Intracellular stresses generated by molecular motors can actively modify cytoskeletal network, which causes
changes in intracellular mechanical properties. We study the out-of-equilibrium microrheology in living cells. This paper
reports measurements of the intracellular mechanical properties using passive and optical tweezers-based active
microrheology approaches and endogenous organelle particles as probes. Using the fluctuation-dissipation theorem, we
compared the two approaches measurements and distinguished thermal and non-thermal fluctuations of mechanical
properties in living cells.
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