Experimental analysis on the properties of polypyrrole as drug delivery system materials
A quantitative analysis of drug release characteristics of polypyrrole (PPy) was performed for its application to a drug
delivery system (DDS). The incorporation of various chemical substances into the PPy and controlling its release with the externally applied voltage to the PPy are possible. A qualitative drug release characteristics of the PPy was first examined using an indicator, phenolred and then the quantitative analysis was performed using salicylate as a dopant. A drug release characteristics with time was thoroughly investigated while varying the electrode area, polymerization time, the applied voltage for drug release. Based on these quantitative results, a preliminary experiment was carried out to check the feasibility of the PPy applicable to the neuronal system. Experimental results show that a neurotransmitter was released from the PPy with the externally applied voltage and hence the PPy can be applicable in a neuronal system.
This paper was published in SPIE Proceedings Vol. 5051
Smart Structures and Materials 2003: Electroactive Polymer Actuators and Devices (EAPAD), Yoseph Bar-Cohen, Editors, pp.338-348