ida Arvidsson, Niels Christian Overgaard, Agnieszka Krzyzanowska, Felicia-Elena Marginean, Athanasios Simoulis, Anders Bjartell, Kalle Åström, Anders Heyden, Lund Univ. (Sweden)
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Characterization of color normalization methods in digital pathology whole-slide imaging
Paper 11320-44
Author(s): Dorsa Ziaei, Univ. of Maryland, Baltimore County (United States); Wei-Chung Cheng, U.S. Food and Drug Administration (United States); Samuel Lam, Univ. of Maryland, College Park (United States); Weizhe Li, Weijie Chen, U.S. Food and Drug Administration (United States)
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The presence and location of podocytes in glomeruli as affected by diabetes mellitus
Paper 11320-45
Author(s): Kathryn E. Maraszek, Briana Santo, John E. Tomaszewski, Pinaki Sarder, Univ. at Buffalo (United States)
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Improved instance segmentation of immune cells in human lupus nephritis biopsies with Mask R-CNN
Paper 11320-46
Author(s): Madeleine S. Durkee, Adam Sibley, Junting Ai, Rebecca Abraham, Vladimir M. Liarski, Marcus R. Clark, Maryellen L. Giger, The Univ. of Chicago (United States)
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PColorNet: investigating the impact of different color spaces for pathological image classification
Paper 11320-47
Author(s): Shamima Nasrin, Zahangir Z. Alom, Tarek M. Taha, Vijayan K. Asari, Univ. of Dayton (United States)
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Deep learning convolutional networks for image quality assessment in ultra-widefield fluorescein angiography
Paper 11320-48
Author(s): Jon Whitney, eResearchTechnology Inc. (United States)
Show Abstract
Color-multiplexed single-shot dynamic focus tracking based on LED-array illumination for whole slide imaging
Paper 11320-28
Author(s): Shaowei Jiang, Zichao Bian, Guoan Zheng, Univ. of Connecticut (United States)
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Thursday 20 February Show All Abstracts
Session 3:
Segmentation of Cellular and Tissue Structures
Thursday 20 February 2020
8:00 AM - 9:40 AM
Location: Salon A
Multi-class semantic cell segmentation and classification of aplasia in bone marrow histology images
Paper 11320-10
Author(s): Leander van Eekelen, Hans Pickaers, Konnie M. Hebeda, Geert Litjens, Radboud Univ. Medical Ctr. (Netherlands)
Show Abstract
Cells detection and segmentation in ER-IHC stained breast histopathology images
Paper 11320-11
Author(s): Mohammad Faizal Ahmad Fauzi, Mohammad Fareed Jamaluddin, Fazly Salleh Abas, Multimedia Univ. (Malaysia); Jenny T. H. Lee, See Y. Khor, Kean H. Teoh, Lai M. Looi, Univ. of Malaya Medical Ctr. (Malaysia)
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A deep learning approach to assess the predominant tumor growth pattern in whole-slide images of lung adenocarcinoma
Paper 11320-12
Author(s): Francesco Ciompi, Radboud Univ. Medical Ctr. (Netherlands); Zaneta Swiderska-Chadaj, Radboud Univ. Medical Ctr. (Netherlands), Warsaw Univ. of Technology (Poland); Karolina Nurzynska, Silesian Univ. of Technology (Poland); Bartlomiej Grala, Military Institute of Medicine (Poland); Katrien Grünberg, Lieke van der Woude, Monika Looijen-Salamon, Radboud Univ. Medical Ctr. (Netherlands); Ann E. Walts, Cedars-Sinai Medical Ctr. (United States); Tomasz Markiewicz, Warsaw Univ. of Technology (Poland), Military Institute of Medicine (Poland); Arkadiusz Gertych, Cedars-Sinai Medical Ctr. (United States)
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Segmentation of mycobacterium tuberculosis bacilli clusters from acid-fast stained lung biopsies: a deep learning approach
Paper 11320-13
Author(s): Thomas E. Tavolara, Khalid M. K. Niazi, Wake Forest Univ. School of Medicine (United States); Gillian Beamer, Tufts Univ. (United States); Metin N. Gurcan, Wake Forest Univ. School of Medicine (United States)
