Lai, Puxiang

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Dr. Puxiang Lai

Assistant Professor
Hong Kong Polytechnic Univ

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Area of Expertise: biomedical optics, biomedical ultrasound, optical focusing in tissue, ultrasound-modulated optical tomography, acousto-optic imaging, optic holograhy
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Puxiang Lai had his bachelor’s degree in Biomedical Engineering in 2002 from Tsinghua University, Beijing, China, and his master’s degree in Acoustics in 2005 from the Chinese Academy of Sciences. Between 2005 and 2010, he studied at Boston University for his PhD degree, under the supervision of Prof. Ronald A. Roy and Prof. Todd W. Murray in the Department of Mechanical Engineering. His research at Boston University was concentrated on the development of new biomedical sensing modalities using sound and light, with the aim to improve the spatial resolution of optical sensing in biological tissue. In 2010, Puxiang Lai joined Dr. Lihong Wang’s Optical Imaging Laboratory as a postdoc research associate at the Department of Biomedical Engineering, Washington University in St. Louis. Besides acousto-optic sensing (also called ultrasound-modulated optical tomography) and photoacoustic imaging, he has also expanded his interests to optical focusing inside (not through) thick turbid media with the guidance of focused ultrasound (including ultrasound modulation and ultrasound sensing). Thus far, his projects on this topic have majorly included (1) the development of a reflection-mode time-reversed ultrasonically encoded (TRUE) optical focusing system; (2) the first demonstration of TRUE optical focusing in thick biological tissue; (3) the direct visualization and dynamic control of TRUE optical focusing in turbid media; (4) the demonstration of localized fluorescence excitation and imaging in highly scattering media with TRUE light; (5) the development of a millisecond-order TRUE optical focusing system, which achieves the first optical focusing inside dynamic (moving) turbid media and living biological tissue; (6) the development of ultrasonically-encoded wavefront shaping (SEWS) for optical focusing; and (7) the development of nonlinear photoacoustic wavefront shaping (PAWS) for optical focusing.
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