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All Technical Articles - Biomedical Optics & Medical Imaging

All Newsroom Technical Articles, starting with the most recently posted:

Jennifer Douris O’Bryan

Quantum, AI, Navigation, and Biotechnology are among the listed technologies (updated)

12 December 2018
Andrew Forbes Lab

Andrew Forbes of University of Witwatersrand on photonics, globe-crossing collaborations, and the pleasures of mentorship.

5 December 2018

A chat with Alejandro Rodriguez of Princeton's Nanophotonics Design and Computation Group.

29 November 2018
Lasing everywhere

Malte Gather's Soft Matter Photonics group at University of St. Andrews is working on technology that will allow you to shoot laser beams out of your eyes.

21 November 2018
Manijeh Razeghi

"Look inside the tiniest of particles and you will find a universe." - Rumi (1207-1273), quoted on the back of Razeghi's "Fundamentals of Solid State Engineering" (2nd edition).

15 November 2018
PW childcare grant

SPIE has created a grant to give parents equal opportunity to attend its largest annual meeting.

1 November 2018
Augmented Reality for Breast Cancer Research

Augmented reality helps surgeons make decisions in real time.

30 October 2018
AI breast imaging

Sophisticated artificial intelligence algorithms are revolutionizing breast cancer screening.

22 October 2018

Conformable arrays of tiny polymer electrodes may improve care and outcomes for epilepsy patients.

11 October 2018
Lihong Wang

An innovative breast-imaging technique offers noninvasive options for multiple biomedical applications.

1 October 2018
Human factors

The importance of human factors in medical imaging.

1 October 2018
Jennifer Douris O’Bryan

The US Trade Representative has announced a process for US companies to request permission to continue importing targeted items on a duty-free basis.


7 September 2018
Marks_SMART bandage

Photonics for a Better World

8 August 2018

Halina Rubinsztein-Dunlop on mammalian-like zebrafish brains, the optical tools in her research kit, and her favorite role model.

31 July 2018
GDPR logo from July18 SPIE Pro

In an effort to be 100% GDPR compliant and transparent about data collection policies, SPIE updated its Privacy Policy.

1 July 2018
SPIE CEO Kent Rochford

SPIE's new CEO Kent Rochford, formerly of NIST, stepped into his new role 1 June. We asked Rochford to discuss his views on SPIE and the world of optics and photonics.

11 June 2018
Quantum Tech_cover of SPIE Pro

Devices using quantum technologies are reaching milestones.

6 April 2018
EU regulations

EU-RoHS task force seeks help from the optics and photonics community.

31 April 2018
SPIE PW orange

An industry panel at SPIE Photonics West 2018 discusses the future of additive manufacturing.

28 March 2018
SPIE Photonics for a Better World logo

Photonics for a Better World.

26 March 2018
SPIE Women in Optics logo

A Women in Optics presentation from SPIE Photonics West 2018.

22 March 2018
SPIE PW orange

An interview from SPIE Photonics West 2018.

21 March 2018

World's oldest dedicated university optics center celebrates a hundred years of optics-related research and education, but notes the need to widen participation.

19 March 2018

New imaging tool for recording changes over time, space, and function

16 March 2018
Ovsianikov_PW presentation

A presentation on 3D printing and bioprinting with multiphoton lithography from SPIE Photonics West 2018.

11 March 2018

From the SPIE Photonics West Show Daily: Quantum technology on exhibit at Moscone Center.

7 March 2018
SPIE PW orange

Since its invention near the turn of the century, the optical frequency comb has heralded a new era in optical frequency measurements.

5 March 2018
SPIE logo

The Photonics West Show Daily spoke with recruiters and students about the optics and photonics job market.

26 February 2018

Can quantitative phase imaging help combat dementia and find a cure for cancer? The technology is set but developers need to increase awareness among biologists, hears Rebecca Pool.

19 February 2018

From precision components in breathtaking timepieces to micro-needles for vein cannulation, breakthrough laser writing from Photonics West exhibitor Femtoprint is reshaping microdevice fabrication.

16 February 2018

SPIE, one of seven international organization members of the International Commission for Optics, has supported the mission of the organization for many years.

14 February 2018
optics key challenge_thumb

A new conference incorporating interactive experience at Photonics West reveals the rapid growth of augmented and virtual realities. Its chair, Bernard Kress of Microsoft's Hololens division, tells Matthew Peach that optics remains the key challenge in developing the ultimate virtual experience.

9 February 2018

SPIE is collaborating with other organizations to host grand challenge events aimed at solving problems in medical imaging.

7 February 2018
SPIE PW orange

R&D highlights from the 2018 session: Presentations from leading researchers in biophotonics.

5 February 2018
SPIE PW orange

A day-long industry conference at SPIE Photonics West highlighted optical technological challenges and successes for VR, MR and AR.

31 January 2018

Taking a path less traveled by women.

29 January 2018
SPIE logo

The 2018 SPIE President shares her career path, education, and other interests with the members of SPIE.

27 January 2018
SPIE logo

Since its inception in 1955, SPIE has focused on providing a conduit for ideas in photonics and optics in a growing and vibrant global marketplace.

26 January 2018

By placing quantum dots on top of graphene, a highly sensitive photodetector is constructed that works simultaneously for visible and IR light.

26 January 2018

Optics plays dominant role in medical imaging market.

22 January 2018

SPIE Classics celebrates 25 years of research and development in optical coherence tomography.

10 January 2018

Integrating highly efficient energy conversion materials onto stretchable and biocompatible substrates could yield breakthroughs in implantable biomechanical energy harvesting systems.

21 July 2011

Innovative imaging techniques as well as teaching methods have helped advance research at the biophotonics laboratory at Vanderbilt University.

