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Biomedical Optics & Medical Imaging

Changhuei Yang: Computational microscopy improves resolution, field of view

A complete data set derived from low-resolution snapshots could lead to cost-effective autonomous digital pathology.

23 October 2013, SPIE Newsroom. DOI: 10.1117/2.3201310.02

Changhuei Yang is Professor of Electrical Engineering and Bioengineering at California Institute of Technology. His research area is biophotonics -- the imaging and extraction of information from biological targets through the use of light. His research efforts can be categorized into two major groups:

Chip-scale microscopy -- Yang's group is developing a number of technologies aimed at transforming the conventional microscope into chip-scale, automated and cost-effective formats. His group is the pioneer of the first chip-scale microscope system -- the optofluidic microscope. The self-imaging petri dish, ePetri, is the group's most recent major innovation in this research area.

Time-reversal based optical imaging -- His group is working on the use of 'time-reversal' techniques to undo the effect of tissue light scattering. This work has the potential to enable greatly improved depth penetration and resolution improvement for deep-tissue optical imaging. It also opens up the possibility for performing incision-less laser surgery and precision cancer therapy.

Yang joined Caltech in 2003. He has received the NSF Career Award, the Coulter Foundation Early Career Phase I and II Awards, and the NIH Director's New Innovator Award. Discover Magazine named him one of the top 20 scientists under 40 in their list of Best Brains in Science 2008. He is a member of SPIE and has authored or coauthored more than 50 papers in SPIE journals and proceedings.