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All Technical Articles - Biomedical Optics & Medical Imaging

All Newsroom Technical Articles, starting with the most recently posted:

The recent development of Brillouin microscopy enables the longitudinal moduli of cells to be mapped in high 3D spatial resolution, without the need for contact or a labeling agent.
22 March 2017
Surface-enhanced Raman scattering can be used as an alternative approach for evaluating the toxicity of nanoparticles in single living cells, bypassing the complications faced by conventional cytotoxicity assays.
13 March 2017
Complementary kernel matching greatly increases the depth of field for time-resolved 3D ranging and snapshot imaging, and shows promise for applications ranging from biomedical microscopy to machine vision.
7 March 2017
An oligonucleotide sequence conjugated to a fluorophore–quencher pair, and then loaded in polymethyl methacrylate nanoparticles, can be used as a theranostic agent.
24 February 2017
A novel spectroscopic method adds functionality for high-spatial-resolution and high-accuracy detection of lipid-rich plaques.
20 February 2017
Photonics West_thumb

From the SPIE Photonics West Show Daily:The first-ever neurophotonics plenary session at Photonics West featured 10 rapid-fire presentations covering the broad spectrum of current neurophotonics R&D.

16 February 2017
Photonics West_thumb

From the SPIE Photonics West Show Daily: Advances in microscopy dominated the BiOS Hot Topics presentations at Photonics West, detailing advances in new techniques that could dramatically influence molecular research, drug development, and clinical diagnostics.

15 February 2017
A suite of flexible and biocompatible threads, embedded with sensors and electronics, can be sutured/woven into tissue for in situ measurements of physical and chemical biomarkers.
13 February 2017
An innovative full-field optical technique can be used to measure deformation of ocular tissue with nanometric accuracy.
8 February 2017
A prototype endoscopic imaging system, based on flexible terahertz waveguide technology, detects tissue abnormalities in real time and may ultimately enhance in vivo cancer screening.
1 February 2017
High-resolution ex vivo imaging of the brain is achieved with a novel technique that will enable studies of normal brain structure and the effects of neurological disorders.
27 January 2017
The journey of a single molecule can be followed with nanometer spatial precision and microsecond temporal resolution by using interferometric scattering optical microscopy and an ultrahigh-speed camera.
25 January 2017
A novel super-resolution approach involves nonlinear scattering from plasmonic nanostructures, including saturation and all-optical switching.
10 January 2017
Stimulated Raman scattering is used together with a novel, small-alkyne-tagged glucose analogue to visualize glucose uptake activity at the single-cell level.
30 December 2016
Recent advances in laser technology enable a betatron hard x-ray source, with which ultrahigh resolution and fast biomedical imaging may be realized.
26 December 2016
Plasmonic oscillations on graphene and 2D biocompatible nanomaterials are combined to yield ultrasensitive devices suitable for clinical diagnostics and early treatment of disease.
9 December 2016
Diffuse correlation spectroscopy and time-resolved near-IR spectroscopy are used in the BabyLux tool to monitor cerebral oxygenation and hemodynamics.
6 December 2016
Quantitative phase-digital holographic microscopy offers high-throughput label-free detection capabilities for identifying cellular biomarkers of mental disorders.
1 December 2016
In the Active Learning in Optics and Photonics program teachers are taught inquiry-based strategies, and low-cost optics technologies are brought to the classroom.
21 November 2016
An amorphous compound, composed of molecular clusters with high optical nonlinearity, enables the generation of continuous-wave white light with the use of a low-cost IR laser diode as the pump source.
18 November 2016
Transfer printing microstructures onto novel hydrogel interfaces and customised composite electrodes could increase the compatibility and information transfer between body tissue and electronic devices.
15 November 2016
A new and versatile method for integrating light-emitting nanoparticles, without loss of their unique properties, into glass is demonstrated.
8 November 2016
A terahertz laser, combined with an uncooled microbolometer camera, is used in a digital holography method to provide improved resolution of skin profiles.
7 November 2016
Stable spatially and spectrally differentiated laser beams can be delivered to remote locations and may thus enable endoscopic in vivo imaging, with resolution beyond the diffraction limit.
4 November 2016
Metallic magnetoplasmonic nanostructures are used for the transducer layers in novel probes to achieve enhanced sensitivity.
24 October 2016
Small laser spots can have a negative impact on the accuracy and precision of measurements when used in surface-enhanced Raman scattering for quantitative characterization.
14 October 2016