15 June 2011
Smaller, faster, cheaper optical biosensors offer the capacity to provide effective and actionable information.
28 April 2011
Boyden's award-winning research has led to tools that can activate or silence neurons with light, enabling the causal assessment of how specific neurons contribute to normal and pathological brain functions.
21 April 2011

A turkey carcass played a key role in discovering the potential of the argon-fluoride excimer laser at 193 microns and its eventual widespread application in eye surgery.

4 April 2011
Using stimulated emission depletion microscopy and other techniques, Stefan Hell explores new ways to examine living cells noninvasively.
1 April 2011
Mark ReaSolid-state lighting and the discovery of a new photoreceptor in the brain have stimulated the study of how light impacts biological systems.
15 March 2011

Based in Jena, the birthplace of optical technology in Germany, JENOPTIK's Michael Mertin has a unique perspective on the industry's past and future.

28 February 2011
Audio recordings and slides from plenary presentations at SPIE Photonics West 2011.
7 February 2011

Clinical Multiphoton Tomography - Karsten Koenig presentation from BiOS Hot Topics session at SPIE Photonics West 2011

31 January 2011

New Developments in OCT for Ophthalmology - David Huang BiOS Hot Topics presentation at SPIE Photonics West 2011

31 January 2011

Training more high-school physics teachers and increasing student learning are two of the challenges facing math, science, and engineering education in the United States.

17 December 2010
The vice president of engineering at CVI Melles Griot Laser Group talks about the company's evolution and efforts to serve the biomedical instrument market.
19 November 2010
With properties that don't exist in nature, metamaterials open up an exciting range of possibilities.
10 November 2010
The father of the FEL talks about current research and potential applications of the technology, from genetics to defense and security.
19 October 2010
Tissue pathology can be detected in vivo by optical methods through minimally invasive endoscopy. Work at the BC Cancer Agency in Vancouver is focused on Raman spectroscopy of internal and external surfaces.
16 July 2010

In his lab at Oregon Health and Science University, Jacques and his researchers have developed new modalities for diagnosis and treatment. He reflects on the laser's key role.

26 May 2010

Nozomi Nishimura explains how researchers use femtosecond laser pulses to model and study the effects of stroke and Alzheimer's in brain cells.

30 April 2010
Katarina Svanberg laser interviewLasers have a multifaceted role in oncology, and have increased patient survival through their use in tumor detection and treatment.
16 April 2010

The clinical uses of PDT have expanded, and research is underway on a variety of cancers as well as infectious diseases.

19 March 2010

The SPIE 2010 Gold Medal winner reminisces about the formative years of the laser, and talks about new horizons in science.

26 February 2010
The chief technology officer of LightLab Imaging talks about the company's efforts in developing optical coherence tomography products for clinical use.
25 February 2010
The first integrated-circuit vocal tract, combined with a bionic ear processor in a feedback speech-locked loop, provides a new way to process speech.
3 February 2010

Nanoscopy with Focused Light - Stefan Hell plenary presentation from SPIE Photonics West 2011

31 January 2010

Novel Uses of Femtosecond Laser Pulses in Biophotonics - Eric Mazur presentation from the BiOS Hot Topics session at SPIE Photonics West 2011

31 January 2010

In this 10 minute presentation from the BiOS Hot Topics session at Photonics West 2011, Ed Boyden talks about his research at MIT.

31 January 2010
Jim Fujimoto works with students and patients to expand the clinical applications of biomedical optics.
21 January 2010
Leon Esterowitz completed his PhD in the early 60s in the early days of the laser. After a career in defense, he moved to NSF, and now reviews funding proposals in biophotonics.
13 January 2010
Rox Anderson, symposium chair of SPIE Biomedical Optics at Photonics West, talks about the important role of lasers in medicine, from cancer to heart disease and his own specialty, dermatology.
5 January 2010
Integration of biological molecules into nanoelectronic devices promises new, sophisticated biointerfacing technologies.
9 December 2009
A new method for killing viral particles may have important medical applications like disinfecting blood components and treating diseases.
3 December 2009
Automated classification of individual blood-vessel abnormalities may improve the efficiency of a common test for autoimmune diseases.
18 November 2009
Combining a post-acquisition rearrangement procedure with optical coherence tomography can provide high temporal resolution for capturing subtle dynamics in the early avian embryonic heart.
17 November 2009
Spectral-domain optical coherence tomography performed simultaneously in two distinct wavelength bands permits better diagnosis of tumors.
9 November 2009
High-frame-rate, real-time laser Doppler imaging of biological tissue uses advances in optical sensing and processing.
30 October 2009
Using light to inject a single nanosized biosensor into a mammalian cell enables analysis of its biochemistry.
20 October 2009
The combination of microfluidics and plastic electronics could bring laboratory-quality analysis to the practitioner in the field.
16 October 2009
A new technique to remove complex-conjugate artifacts inherent to conventional Fourier-domain interferometry can double accessible imaging depth.
13 October 2009
An electro-optic lens with voltage-controlled focusing power across the aperture takes a new approach to adjusting vision as people age.
6 October 2009
Bioinformatic techniques enable identification of extremophile life forms well adapted to extraterrestrial environments such as Mars.
30 September 2009
A proposed model for migrating birds' magnetic sense can withstand moderate orientational disorder of a key protein in the eye.
23 September 2009
Transduction of molecular recognition by closely packed organic electronics and membrane proteins may enable accurate, label-free diagnostic testing.
23 September 2009
Determining the characteristic quadratic hyperpolarizability of amino acids for single molecules and short peptides enables advances in tissue imaging.
23 September 2009
Optical coherence microscopy has potential as a tool for noninvasively measuring electrical activity in single neurons based on changes in their intrinsic optical properties.
16 September 2009
Combining organic lasers with optical waveguides and microfluidic channels may enable inexpensive, disposable diagnostic tests that can be analyzed at the patient's bedside.
15 September 2009

From fabric that can process images to laser communication to brain surgery, Yoel Fink of MIT describes some of the uses of multimaterial fibers.

