Renaissance Boston Waterfront Hotel
    Boston, Massachusetts, United States
    3 November 2008
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    Program

    SPIE, in cooperation with Spectroscopy magazine, presents a program featuring top experts discussing the latest developments in spectroscopy.


    9 amSpectroscopy – An Overview
    David Ball

    Professor of Chemistry and Deputy Director of the Honors Program, Department of Chemistry, Cleveland State University
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    Abstract. The author of Spectroscopy magazine’s popular “Baseline” column will give a brief overview of the field of spectroscopy, including its historic contributions to the development of modern science.

       
    9:45 amSpectroscopy: Imagine All the People Using Raman Today and Tomorrow
    Andrew Whitley

    Vice President, Raman Spectroscopy, Molecular and Microanalysis Division, Horiba Jobin-Yvon
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    Abstract. Remember hearing about Raman spectroscopy in graduate school? The vibrational spectroscopy that is sort-of like IR, but done with a laser, and too difficult to be practical. All that has changed. Raman instruments are now small, sensitive, and solve problems that IR and other analytical tools cannot address.

    In the pharmaceutical field Raman is irreplaceable in characterizing drug delivery products. Active ingredient (API) can be monitored in transdermal patches; the movement of the API through the different components can be followed using in-situ confocal techniques. In tablets images of the distribution of the drug and all the excipients can be created from full-spectrum maps. Counterfeit products can be determined from the excipient profile and/or the component distribution of the tablets. Even more importantly, counterfeit tablets with toxic components can be analyzed. For example, the FDA Office of the Forensic Chemistry Center in Cincinatti used their Raman confocal microscope to determine the origin of the 2007 problem in the gluten used in animal food. They identified melamine as the adulterant, but knowing that metamine by itself is not toxic, also identified the presence of melamine derivatives that formed totally insoluble Zwitterions in the kidneys. They were able to produce Raman images of these crystals in kidney histological sections.

    This technology is providing groundbreaking information in other fields as diverse as biomedicine (as an aid to unraveling disease processes) and the production of fuels from biomass. This is in addition to well-proven applications in semiconductor engineering and contaminant identification (during manufacturing), composites, and geology.

    In this talk you will hear about what has already been done, and about new emerging fields. By implication, you will understand why Raman is important today, and you will get a feeling for why it will be even more important tomorrow.

      
    10:15 amFrom the Telecom Boom and Bust Towards Pervasive Spectroscopy
    William Yang, Ph.D.

    President and CEO, BaySpec, Inc.
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    Abstract. Instrumentation professionals have long recognized great potential for NIR, Raman spectroscopic analyzers in many application areas ranging from lab analysis to portable field monitors. Until now, however, NIR, Raman process analytical instrumentation was too big, too expensive, too fragile, and so sophisticated they required highly trained operators for “real-world” application use. Recent advances in high volume telecom device manufacturing presents a disruptive new picture today.

    The state-of-the-art NIR, Raman spectrometer today borrows largely from the massive investments made in telecom grade components over the last ten years. These include: transmission holographic volume phase gratings, linear array image sensors, miniature lasers and light sources, and solid-state computer chips. Collectively, these are now assembled into ultra-compact, no moving parts, low power consumption, hermetic, reliability-tested spectral engines that can run on batteries in a handheld form factor.

      
    10:45 amCoffee Break
     
    11:15 amMiniature Spectrometers: Technologies, Challenges and Opportunities
    Richard Crocombe, Ph.D.

    Business Development Manager, Thermo Fisher Scientific
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    Abstract. There are straightforward motivations for miniaturizing a spectrometer. If an instrument can be made smaller, it will often also consume less power, enabling it to be portable and eventually hand-held. This allows the spectrometer to be taken to the sample, as opposed to the sample to the spectrometer, and this typically leads to increased productivity in traditional applications. Small size often also implies lower cost, and this opens up non-traditional applications, often as a specific analyzer.

    In recent years, improvements in optics, electronics and detectors have enabled the design and manufacture of many small spectrometers. In particular, the massive investment in telecommunications, MEMS (Micro Electro Mechanical Systems) and MOEMS (Micro-Opto-Electro-Mechanical Systems) has impacted the near-infrared and Raman fields, while cell phone developments (DSP processors, portable displays, batteries) are key enabling technologies for any portable analyzer.

    Some of the recently developed instruments, and the technology they use, can be classed as disruptive and may first enable new applications, and later cause some of the existing, mature, technologies and products to disappear from the market.

    This talk will describe the technologies, challenges and opportunities for portable spectrometers and analyzers, including both molecular and elemental techniques.