Show Abstract
Generative modeling for renal microanatomy
Paper 11320-14
Author(s): Leema K. Murali, Brandon Ginley, Brendon Lutnick, John E. Tomaszewski, Pinaki Sarder, Univ. at Buffalo (United States)
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Session 4:
Grading and Classification of Pathology Images
Thursday 20 February 2020
10:10 AM - 12:10 PM
Location: Salon A
Three dimensional histomorphometric features from light-sheet microscopy results in improved discrimination of benign from malignant glands in prostate cancer
Paper 11320-15
Author(s): Can F. Koyuncu, Andrew Janowczyk, Cheng Lu, Patrick Leo, Case Western Reserve Univ. (United States); Adam K. Glaser, Nicholas P. Reder, Jonathan T. C. Liu, Univ. of Washington (United States); Anant Madabhushi, Case Western Reserve Univ. (United States)
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Automatic cancer sub-grading on digital histopathology images of radical prostatectomy specimens
Paper 11320-16
Author(s): Wenchao Han, Western Univ. (Canada); Michelle Downes, Theodorus Van Der Kwast, Univ. of Toronto (Canada); Joseph Chin, Stephen Pautler, Aaron Ward, Western Univ. (Canada)
Show Abstract
Texture features distinguish benign cell clusters from adenocarcinomas on bile duct brushing cytology images
Paper 11320-17
Author(s): Shayan Monabbati, Patrick Leo, Kaustav Bera, Case Western Reserve Univ. (United States); Claire W. Michael, Univ. Hospitals Cleveland Medical Ctr. (United States), Case Western Reserve Univ. (United States); Behtash Nezami, Aparna Harbhajanka, Anant Madabhushi, Case Western Reserve Univ. (United States)
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Semi-supervised breast cancer histology classification using deep multiple instance learning and contrast predictive coding
Paper 11320-18
Author(s): Ming Y. Lu, Richard J. Chen, Faisal Mahmood, Harvard Medical School (United States)
Show Abstract
Graph convolutional networks for region of interest classification in breast histopathology
Paper 11320-19
Author(s): Bulut Aygüneş, Selim Aksoy, Bilkent Univ. (Turkey); Gökberk Cinbiş, Middle East Technical Univ. (Turkey); Kemal Kösemehmetoglu, Sevgen Önder, Ayşegül Üner, Hacettepe Univ. (Turkey)
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A systematic comparison of deep learning strategies for weakly supervised Gleason grading
Paper 11320-20
Author(s): Sebastian Otálora, Oscar Jimenez-del-Toro, Manfredo Atzori, HES-SO Valais-Wallis (Switzerland); Amjad Khan, Univ. Bern (Switzerland); Vincent Andrearczyk, Henning Müller, HES-SO Valais-Wallis (Switzerland)
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Lunch Break 12:10 PM - 1:20 PM
Session 5:
Integration of Multimodal and Spatial Information
Thursday 20 February 2020
1:20 PM - 3:00 PM
Location: Salon A
Discovering correspondences between molecular profiles and morphological features via deep learning
Paper 11320-21
Author(s): Richard Chen, Faisal Mahmood, Harvard Medical School (United States), Brigham and Women's Hospital (United States)
Show Abstract
Multimodal fusion of histology and molecular features for improved survival outcome prediction
Paper 11320-22
Author(s): Richard J. Chen, Harvard Medical School (United States), Brigham and Women's Hospital (United States); Max Lu, Brigham and Women's Hospital (United States); Faisal Mahmood, Harvard Medical School (United States), Brigham and Women's Hospital (United States)
Show Abstract
Histographs: graphs in histopathology
Paper 11320-23
Author(s): Deepak Anand, Shrey Gadiya, Indian Institute of Technology Bombay (India); Amit Sethi, Indian Institute of Technology Bombay (India), Univ. of Illinois at Chicago (United States)