9 September 2009
Ancient weathering crusts are often the only source of information about the conditions under which development of our biosphere occurred.
4 September 2009
The former president of MIT spoke at the SPIE Optics + Photonics Symposium Awards Banquet.
13 August 2009
A wavelet method that employs Monte Carlo ray sampling fully accounts for diffraction and interference in complex media.
7 August 2009
Fluorescent probes enable nondestructive, in situ microscale viscosity measurements.
7 August 2009
The fabrication process can reduce multiple scattering effects and decrease pixel size, paving the way for improved x-ray, charged particle, and neutron detectors.
5 August 2009
Photodynamic therapy represents a paradigm shift in oncological medication from traditional resection and systemic chemotherapy methods.
22 July 2009
A large, dynamic-range Shack-Hartmann wavefront sensor allows the characterization of higher-order aberrations in keratoconic and post-corneal transplant eyes.
21 July 2009
Selective electrolysis of phosphate-buffered saline may provide oxygen directly to retinal tissue with minimal coproduction of harmful free chlorine.
15 July 2009
Characterizing how nanoparticles affect organs and accumulate in tissue may provide insight into their safety as a potential cancer therapy
15 July 2009
Polarization-sensitive optical coherence tomography enables tissue-sensitive visualization of the front of the eye.
9 July 2009
Improved understanding of the fundamental cellular and molecular mechanisms is broadening the technique's mainstream use for many ailments.
9 July 2009
A novel approach enables user-defined manufacture of biocompatible and biodegradable polymer structures for regenerative medicine.
6 July 2009
A new system for ultrahigh-speed imaging of the anterior segment of the eye retains micrometer resolution.
6 July 2009
Growing indium nitride film in a different orientation paves the way for noninvasive analysis of chemical composition.
1 July 2009
A new class of photonic-crystal fiber with a hollow core and various lattice modifications may be an important component for biosensing applications.
30 June 2009
A new data-capture method could provide increased flexibility for clinical imaging applications.
30 June 2009
A computerized tool gives radiologists a second opinion for diagnosing breast cancer.
30 June 2009
A new family of chemical labels with much longer lifetimes than traditional fluorophores are key to a new biological imaging method: time-resolved emission imaging microscopy.
24 June 2009
Intensity-based Doppler optical coherence tomography gives an accurate, high-speed, 3D readout of ocular blood flow.
24 June 2009
Sub-Angstrom-resolution sensing of tiny cantilevers is leading the way to a gentle physical probe for surfaces of materials such as living cells.
19 June 2009
Detailed, real-time imaging allows for adjustment of surgical margins, thus sparing healthy tissue and increasing the likelihood of complete tumor removal.
19 June 2009
Pressure waves caused by nanosecond laser pulses can be used to deliver macromolecules to cells and tissues.
16 June 2009
A new technique for monitoring blood flow will help investigate eye functions and retinal disease.
10 June 2009
Top SPIE Newsroom articles from the previous month, and papers from SPIE Journals and Conference Proceedings.
9 June 2009
Monitoring biochemical interactions can serve as the basis for many diagnostic techniques.
5 June 2009
A hybrid magnetic-resonance/fluorescence imaging system aids identification and study of tumors.
1 June 2009
By using optical nanocavity resonators, the interaction between the light and target molecules is enhanced more than a million times, leading to improved single-molecule detection.
26 May 2009
Laser-induced ultrasound can aid the early detection and monitoring of metastatic disease.
22 May 2009
Very detailed 3D scans of a 3000-year-old mummy of an Egyptian temple singer and priestess are made freely available for in-depth follow-up studies.
18 May 2009

Long wavelength light permits in vivo imaging of the human eye at a cellular scale.

18 May 2009
Electronics, sensors, and communication capabilities will all be embedded in future contact lenses, presenting new opportunities in applications ranging from medicine to virtual reality.
15 May 2009
A combination of waveguides and microfluidics is easily achieved through femtosecond-laser micromachining.
14 May 2009
By exploiting the extra information available from 3D imaging in a virtual reality environment, surgeons can individualize the pre-planning of surgery on the kidneys.
13 May 2009
Blindly separating images prior to applying tissue-contrast-enhancing algorithms shows clear improvements over current techniques.
12 May 2009
Innovations in photonics and microfluidics have enabled the development of a novel, rapid, sensitive, low-cost, and portable micro-gas analyzer.
4 May 2009
Recent advances in imaging technology facilitate cellular-resolution retinal imaging and wide-field 3D visualization, enabling enhanced penetration below the retina for routine diagnosis.
3 May 2009
This patent review from Nerac explores some new developments in retinal implants that may speed their acceptance for treating blindness.
1 May 2009
The successful demonstration of near-IR contrast agents brings non-nuclear diagnosis closer to clinical use.
29 April 2009
A combination of polarization and Doppler-flow imaging for optical coherence tomography enhances image contrast without sacrificing acquisition speeds.
24 April 2009
A Web-accessible, content-based system for searching a large cervigram database may play an important role in medical education and cervical-cancer research.
14 April 2009
A device combining optical coherence tomography and adaptive optics can capture micron-scale 3D pictures of the retina.
6 April 2009
Optical coherence tomography enhances clinical diagnosis and could increase our understanding of major disease progression.
25 March 2009
Even after multiple applications of sunscreen, the UV-blocking particles remain localized close to the skin surface and produce insignificant numbers of free radicals.
23 March 2009
Advances in monitoring the response to photodynamic therapy may permit real-time dosage adjustments, improving the outcome for patients.
17 March 2009
Individuals and organizations must work together to reduce pediatric radiation exposure.
13 March 2009

Margaret Wertheim describes her work on the Institute for Figuring.