A decade's worth of advances in five years is the goal of the photonics community and partners, working on imaging, diagnostics and data management.

23 September 2016
Fundamental and robust pre-processing of cranial computed tomography exams enables algorithms for automatic analysis and interpretation of diagnostic images in acute stroke.
22 September 2016
Two novel approaches enable imaging of cells over large fields of view, with high spatiotemporal resolution.
16 September 2016
Light–matter interactions are strongly coupled in the liquid cores of novel optofluidic devices that are suitable for integration in compact and highly sensitive optical sensors.
14 September 2016
A profiled laser allows for dynamic Raman imaging of living cell structure and functions, and alkyne tags improve the Raman signal with minimal physiological perturbation.
7 September 2016
A photothermal nanoblade couples a metal-tip-coated, wide-bore micropipette and a pulsed laser to induce a microscopic ‘explosion’ that cuts cell membranes, enabling the delivery of mitochondria.
1 September 2016
A holographic optical trapping technique enables 3D manipulation of cytoskeletal filaments, such as for building complex networks that capture key features of biological cell structures.
26 August 2016
An assay based on silver nanoparticles of different colors provides rapid diagnosis for multiple diseases.
24 August 2016
Deconvolving resting-state brain activity from hemodynamic effects reveals a set of spatially and temporally overlapping networks, providing new insights into brain function in health and disease.
15 August 2016
Preliminary results from a single-trial rapid serial visual representation task demonstrate the potential for enabling generalized human-autonomy sensor fusion across multiple subjects.
13 August 2016
A new system enables multiparametric scans for investigating rodent models of diseases and cross-validation studies of bimodal imaging probes.
12 August 2016
A novel strategy is used to synthesize porous gold-silver alloy nanospheres encased in ultrathin silica shells that can act as highly sensitive single-particle probes.
4 August 2016
High-resolution transmission electron microscopy is combined with a novel preparation method, based on superhydrophobic sample control, to achieve a spatial resolution of down to 1.5Å.
3 August 2016
Accurate mechanical measurement of stiffness in individual breast tumor cells provides information that can assist with disease prognosis.
1 August 2016
A novel annihilating filter-based low-rank Hankel matrix approach can be combined with classical analytic reconstruction techniques for application to several compressed sensing imaging problems.
27 July 2016
Silver nanoparticles are used in two different strategies to achieve high sensitivity to parasites and thus facilitate early malaria diagnosis.
27 July 2016
Fully fiber-integrated femtosecond laser systems covering the visible spectrum could take advanced biomedical imaging techniques from the laboratory to real-world applications.
23 July 2016
A cost-effective, freeform method of manufacturing epidermal electronic systems enables long-term, high-fidelity physiological signal monitoring.
21 July 2016
Phase-sensitive imaging and computational correction of patient-specific optical aberrations enable high-resolution imaging of the human retina to aid diagnosis and treatment of eye diseases.
20 July 2016
High-performance detectors that are compatible with mainstream semiconductor device fabrication deliver high speed, ultra-sensitivity, and good timing resolution.
15 July 2016
Combining tightly focused laser beams with surface-treated microtools enables injection and surface biopsies on individual live cells, with minimal disruption to their normal function.
13 July 2016
Tunable light sources and megapixel detectors can improve mid-IR spectral imaging for large-scale histopathological assessment of biological tissues, enabling rapid medical diagnosis.
5 July 2016
A novel project, known as the Pathology Operating System, is being tested and implemented in Sweden for the digitalization of pathology services.
2 July 2016

A graphene-based electronic patch monitors glucose in sweat noninvasively and provides feedback-controlled drug delivery by using microneedles with a heat-responsive coating.