     
     
    11:45 amApplications of Modern Mini-spectroscopy Systems
    Jason Eichenholz

    Vice President of Research and Technology, Ocean Optics Inc.
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    Abstract. Spectrometer system designs have evolved rapidly over the last 15 years when a major paradigm shift occurred as spectroscopy systems advanced from bulky expensive lab based instrument platforms to the modern compact flexible portable instruments we see today. Thousands of new applications have emerged that were enabled simply by being able to bring the spectrometer to the sample.

    There is tremendous interest in the utilization of modern spectroscopy equipment to solve very challenging technical problems with real world applications. These applications are numerous and diverse ranging from enabling new and more accurate medical diagnostics, to improving the environment and protecting lives from terror threats. As time has progressed, the performance and benefits of these compact systems have improved.

    The recent development of extremely powerful compact microprocessors has enabled a new phase of even more compact spectroscopy systems.

    This talk will provide an overview of the recent technological advances of the mini-spectrometer and an overview of a few selected applications and the real world problems they solve.

     
    12:15 pmLunch
     
    1:45 pm25 Years of Development in ICP-mass Spectrometry
    Steven Beres

    Sr. Scientist, PerkinElmer SCIEX
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    Abstract. The trace element technique of Inductively Coupled Plasma Mass Spectrometry (ICP-MS) has experienced remarkable growth since the first paper was published in 1980. This is primarily due to the fact that it fills a very large need in Inorganic Analysis. The technique has improved steadily since it was first commercialized twenty-five years ago to become a powerful tool for researchers and routine analytical laboratories alike.

    This presentation will provide a brief overview of the technology behind ICP-MS, its analytical capabilities, examine the history of the technique, and discuss significant milestones over the last quarter century.

     
    2:15 pmDealing with the Form of the Sample in Optical Emission Spectrometry (OES)
    Jerry Dulude

    President, Glass Expansion, Inc.
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    Abstract. The optical platform for emission spectrometers has evolved over the past 30 years and is now well accepted. However, the operator must choose from a variety of components that constitute the sample introduction system during the process of developing and optimizing an analytical method.

    The current state of OES instrumentation will be described as will the components of the sample introduction system with an eye toward helping the analyst determine which configuration is optimum for specific sample types.

     
    2:45 pmAdvances in Spectral Imaging Technologies
    Richard Driver, Ph.D.

    Director of Engineering, Headwall Photonics, Inc.
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    Abstract. Innovative spectroscopy instrument designs utilizing hyperspectral sensing and Raman imaging have enabled high performance measurement capabilities for a range of new industries and new applications in areas such as medical diagnosis, biotechnology, process manufacturing, and military & defense.

    This presentation will discuss recent advancements of several hyperspectral and Raman imaging sensor instruments that provide precise spatial and spectral data simultaneously from a wide area field of view. Imaging sensors are optimized for collecting high fidelity spectral data from within small features when viewed through a lens “push-broom” technique, or via high throughput multi-channel fiber optic collection at many discrete measurement points.

     
    3:15 pmCoffee Break
     
    3:45 pmDevelopment of New and Improved Hyperspectral Systems to Enhance Food Safety Inspection
    Moon Kim, Ph.D.

    Senior Scientist, USDA Agricultural Research Service
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    Abstract. The Agricultural Research Service of U.S. Department of Agriculture has developed line-scan spectral imaging systems for rapid online inspection of various agricultural commodities such as poultry carcasses and apples. For poultry carcasses, the spectral imaging system was designed to identify wholesome and unwholesome freshly slaughtered carcasses on high-speed commercial chicken processing lines.

    A combination of fluorescence and reflectance imaging techniques is implemented for the online apple inspection system to achieve safety and quality inspections at high processing speeds. These spectral imaging inspection systems were developed using a high performance spectral imager coupled with an electron-multiplying charge-coupled-device (EMCCD) camera.

    In collaboration with a commercial partner, the line-scan imaging systems have been enhanced to accommodate low-light imaging environments for both hyperspectral and multispectral imaging of rapidly moving targets.

     
    4:15 pmHyperspectral Imaging for Optical Microscopy Applications
    Samuel Lawrence

    CEO, CytoViva
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    Abstract. CytoViva® is a leading provider of advanced optical microscopy and hyperspectral imaging technologies. These technologies have been specifically designed to support research initiatives in the areas of nano-technology, nano-medicine and other bio-medical related areas.

    CytoViva technology advances these research efforts by providing real-time optical imaging of nano-scale materials and live biologicals, simultaneous observation of both fluorescent and non-fluorescent sample features, and Spectral analysis of nano-scale materials and live biologicals.

    CytoViva's advanced optical microscope system creates a high contrast, high signal-to-noise ratio, dark field-based image. This enables fast, easy observation of a wide range of nanoscale materials as well as live cells and pathogens.

     
    4:45 pmMarket Trends and Closing Remarks
    David Walsh

    Editor-in-Chief, Spectroscopy and LCGC North America
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    Abstract. A discussion of trends in research and industry, followed by general thoughts on the day's presentations.