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Deep learning-based automated hot-spot detection and tumor grading in human gastrointestinal neuroendocrine tumor
Paper 11320-24
Author(s): Darshana Govind, Univ. at Buffalo (United States); Kuang-Yu Jen, Univ. of California, Davis (United States); Pinaki Sarder, Univ. at Buffalo (United States)
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Computer extracted features related to the spatial arrangement of tumor-infiltrating lymphocytes predict overall survival in epithelial ovarian cancer
Paper 11320-25
Author(s): Sepideh Azarianpour, German Corredor, Kaustav Bera, Patrick Leo, Nathaniel Braman, Pingfu Fu, Case Western Reserve Univ. (United States); Haider Mahdi, Cleveland Clinic (United States); Anant Madabhushi, Case Western Reserve Univ. (United States)
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Session 6:
Multispectral Imaging, Computational Microscopy and Staining
Thursday 20 February 2020
3:30 PM - 5:30 PM
Location: Salon A
Generalizing convolution neural networks on stain color heterogeneous data for computational pathology
Paper 11320-26
Author(s): Amjad Khan, Univ. Bern (Switzerland); Manfredo Atzori, Sebastian Otálora, Vincent Andrearczyk, Henning Müller, HES-SO Valais-Wallis (Switzerland)
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Realistic cross-domain microscopy via conditional generative adversarial networks: converting immunofluorescence to hematoxylin and eosin
Paper 11320-27
Author(s): Gouthamrajan Nadarajan, Scott Doyle, Univ. at Buffalo (United States)
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The role of x-ray diffraction imaging in digital pathology
Paper 11320-37
Author(s): Anuj J. Kapadia, Stefan Stryker, Shannon J. McCall, Duke Univ. Medical Ctr. (United States); Joel A. Greenberg, Duke Univ. (United States)
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Conditional generative adversarial network for synthesizing hyperspectral images of breast cancer cells from digitized RGB histology
Paper 11320-29
Author(s): Martin Halicek, The Univ. of Texas at Dallas (United States), Georgia Institute of Technology & Emory Univ. School of Medicine (United States); Samuel Ortega, Himar Fabelo, Univ. de Las Palmas de Gran Canaria (Spain); Carlos Lopez, Marylene Lejaune, Hospital de Tortosa Verge de la Cinta (Spain); Gustavo M. Callico, Univ. de Las Palmas de Gran Canaria (Spain); Baowei Fei, The Univ. of Texas at Dallas (United States)
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Hyperspectral imaging and deep learning for the detection of breast cancer cells in digitized histological images
Paper 11320-30
Author(s): Samuel Ortega, The Univ. of Texas at Dallas (United States), Univ. de Las Palmas de Gran Canaria (Spain); Martin Halicek, The Univ. of Texas at Dallas (United States), Georgia Institute of Technology & Emory Univ. School of Medicine (United States); Himar Fabelo, Raul Guerra, Institute of Applied Microelectronics, Univ. de Las Palmas de Gran Canaria (Spain); Carlos Lopez, Hospital de Tortosa Verge de la Cinta, Institut Català de la Salut, Institut d'Investigació Sanitària Pere Virgili (Spain), Univ. Rovira i Virgili (Spain); Marylene Lejeune, Hospital de Tortosa Verge de la Cinta (Spain), Univ. Rovira i Virgili (Spain); Fred Godtliebsen, UiT The Arctic Univ. of Norway (Norway); Gustavo M. Callico, Institute of Applied Microelectronics, Univ. de Las Palmas de Gran Canaria (Spain); Baowei Fei, The Univ. of Texas at Dallas (United States), The Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Show Abstract
Hyperspectral microscopic imaging for detection of head and neck squamous cell carcinoma using histologic image and machine learning
Paper 11320-31
Author(s): Ling Ma, Martin Halicek, Ximing Zhou, James D. Dormer, Baowei Fei, The Univ. of Texas at Dallas (United States)
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