The application of 5-aminolevulinic acid in the treatment of precancerous lesions, skin cancer, and a new approach to the control of therapy

Paper Abstract

The aim of our work was to determine a therapeutic effect of photodynamic therapy (PDT). Twenty five patients with the Bowen's disease, actinic keratosis and basal cell carcinoma (superficial, nodular) were examined. They were treated with photosensitizer - aminolevulinic acid (metabolized in protoporphyrin IX), and the new red light source built of high-power diodes. A new method, based on numerical analysis of fluorescence imaging of tissues, was proposed as a way for controlling therapy.

This paper was published in SPIE Proceedings Vol. 7161

Photonic Therapeutics and Diagnostics V, Brian J. Wong M.D.; Henry Hirschberg M.D.; Kenton W. Gregory M.D.; Nikiforos Kollias; Reza S. Malek; Bernard Choi; Guillermo J. Tearney; Justus F. R. Ilgner; Steen J. Madsen; Haishan Zeng; Laura Marcu, Editors, 716111