3 March 2009
Diffusion imaging already offers an unprecedented view of the human brain's structure, but it is still an evolving field, providing opportunities for future technical and scientific developments.
3 March 2009
An advanced imaging technique has both the spatial and temporal resolution to investigate the developing heart in important animal models such as chicks and mice.
24 February 2009
Innovations in microfluidic technologies enable rapid in vivo studies employing two-photon microscopy and femtosecond laser nanosurgery.
24 February 2009
Near-IR fluorescent dye encapsulated in calcium-phosphate nanoparticles maintains enhanced brightness for up to four days in human breast-cancer tumors systemically injected into live mouse models.
9 February 2009
Satellite sensors track sources of desert dust for models that predict particle entrainment and atmospheric pollution, resulting in new tools to support public safety and health services.
9 February 2009
Plasmon coupling facilitates detection of direct contacts between optically colocalized gold nanoparticles in optical wide-field microscopy.
9 February 2009
A new operating regime for rapidly wavelength swept, narrowband light sources has enabled high-performance biomedical imaging.
3 February 2009
A tensor method applied to diffusion images provides better reconstructions of nerve fiber crossing than linear methods.
30 January 2009
See-through fish embryos help to demonstrate the advantages of an integrated approach in testing how small particles can alter living organisms.
23 January 2009
Novel fluorescence lifetime-based instrumentation and methodologies enable the development of near-real time clinical diagnostic devices for heart disease and tumors.
21 January 2009
Optical trapping and manipulation of carbon nanotubes using optical tweezers leads to next-generation photonic force microscopy.
19 January 2009
A water-resistant surface inspired by the lotus leaf could enable applications in microfluidics, underwater coatings, and controlled deposition.
19 January 2009
A sparse image model combined with a novel nonlinear reconstruction algorithm can obtain high-quality imaging with significantly fewer measurements than traditional approaches.
15 January 2009
Advances in optical-coherence tomography may lead to a new class of endoscopic, image-guided therapies that target disease with microscopic precision.
15 January 2009
Optical imaging systems that identify molecular signatures of cancer can address clinical needs in both the developed and the developing world.
15 January 2009
Illuminating bodily tissues with a digital micromirror device enables non-invasive characterization of living tissue based on chemistry and morphology.
31 December 2008
Combining semiconductor technology with photonics, optics, and biochemistry leads to sensors with improved biomedical diagnostic capability.
31 December 2008
An innovative single optical fiber configuration in medical probes promises unique capabilities for clinical diagnostics.
28 December 2008
A new diode-pumped solid-state laser offers the technology to complete the triad of red, green, and blue sources needed to produce full-color images.
24 December 2008
Microfabrication and assembly techniques can build high performance miniature microscopes for clinical diagnostics.
22 December 2008
Tools employing low-energy radiation are being developed for clinical applications where knowing the full extent of disease is vital.
16 December 2008
Semiconductor devices based on high-electron-mobility transistors can be functionalized for specific applications.
16 December 2008
Computed tomography colonography employing partial volume image segmentation improves detection of the colonic mucosa layer and thus of potentially cancerous polyps.
15 December 2008
Ablating a biological sample leads to atomization of a small amount of material in a hot, light-emitting plasma that can then be effectively analyzed.
15 December 2008
A near-IR-based portable device can identify and localize suspected brain bleeding in trauma patients.
15 December 2008
Integration of highly sensitive photonic biosensors and microfluidic technologies provide new possibilities for molecular diagnostics.
3 December 2008
A model that captures how people view a multilayer 3D terrain may lead to better visualization schemes.
1 December 2008
Combining broadband near infrared spectroscopy and magnetic resonance imaging of breast tissue allows more accurate quantification of the constituents in suspected tumors.
1 December 2008
Quantum-dot nanoprobes enable real-time quantitative noninvasive assessment of epidermal growth-factor receptor in animals transplanted with human cancer cells.
24 November 2008
By raising the temperature in tumors, optically activated nanoparticles can make existing treatment more powerful.
17 November 2008
A physical model of image formation combined with a reconstruction algorithm results in superior optical projection tomography reconstructions.
6 November 2008
Computational approaches to optoacoustic tomography allow optimization of imaging systems for biomedical applications and efficiency testing of image-reconstruction algorithms.
5 November 2008
Advances in background-noise reduction lead to ultrasensitive protein and DNA sensors for detecting oral cancer.
22 October 2008
Observing surface-texture evolution of nanocrystalline films in situ using reflection high-energy electron diffraction aids in creating novel nanostructures.
20 October 2008
Nanoparticles doped with lanthanides such as holmium and thulium possess useful optical properties for a range of applications including computer displays, lasers, and bioimaging.
15 October 2008
Feedback control systems combine models and experimental data to guide thermal treatments of tumors.
6 October 2008
A new fiber-based probe may enable surgeons to simultaneously view and eliminate individual cells.
6 October 2008
Combining light and ultrasound in a single hybrid technology enables multiscale, high-resolution imaging deep into biological tissue.
22 September 2008
Quality of life studies after laser eye surgery complications may provide impetus to further improve technology.
5 September 2008
First principles in quantum mechanics reveal nature's upper boundary concerning the speed and efficiency of optical technologies, with practical consequences for electro-optics devices and applications.
29 August 2008
Extract, quantify, and interpret intrinsic tissue polarimetry characteristics using a novel Mueller matrix decomposition approach.
29 August 2008
Minimally invasive microsystems employing flexible, thin, compliant substrates and optical or electrochemical detection methods can monitor a wide variety of biomolecules just under the skin surface.
20 August 2008
A new 3D computational approach constructs realistic optical phase contrast microscope images of gold nanoparticles in biological cells.
19 August 2008
New two-photon–activated porphyrin designs allow specific, noninvasive targeting of subcutaneous tumors several centimeters below the skin surface.
14 August 2008
Adding a special lens between an object and a conventional optical microscope can improve image resolution to below the diffraction limit at visible wavelengths.
1 August 2008
New magnetic resonance imaging processing tools allow white-matter fiber bundles to be segmented and tracked in regions of high complexity.
30 July 2008
The detonation of silica-gold nanoshells at energy levels safe for normal tissues and their unprecedented low threshold for vapor bubble formation in solution highlight an advance in cell-killing nanotechnology.
11 July 2008
The in vivo study of the melanin absorption spectrum offers promises of characterizing melanin and associated pathological conditions in their native environment.
8 July 2008
Decay profiles of the local fluorophore environment can provide new opportunities to study biological tissue and cell signaling.
7 July 2008
Advanced imaging near the surface of tissues could assist the development of novel therapeutic agents, drug delivery systems, and diagnostic tests.
20 June 2008
A new approach to automatically identify individuals offers a high level of security while reducing the noise.
17 June 2008
A novel approach to noninvasive assessment of suspicious lesions promises better results with potential for immediate clinical application to tumor diagnosis.
11 June 2008
A project based on biophysics aims to improve the diagnosis, planning, and treatment of cardiovascular disease.
1 June 2008
High-resolution imaging and guidance using optical coherence tomography (OCT) can transfer diagnostic capabilities from the pathology lab to the operating room, enabling real-time tissue visualization and point-of-care decisions.
31 May 2008
The new class of contrast enhancement agents can be precisely tuned to aid in vivo photoacoustic tomography.
12 May 2008
A gray-scale mask for x-ray lithography, made using microelectromechanical systems technology, offers a new approach to manufacturing needle arrays.
5 May 2008