29 June 2016
A photoactivated technique targets tumor cells and simultaneously triggers the release of inhibitors at ‘ the right time and place’ to block the mechanisms that enable some cancers to escape treatment.
24 June 2016

Wearable devices are rapidly advancing in terms of technology, functionality and size, with more real-time applications. The disruption has already begun in health monitoring.

21 June 2016
Image formation based on computation and aberrated optical design provides a promising approach for volumetric imaging studies of biological dynamics at cellular and sub-cellular resolution.
20 June 2016
A new approach enables glucose detection over a spectral range that offers superior depth penetration in tissue, and thus presents possibilities for non-invasive blood sugar monitoring.
15 June 2016
Near-IR light at wavelengths of 1600–1870nm offers the best transmittance for deep brain imaging.
8 June 2016
A comparison of imaging using deuterium oxide and water immersion media shows that deuterium oxide significantly enhances signals for image contrast in the 1700nm excitation window.
1 June 2016
Finite element technology and practical insights can enhance the accuracy of magnetic resonance-guided ultrasound biopsy of the prostate.
27 May 2016
Lanthanum fluoride particles passively collect in tumors and amplify applied radiation doses, while also transferring energy to photosensitizer dyes that enable the targeting of cancerous cells.
20 May 2016
The integration of a time-variable array of pinholes can be used to perform high-resolution imaging with high energy efficiency, and significantly extend the field of view when combined with an imaging lens.
16 May 2016
A digital holographic microscope operating in telecentric mode could be used to diagnose diabetes and evaluate long-term glycemic control in patients with diabetes.
9 May 2016
A hexagonally patterned hyperlens array enables high-throughput super-resolution imaging of living cells, without the need for complex optical systems.
4 May 2016
Quantum dots exhibit a measurable rapid photoluminescence response to neuron-like electric fields and can thus be used to observe neuronal action potentials.
27 April 2016
The butterfly proboscis is a unique, naturally engineered device for acquiring liquid food, and may inspire novel developments in micro- and nanofluidic engineering.
21 April 2016
Applying optical imaging to cellular mechanisms one cell at a time could improve disease detection and diagnosis.
19 April 2016
Combining stimulated-emission-depletion microscopy with fluorescence-correlation spectroscopy enables the simultaneous confocal and super-resolution monitoring of molecular diffusion.
9 April 2016
A new microfluidics-based 3D tissue culture method facilitates rapid and simultaneous viability measurements on multiple samples, offering the possibility of patient-specific assays.
28 March 2016
A tiny, low-cost evanescent-field biosensor chip with a directly integrated optical detector enables carcinogenic contaminant detection and shows promise for point-of-use application.
21 March 2016
Analyzing the optical properties of plant cells forms the basis for an adaptive optics microscope that obtains near-diffraction-limited images.
9 March 2016
Incorporating adaptive optics, such as a deformable mirror, in super-resolution microscopy enables imaging of structures at depths of 15μm.
2 March 2016
The DNA nucleobase guanine can maintain graphene's electrical properties, and may have potential applications in flexible, graphene-based sensors for use on the body.
18 February 2016
Detecting proteins and nanobioparticles using microarray technologies enables resolution and sensitivity beyond the reach of ensemble measurements.
18 February 2016
A multimodal optical imaging approach enables assessment of the long-term reliability of microelectrodes used to record brain activity, stimulate specific cortical regions, and control neural prostheses.
16 February 2016
A handheld fiber probe with adjustable offsets enables spatially offset Raman spectroscopy at different depths for noninvasive analysis of callus composition during fracture healing.
15 February 2016
DNA electronic devices can distinguish various forms of DNA damage and are now being used to follow anticancer drug activity.
6 February 2016
Integration of planar nanophotonics and microfluidics offers a new route for high-throughput sorting of bacterial cells in real time.
28 January 2016
Long-range surface plasmon polariton waveguides are used in a novel sensor for the detection of kappa and lambda light chain immunoglobulin relative concentrations.
22 January 2016
Non-invasive imaging through scattering media is achieved with the use of patterned illumination and single-pixel photodetection.
18 January 2016
Errors in the detection of phase changes by optical coherence tomography can be reduced significantly by using volumetric recording of images and digital image-processing techniques.
13 January 2016
Bridging the gap between electronics and biology, bioprotonic devices control protonic currents (H+), which may affect physiological function.
11 January 2016
The photorefraction of IR light and astigmatism from a cylindrical lens are used to assess variations in the human eye as a function of perceived depth information.
8 January 2016
Focus shaping using vortex laser beams improves precision in corneal surgery by facilitating cleavage along the lamellae in the cornea, and enables cutting with reduced absorbed pulse energy.
7 January 2016