David A. Benaron, CEO of Spectros, has enjoyed a successful career as a physician, researcher, inventor, innovator, and serial entrepreneur by staying focused on the market.

5 May 2008
Polychromatic light-emitting diodes that incorporate 3D faceted microstructures provide good control of color, including pure white emission, without depending on phosphors.
29 April 2008
A device that combines an avalanche-mode amorphous selenium photoconductor with a field-emitter-array readout could provide high-resolution x-ray images at low doses.
29 April 2008
Increased temporal sampling rates make it feasible to quantify lung perfusion using 4D computed tomography.
15 April 2008
Hyperspectral methods using acousto-optic and digital micromirror devices have the potential to improve imaging speed and accuracy with an expanding range of uses, including clinical diagnostics.
15 April 2008
A high-power fiber-based spontaneous emission light source with a tunable filter can be ideal for Fourier-domain optical coherence tomography systems used in biomedical applications.
10 April 2008
Microchambers in photostructurable glass enable the dynamic observation of aquatic microorganisms.
7 April 2008
Wavelength-selectable high-peak-power picosecond optical pulses yield more detailed imaging of biological tissues.
30 March 2008
An assessment method that incorporates focal-spot blurring and scattered radiation optimizes the performance of a fluoroscopic detector.
27 March 2008
Innovative applications include terahertz pulsed spectroscopy for solid-state analysis and terahertz pulsed imaging for tablet coating analysis.
25 March 2008
Using a 4D computed tomography technique, it is possible to trace a tumor's 3D trajectories during a breathing cycle, increasing the probability of a successful treatment.
21 March 2008
In 3D ultrasound images, the ribs can be used as the pivotal reference point for defining the breast region.
13 March 2008
Quantifying placental calcification and infarction aids the obstetrician in assessing these well-established indicators of potential complications.
5 March 2008
Preliminary results from an automated system for analyzing breast lesions suggest that it performs comparably to a breast radiologist.
5 March 2008
Biomolecular motors enable active transport in biology, potentially making possible active materials capable of rearranging their components, or even molecular conveyor belts and forklifts for manufacturing at the nanoscale.
27 February 2008

A low-noise silicon hard x-ray imaging device promises improvement over conventional technologies for future astronomical missions and medical applications.

26 February 2008
Optical approaches provide robust and relatively non-invasive methods for excitation and detection of the motion of micro- and nanomechanical structures.
25 February 2008
The implementation of a JPEG2000 Interactive Protocol–based communication system allows rapid access to high-resolution medical images from low-power handheld devices.
25 February 2008
Near-IR light treatment modifies cellular function, promotes cell survival, and improves outcomes in laboratory and mouse models of Parkinson's disease.
24 February 2008
Micro x-ray imaging tracks nutrients pumped though porous synthetic tissue scaffolds by rhythmic squeezing.
22 February 2008
A stationary tomosynthesis mammography system with a carbon nanotube-based x-ray source array can shorten imaging time and improve image quality.
20 February 2008
Linking changes in arterial microstructure with fluid dynamics of blood flow provides a detailed account of how aneurysms develop.
15 February 2008
A computer-aided detection system uses sagittal proton-density-weighted magnetic resonance images to detect meniscal tears in the knee.
13 February 2008
Novel swept light sources find applications in optical coherence tomography imaging systems.
5 February 2008
A digital holographic technique has an extended measurement range and improved resolution at infrared wavelengths.
4 February 2008
Femtosecond pulse technology can isolate and penetrate embryonic cells for delivery of nanoparticles and DNA.
28 January 2008
Longer wavelengths from a tunable laser improve performance for angioplasty, lithotripsy, and mass spectrometric protein analysis.
26 January 2008
High-sensitivity compact gas-sensing devices may soon replace current bulky detectors used in industry and medicine.
10 January 2008
A large surface area with easily modified chemistry makes porous silicon an effective transducer for optical biosensing.
10 January 2008
Focus engineering of coherent anti-Stokes Raman-scattering microscopy enhances biomedical imaging capabilities.
9 January 2008
A new technique for targeting viral capsids may be applicable to a wide variety of pathogens.
21 December 2007
Extremely thin, flat plasma lamps can illuminate broad areas and have potential applications in medicine and other fields.
19 December 2007
Using a common chemical reaction to produce an easily detected gas simplifies the measurement of breath acetone for medical diagnostics.
6 December 2007
A low-cost, noninvasive means of imaging red blood cells shows promise in applications aimed at assessing tissue viability.
2 December 2007
Microsystem technology is an emerging approach to flow cytometric blood cell analysis based on impedance, fluorescence and light scattering measurements.
19 November 2007
Throwaway devices may be the key to bringing high-performance sensors to market for use in medical applications.
6 November 2007
With minor system modifications and the addition of a high-repetition-rate laser, a commercially-available ultrasound imager can produce optoacoustic images for medical applications.
6 November 2007
The new operating rooms of Varese Town Hospital incorporate a computerized image acquisition and distribution system that can be used in medical education.
25 October 2007
The spatial conformation of surface-bound biomolecules is clarified using a new sensor that could prove useful in biomedicine.
25 October 2007
Ultrasound-induced modulation permits the collection of fluorescence images from deep within light-scattering media.
3 October 2007
The use of digital optics to compensate for aberrations simplifies the digital holographic microscope while increasing the accuracy and resolution of full-field phase measurements.
3 October 2007
Two-photon fluorescence microscopy can be used for non-invasive skin cancer diagnostics and topical drug delivery investigations.
30 September 2007