Advanced algorithms that leverage computer vision and signal processing concepts are used to estimate vital signs from small changes in skin color.

30 December 2015

Quantitative image information combined with personal risk factors can provide breast screening that is better tailored to the individual.

28 December 2015

A technique that distinguishes single from multiple scattered waves achieves microscopic imaging with a near-diffraction-limit resolution of 1.5μm, at depths that would benefit medical applications.

22 December 2015

Microlasers can be embedded inside single mammalian cells, enabling the tagging of a large number of cells and very sensitive real-time sensing of the forces and refractive indices within cells.

21 December 2015
An integrated fluorescence spectroscopy approach can be used to examine the diffusion of molecular probes, protein folding processes, and several biochemical reactions.
11 December 2015
A technique combining Raman and Fourier transform IR spectroscopies enables simultaneous topographical and chemical imaging at high resolution.
4 December 2015
Biomedical imaging for preclinical applications is rapidly advancing and benefiting from the introduction of powerful new computing hardware.
3 December 2015
Imaging techniques based on autofluorescence and reflectance offer objective diagnosis of middle-ear pathological conditions.
30 November 2015
Nanoformulated compound derivatives naphthalocyanines enable dual-color photoacoustic demarking of lymph node networks.
20 November 2015
Multifunctional fibers enable simultaneous recording, optical stimulation, and drug delivery into the nervous system.
16 November 2015
A combination of optics coding and digital processing enhances the capabilities of traditional light microscopes, enabling acquisition of information such as phase, which cannot otherwise be captured.
4 November 2015
Supported membranes typically used in bionanotechnological devices have a higher degree of order than free membranes and show lipid clustering, which could affect device functioning.
3 November 2015
A three-camera microscope without moving parts enables fast and accurate tracking of individual enzyme molecules, their regulators, and catalytic product molecules simultaneously in the nuclei of living cells.
2 November 2015
A monolithic optofluidic chip fabricated by femtosecond laser extracts highly metastatic cells from a heterogeneous population on the basis of optical stretching measurements.
27 October 2015
Electrochemical transistors based on organic polymers enable a potentiometric sensing platform for flexible, versatile, and disposable biosensors.
22 October 2015
Compensating for modal scrambling during illumination and detection enables the use of multimode fibers to transmit high-contrast, confocal images for endoscopic applications.
16 October 2015
A new tactile sensing device that simultaneously detects thermal and mechanical stimuli could find use in artificial skin systems.
14 October 2015
Automatic analysis of x-ray images enables on-site screening for tuberculosis infection, addressing the shortage of trained radiologists in rural Kenya.
8 October 2015
A new USB-powered lightweight device was developed to improve early detection of glaucoma and other eye diseases.
28 September 2015
Combined spatial frequency domain imaging enables improved monitoring of hypertrophic scar formation, making interventional procedures more effective.
24 September 2015
Holographic control of light traveling through multimode optical fibers enables minimally invasive imaging deep inside sensitive living tissues.
23 September 2015
Focused ultrasound combined with sensitizing agents used in photodynamic therapy increases the ability of anti-cancer drugs to inhibit tumor growth.
12 September 2015
Upconverting nanoparticles are coupled with gold nanorods to achieve increased emission brightness, enhanced diagnostic strength, and improved determination of local temperature.
25 August 2015
A holographic optical-tweezers-based approach allows the fabrication of bacterial microsystems, such as fluid mixers or micro- and nanotransport vehicles for functional particles.
20 August 2015
Smart design of optofluidic labs-on-chips offers the sensitivity of laboratory-scale optical detection instruments with portability, fast response times, low sample consumption, and parallel processing and read-out.
12 August 2015
MRI sparse sampling and constrained reconstruction techniques enable high-resolution images of the entire brain with no increase in scan time or apparent loss of diagnostic information.
3 August 2015
The Tikhonov L-curve can be used to determine optimum regularization parameter values for the generalized autocalibrating partially parallel acquisitions approach.
24 July 2015
Smartphones combined with advanced image processing algorithms offer an accessible tool for diagnosis and monitoring of medical conditions.
13 July 2015

Quantitative analysis of contrast-enhanced ultrasound enables fast, 97% accurate diagnosis and assessment of rheumatoid arthritis for personalized therapy.

6 July 2015
Accurate volumetric ultrasound images are generated by combining 2D images with real-time information on the position of transducers.
30 June 2015
The intrinsic fluorescence of single-walled carbon nanotubes in the NIR-IIa window enables high-resolution (sub-10μm) vascular images at ∼3mm depth in a live mouse brain, through intact scalp and skull.
22 June 2015
Imaging blood flow in diabetic leg and foot ulcers with near-IR light offers a non-contact method of differentiating healing from non-healing wounds.
17 June 2015
New fiber sensors are structured by laser writing and chemical etching to interconnect optical circuits with the core waveguide and probe integrated sensors embedded within the surrounding fiber cladding.
8 June 2015
Sparse sampling and constrained reconstruction enable 83-frames/second real-time magnetic resonance imaging, providing new insights into the dynamics of vocal-tract shaping.
3 June 2015
A nanohole optical tweezer technique probes the vibrations of individual nanoparticles, such as proteins, DNA fragments, colloids, and viruses.
29 May 2015
A fully integrated, customizable, and mass-producible microscope-on-chip uses integrated photonics to implement its compact and high-quality coherent illumination subsystem.
26 May 2015
Raman spectroscopy distinguishes cancer tissue from normal brain in real time with over 90% accuracy during brain tumor resection.
22 May 2015
Electrolyte-gated field-effect transistors enable reliable and highly sensitive biosensors on flexible and disposable substrates, ideal for next-generation point-of-care devices.
18 May 2015
Blue LED light can selectively inactivate microbes while preserving host cells, offering a promising therapy for drug-resistant infections.
15 May 2015
Capillaries filled with brightly fluorescent quantum dots act as durable, inexpensive microfluidic biosensors.
11 May 2015
A novel reader platform with imaging-based analysis improves the sensitivity of immunoassay tests used for diagnostics outside the laboratory.
8 May 2015
A novel, compact optical sensing and imaging platform can be used for affordable next-generation, smartphone-based personal and point-of-care applications.
1 May 2015
High-index microspheres embedded in elastomer or immersed in liquid allow straightforward super-resolution imaging of biological, metallic, and semiconductor structures.
29 April 2015

Experiments in an animal model of multiple sclerosis demonstrate the therapeutic potential of 670nm light treatment.