Early diagnosis increases the likelihood of effective cancer treatment. Nanotechnology offers several ways to improve patient outcomes.

14 September 2007
A wireless address event representation protocol could find use as a low-power, asynchronous system to record neural activity and act as an interface between prosthetic devices and the brain.
10 September 2007
Combining Raman spectroscopy with chemometric analysis allows the rapid identification of single microbial cells without the need for time-consuming microbiological cultivation methods.
5 September 2007
Microdialysis may offer advantages over current methods of performing essential blood measurements by sampling intracellular fluid with a catheter placed beneath fatty tissue.
27 August 2007
Mass spectrometry can be used to identify the biomolecular species present in laser-ablated material from bone and teeth.
23 August 2007

Harold Szu discusses wellness engineering and how technology developed for the military can help monitor diseases such as diabetes.

16 August 2007
A fast-response integrated opto-chemical sensor system can detect ultra-low concentrations of ammonia with high reproducibility.
8 August 2007
Total-internal-reflection fluorescence can be exploited to study real-time biomolecular binding processes with enhanced signal-to-noise ratio.
1 August 2007
The imaging of axonal fibers and connectivity in the human brain are improved by grouping anatomically similar fibers.
31 July 2007
Eye aberration measurements can be used in wavefront-guided laser ablation and clinical research applications.
25 July 2007
Create personalized computer eye models to simulate an individual's vision quality using optical and mechanical engineering software.
17 July 2007
Offering possible advances in everything from computing to spectroscopy, plasmonics represents a powerful technology.
16 July 2007
Nanometer-sized gold particles interacting with electromagnetic fields, fluids, and biological objects can be visualized using a specialized imaging technique combined with dark field microscopy.
4 July 2007
By providing an integrated approach to alleviate the current fragmentation of relevant information, a novel data management system will have a major impact on the treatment of cerebral aneurisms.
26 June 2007
Rats with genetically encoded color probes such as green and red fluorescent protein have been developed for specific biomedical research applications.
21 June 2007
A 3D extension of the standard will support cuboid volumetric data sets with no time component.
19 June 2007
A new approach in optical architecture promises small-scale, high-resolution in vivo imaging for medical applications.
29 May 2007
A microdevice equipped with polarizing filters and an organic photodiode enables detection of dye concentrations in the low nanomolar range.
23 May 2007
A variety of alternative approaches to 3D microscopic imaging can overcome various shortcomings and expand the range of areas and applications.
13 May 2007
Digital off-axis holography with coherence-domain depth gating can measure subcellular motion inside tumors that respond to anticancer drugs affecting the cytoskeleton.
13 May 2007
A smart microfluidic control system that is capable of monitoring clinically-relevant parameters can sample, dispense, and deliver biological fluids to a sensing unit.
10 May 2007
Theodore Maiman, who died in May 2007, is known for creating the first working laser out of a discredited material -- ruby -- in May 1960.
9 May 2007
The two-photon-polymerization process may be used to create medical devices such as middle ear prostheses that are specific to individual patients.
4 May 2007
Automatic search and retrieval methods applied to a large brain dataset can extract valuable additional information.
4 May 2007
Incorporating gold nanoparticles into viral protein provides a tool for studying viruses.
5 April 2007
High-resolution optical coherence tomography serves both as a noninvasive observation method and a therapeutic tool in chronic skin diseases such as scleroderma.
3 April 2007
Anisotropic surface roughness enhances the bending response of ionic polymer-metal composite artificial muscles.
30 March 2007
The noted researcher in biomedical optics discusses new imaging techniques involving nanotechnology, plasmonics, and the use of molecular sentinels for biosensing and diagnostics.
27 March 2007
An improved technique for selecting and immobilizing biomolecules in microstructures promises more-effective patterning of proteins and cells for microtechnology applications.
22 March 2007
Combining spectroscopy and imaging with computational pattern recognition may provide a fast, non-invasive way to detect and diagnose diseases near the body surface.
22 March 2007
A laser-based technique can monitor sap flow in trees, solving a long-standing problem in plant biology with additional implications for climate change modeling.
20 March 2007
Laser gas analyzers are an efficient way to study variations in gas-exchange processes between vegetation and the atmosphere under anthropogenic stress.
20 March 2007
Laser-induced explosion of absorbing nanoparticles, so-called nanobombs, can kill cancerous cells.
20 March 2007
Double-clad photonic crystal fibers and microelectromechanical mirrors significantly improve the sensitivity and miniaturization of nonlinear optical endoscopes.
20 March 2007
A laser-based technique can monitor sap flow in trees, solving a long-standing problem in plant biology with additional implications for climate change modeling.
20 March 2007
A low-cost retro stereoscope for virtual reality and other immersive applications uses flat-panel LCDs and achieves high field-of-view with high resolution.
20 March 2007
Birefringence and transparency of selected liquid crystals at terahertz (THz) frequencies promise added functionalities for liquid-crystal-based THz photonic elements such as phase shifters and filters.
20 March 2007
This month's featured patent review by analysts from Nerac
12 March 2007
RF-controlled battery-less microvalves are fabricated on a biocompatible substrate that allows for communication and remote actuation.
5 March 2007
New photodynamic cancer therapies combine the tumor detection and imaging capabilities of nanoparticles with the increased penetration depth of infrared two-photon excitation.
27 February 2007
Lateral shear interferometry combined with digital holographic microscopy can provide quantitative optical phase measurements with the use of a new, single image, reconstruction procedure.
20 February 2007
Varying pH makes it possible to control conformational changes of polymer chains attached to stimuli-responsive interfaces.
19 February 2007