24 April 2015
Novel stimuli with imperceptible flickers can be used for next-generation brain–computer interfaces and for biomedical applications.
22 April 2015
Combining a new computational optical imaging method with a streak camera enables 2D ultrafast photography of nonrepetitive events at 100 billion frames per second.
21 April 2015
A new lens-free on-chip microscope, which adopts a synthetic aperture approach, achieves a half-pitch resolution of 250nm with an effective numerical aperture of ∼1.4 and a wide field of view (over 20mm2).
13 April 2015
Methods for measuring the mechanics of surface-attached bacterial systems on a range of lengthscales enables enhanced understanding of their disease-causing properties.
9 April 2015
Surface-enhanced Raman scattering captures spectral information from living cells, improving our understanding of a cell's molecular status.
6 April 2015
Magnetoelastic biosensors detect food-borne pathogens on-site, directly, and in real time.
3 April 2015
Laser-induced transfer technology can print very small and delicate objects for applications in nanophotonics and tissue engineering.
30 March 2015
Femtosecond laser microfabrication enables rapid prototyping and development of novel microfluidic platforms with biological applications.
27 March 2015
A wearable ultrasound therapy device, operating at 20kHz and monitored by concurrent optical diffuse spectroscopy, is associated with faster healing of chronic venous ulcers.
16 March 2015
Image from The Rapid Imaging Renaissance plenary talk by Daniel Sodickson at SPIE MEdical Imaging 2015

Rapid advances in imaging, sensing, and their underlying mathematics highlighted this important annual gathering to explore new medical advancements.

16 March 2015
A method using targeted fluorescent probes in cerebrospinal fluid could detect Alzheimer's disease several years earlier than current exams.
4 March 2015
Novel, low-complexity computation methods enable reconstruction of high spatial resolution images for combined ultrasound-photoacoustic computed tomography.
23 February 2015
Multiphoton excited photochemistry creates nano/microscale models that duplicate the ovaries' native structure and composition for better cancer diagnosis and therapy.
17 February 2015

A new method from the lab of Nobel laureate W. E. Moerner enables the direct visualization of the binding and unbinding interactions between single biomolecules in aqueous solution by observing the diffusion coefficient and electrokinetic mobility.

17 February 2015
Methods such as digital photoelasticity and digital moiré interfero metry can be customized to examine and characterize the response of dental hard tissue to mechanical and thermal forces.
10 February 2015
A new spatial-spectral technique based on volume holographic methods can be used to acquire resolved images from multiple depths simultaneously.
4 February 2015
Electronic contact lenses can switch between different focal powers, functioning similarly to putting on and taking off reading glasses.
19 January 2015
Investigating signal processing in neurons that connect the retina to the visual cortex enhances our understanding of how neurons function within a network.
7 January 2015
A method that uses lasers to position bacteria with single-cell precision shows that even small groups of a few microbes can increase their own growth rate and impair the development of other infecting species.
30 December 2014
A label-free optical biosensing platform, capable of monitoring single DNA molecules and their interaction kinetics, achieves unprecedented sensitivity in the optical domain.
22 December 2014

Engineering light-sensitive receptors yields variants that can inhibit and sense neuronal activity, expanding the toolbox of genetically encoded voltage sensors for use in optogenetics.

9 December 2014

Success stories from teachers show that STEM curriculum using the scanning electron microscope excites their students and improves academic performance.

3 December 2014

A quantitative fluorescence imaging system identifies brain tumors by collecting hyperspectral data under selected illumination, adjusting for tissue attenuation effects, and identifying tumor biomarkers.

26 November 2014

Using multiplexing and an LED array to code illumination angles in a commercial microscope achieves fast capture times, resolution beyond the diffraction limit, and a very large field of view.

17 November 2014

Using a novel adaptive non-local-means denoising method permits radiation doses from any computed tomography scanner to be reduced by 50% without affecting diagnostic performance.

12 November 2014

Membrane-wrapped gold nanoparticles designed to have specific surface properties have been used to investigate and mimic complex viral processes.

4 November 2014
Disposable free-form plastic prisms and common-path phase interrogation cut development costs.
23 October 2014
Fluorescent intracellular co-enzymes act as natural in vivo biomarkers for environment- and disease-induced changes in energy metabolism and biochemical reactions.
10 October 2014

A novel imaging and tissue analysis scheme in the terahertz frequency band has the benefits of simplicity, coherence, and high sensitivity.