The light-scattering signatures of bacterial colonies, which depend on minute genetic differences, may provide a way to rapidly identify pathogens in the food supply.
16 February 2007
As temperature changes, the change in backscattered ultrasonic energy is nearly monotonic, thus potentially enabling noninvasive 3D temperature imaging.
12 February 2007
In this video of his Photonics West presentation, David Krohn shares expert advice and perspective on the market potential, technology, opportunities and barriers in biophotonics.
5 February 2007
Polymer layers for microarrays patterned by laser ablation adsorb biomolecules only in specified regions and improve solid-phase transfection of cells when a voltage is applied.
5 February 2007
Optical interferometry reveals tiny motions in live cells that convey information about membrane properties and disease.
4 February 2007
Combining time-resolved photon counting, scanning optical techniques, and atomic force microscopy provides new tools for single-molecule investigations.
30 January 2007
Infrared spectroscopy combined with statistical analysis can identify and discriminate among vegetative bacteria, bacterial spores, and background interferents.
29 January 2007
A novel band selection technique developed for feature extraction of hyperspectral images uses a heuristic optimization algorithm.
29 January 2007
A thin-walled glass microfluidic channel can incorporate multiple optical ring resonators around the capillary diameter to act as sensors on a high-throughput lab-on-a-chip platform.
25 January 2007
Combining a deformable mirror with a super-resolution algorithm enables higher-resolution images from a relatively simple system.
22 January 2007
A new viewer can form enhanced pictures of objects in the dark, without the use of a camera or display.
18 January 2007
Thermal lens microscopes and microchemical chips aid in miniaturizing functional chemical laboratories.
18 January 2007
The high circulating intensities in ultrahigh-Q optical microresonator sensors improve their sensitivity enough to detect a part per million of heavy water in water.
8 January 2007
Technology developments have enabled the deployment of hyperspectral sensors to new application areas.
4 January 2007
An antibiotic can mitigate low-intensity microwave damage to red blood cells by reorganizing the structure of water.
13 December 2006
Fluorescence spectroscopy combined with new diagnostic algorithms can be used to differentiate between early-stage benign and malignant skin lesions.
13 December 2006
A new technique for performing minimally invasive surgery inside the beating heart provides a visual representation of the surgical environment.
13 December 2006
Femtosecond excitation around 1μm offers prolonged, in vivo imaging of biological structures using nonlinear multimodal and fluorescence-lifetime imaging microscopy.
13 December 2006
Microscale approaches to depositing liquids on surfaces are suitable both for making biomolecule microarrays and as tools for rapid prototyping.
12 December 2006
Three-dimensional imaging and simultaneous time-lapsed tracking of many objects is now possible in environments such as the deep ocean.
12 December 2006
Both light scattering and fluorescence of membrane glycoproteins can be used to detect programmed cell death (apoptosis) quickly and cheaply.
29 November 2006
Direct laser ablation produces waveguides, micro-channels, and optical circuits in a single processing step, which could drastically reduce manufacturing costs.
29 November 2006
The latest featured patent review by analysts from Nerac examines new developments in laser eye surgery.
29 November 2006
A novel bioelectronic sensing device offers several potential advantages, including mechanical flexibility, and reduction in weight, power consumption, complexity, and fabrication cost.
20 November 2006
A new optical microscope that uses computed tomography and a novel transformation algorithm can provide pathological information about specimens, and distinguish healthy from cancerous tissues.
8 November 2006
Life scientists can capture the internal structure of samples with high resolution and minimal damage using adaptive-optics techniques borrowed from astronomy.
5 November 2006
Silicone materials and broadband optical interrogation dramatically improve the sensitivity of small interferometric fiber pressure sensors of relevance to biomedicine.
5 November 2006
Substrates for sensitive surface-enhanced Raman spectroscopy are made from nanorod arrays prepared by oblique angle deposition.
1 November 2006
A hierarchical detection algorithm quickly finds and isolates critical regions in low-quality imagery.
31 November 2006
The interference of two nonlinear optical signals generated in series can improve image quality in coherent anti-Stokes Raman scattering microscopy.
26 October 2006
Real-time detection of nanoparticles and cells, including cancer, is now possible in blood and lymph flow.
23 October 2006
Ultrashort laser pulses can be used to produce lesions in single blood vessels located in the cortex of live rats, thus enabling the study of microstrokes.
19 October 2006
A low-cost computer-aided system could screen for early signs of diabetic retinopathy, a treatable disease that is the leading cause of blindness in working-age adults in the industrialized world.
18 October 2006
Confocal microscopy in combination with higher-order laser modes can detect and distinguish individual metallic nanoparticles from a single scattering image.
16 October 2006
Activating drugs with light could be better used to fight disease by first simulating the optical properties of the light source and the body tissues being treated.
10 October 2006
Exposing polymers to UV could ease fabrication of cell-coated medical implants and cell micro-arrays for high-throughput screening.
9 October 2006
A freely available software platform can help researchers rapidly and safely prototype systems for surgical applications.
6 October 2006
Display characteristics vary with the kind of monitor under inspection and the method of testing.
4 October 2006
High-speed addressable optical elements enable fast recording of rapidly-changing cellular signals in light-scattering biological tissue.
25 September 2006
An integrated module based on nematic liquid crystal technology has an accuracy better than 1%.
19 September 2006
Florida State University is adapting educational websites it has built to cover the increasing application of optical microscopy in the biological and materials sciences.
13 September 2006
Radiologists can generate better reports by using interactive visualization tools, thereby improving physician efficiency and efficacy in diagnosing pathologies.
10 September 2006
Digital-holographic microscopy can measure the refractive index and thickness of human pancreatic tumor cells and can be used to analyze their morphology.
6 September 2006
A 3D optical imaging system may provide a fast and non-destructive technique to visualize and identify living specimens.
5 September 2006
A visual fixation monitor employs four spots of linearly polarized light impinging on different parts of the bow-tie pattern of polarization states reflected from the eye.
31 September 2006
A low-cost, safe, and easy-to-use imaging system lets a surgeon see surgical anatomy and invisible fluorescence: this both simultaneously and in real time.
17 August 2006
A dual-color fluorescent microscopy system captures the behavior, in real time, of cancer cells as they grow and spread in live mice.
16 August 2006
A combination of experiments and computational modeling show how ultrafast laser pulses are able to bore into glass without heat-related damage.
10 August 2006
Thermal energy intensities generated by surface-plasmon resonance can probe the behavior of molecular structures one flexible bio-molecule at a time.
9 August 2006
New diode-pumped solid-state lasers doped with thulium can be wavelength-tuned around the local water absorption peak at 1.94μm, making them attractive as versatile laser scalpels.
9 August 2006
A novel system using a 3D handheld navigation device allows users to explore volumetric imaging data.
1 August 2006
Ambient light and display luminance contribute significantly to diagnostic viewing conditions in the digital radiology reading room.
12 July 2006
A novel system for imaging electrical activity in the heart can aid in diagnosis, therapy, and development of new treatment strategies.
10 July 2006
New reagents and techniques in cell biology make it possible to visualize cell-signaling mechanisms in real time.
9 July 2006
Wireless tracking technology integrated with facial biometrics can improve security in health care facilities.
6 July 2006
The viewing angle of a 3D display based on integral imaging can be increased by adding a flat holographic array that acts as a virtual lens.
19 June 2006
In rooms for on-screen viewing of medical images, LCD monitors used with brighter ambient lighting can reduce eye strain without compromising image contrast.
19 June 2006
The dispersive properties of photonic crystals can be used to fabricate compact devices with a wide range of potential applications.
6 June 2006
Pulsed infrared laser light provides a new method for nerve stimulation with unmatched precision, and could soon be used in medical procedures.
25 May 2006
A new Raman system, consisting of optic fiber bundles coupled to an axial Raman spectrometer, shows potential for skin cancer detection.
15 May 2006
Detecting specific drug penetration in biotissue may be feasible in vivo without tissue destruction or conventional lab sample analysis.
5 May 2006
A hand-held scanning probe permits easy, rapid, real-time functional and morphologic imaging of cellular and subcellular structures inside living specimens.
1 May 2006
A real-time 3D laser-manipulation system can be used to assemble, organize, and actuate particles, microtools, and living cells.
1 May 2006
A prototype chemical device can perform micro-stirring, pH measurement and control, and even the sensing of single molecules.
1 May 2006
Nanochannels with diameters from 15nm to 100nm were fabricated and used to isolate the fluorescence signal from a single molecule.
27 April 2006
Recent developments in source and sensor technology are leading to new scientific and commercial applications for terahertz radiation.
27 April 2006
The liquid/solid interface provides an ideal environment to investigate self-assembly phenomena and to probe the structure and properties of monolayers at the nanoscale.
26 April 2006
Large, high-performance transducer arrays for medical diagnostics and therapeutic applications can now be realized using CMUTs
20 April 2006
Reconstruction and manipulation of amplitude and phase of the optical field in virtual numerical space generates unique microscopic images
20 April 2006
Electrically conducting plastics and nanoparticles aid simultaneous measurement of the activity of many genes.
19 April 2006
Laser-induced photothermal effects on individual living cells have both diagnostic and therapeutic applications.
17 April 2006
Splitting a model of the colon into two halves and having a virtual camera 'fly over' each one helps the physician detect colon polyps.
17 April 2006
The development of optical multiarray biochips is essential for the immediate rapid screening of patients.
17 April 2006
A new platform of photoluminescent sensors excited by an array of OLED pixels is being developed for a broad range of medical, environmental, and industrial applications.
2 April 2006
Developing low-cost broadband semiconductor IR sources that could enhance the performance and resolution of OCT systems.
1 April 2006
A technique that allows soft x-rays to be focused using reflective elements that mimic a lobster's eye is extended to hard x-rays.
21 March 2006
A new approach based on multi-element source-detector arrays enhances the spatial resolution and depth-discrimination capability of diffuse optical imaging.
13 March 2006
Field-programmable gate arrays (FPGAs) can implement high-performance coprocessors that accelerate volumetric pattern matching by 100-1000 times as compared to PCs.
6 March 2006
A fiber-based femtosecond laser takes advantage of photonic-crystal fiber technology to extend the tuning range to more than 200nm, making it a potential source for biomedical imaging.
3 March 2006
By applying near-infrared en-face OCT to paintings, we can examine the optical properties of the varnish and paint layers, drying processes, and the underdrawings.
7 February 2006

A practical upgrade path from conventional film-screen to digital mammography uses tiled complementary CMOS imagers.

7 February 2006

An array of laser diodes and semiconductor amplifiers should be able to physically model the operation of the brain.

7 February 2006

Laser Doppler imaging (LDI), used for measuring in-vivo blood flow in biological tissues such as skin or brain tissue, has dramatically improved by exploiting high-speed CMOS image sensor technology.

7 February 2006
A new microchip analyzes thousands of cells per minute in an enclosed microfluidic environment.
7 February 2006
New fiber-optic sensor systems enable non-destructive plant biotechnology monitoring.
1 February 2006
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From OE Reports Number 186 - June 1999
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From OE Reports Number 159 - March 1997
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From OE Reports Number 157 - January 1997
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