2 October 2014

Ordered lattices of nanostructures with unique electromagnetic properties not found in nature offer novel sensing possibilities for diagnosis, treatment, and management of disease.

30 September 2014
Harnessing the strong electro-optic properties of liquid crystals permits high-resolution, extended depth of focus, and multi-parameter imaging.
5 September 2014
Exposure to laser light stimulates dental stem cells to form new mineralized tooth tissue and points the way to novel applications of laser stem cell therapy.
11 August 2014
Adaptive confocal laser scanning microscopy and laser interferometry systems have several applications in the fields of biomedicine and fluid mechanics.
7 August 2014
Airy light fields, with their unique transversal structures, offer new possibilities for 3D imaging by light sheet microscopy.
18 July 2014
A new label-free 3D imaging method using a commercial microscope and a quantitative phase imaging module reveals cellular structures of live cells with submicron resolution.
11 July 2014
A novel configuration of a near-IR-sensitive camera and adaptive optics for fast imaging of singlet oxygen luminescence in vivo predicts the effectiveness of light-based therapies.
3 July 2014

A new approach has achieved quantum-enhanced contrast and resolution in biological microscopy, opening the possibility of subcellular imaging with unprecedented resolution.

26 June 2014
Phase-sensitive optical coherence tomography measures the morphology and functional vibratory response in the mouse cochlea and helps decipher the complex mechanical processes responsible for hearing.
23 June 2014
Autofluorescence and diffuse reflectance spectroscopy identify malignant melanoma with 93% accuracy.
19 June 2014
Understanding a variety of biochemical features and biological processes might enable the design of plasmonic particles that home in on tumors for imaging and therapy.
13 June 2014
A novel imaging spectrometer enables the incorporation of captured 2D images with high-resolution spectral and temporal data for the analysis of transient events.
10 June 2014
A noninvasive, portable, smartphone-based EEG system for at-home measures of cognitive function promises rapid transmittal of data and reduced clinic visits for patients.
28 May 2014
Wearable wireless sensors and nonlinear dynamics identify postural characteristics relevant to balance control and dynamic stability, revealing predictive risk of falls among older adults.
28 May 2014
A new nano-optical tweezer enables capture and analysis of individual proteins, as well as single-protein interactions with small-molecule drugs and with DNA.
22 May 2014
A handheld mid-IR laser imaging platform detects trace materials quickly and with high sensitivity for explosives detection and medical diagnosis.
20 May 2014
The use of 16-bit imaging for evaluating dermatologic conditions in remote populations is as reliable as using 32-bit in-hospital imaging.
16 May 2014
A plano-convex electrode for a hexagonal LC lens array combines a small inactive region, 30μm cell gap, short focal length, and operates at low applied voltage.
9 May 2014

A special session at SPIE Photonics West celebrated the 45th anniversary of the supercontinuum. Audio and slides from the presentations are available.

29 April 2014
Two new optical probes provide high-contrast, high-resolution images of tumors and their inflammatory microenvironment by early targeting of the translocator protein and late trapping within activated macrophages.
16 April 2014
Combining three laser beams, including a doughnut-shaped beam, permits ‘super-resolution’ microscopy of nanostructures with the contrast of optical absorption.
7 April 2014
A novel sensor system simultaneously analyzes several biochemical signals to produce a rapid YES/NO output, with particular applications for field medical care and homeland security.
26 March 2014
Near-IR lasers acting on polymer biospheres can selectively perforate cell membranes or release molecules for targeted delivery of medication.
21 March 2014
Microspheres of rare-earth-doped chalcogenide glass coupled to mid-IR amplifiers and lasers of tapered fibers may serve as efficient biomedical sensing devices.
18 March 2014

Strain-induced polarization charges in piezoelectric semiconductors modulate the electronic and optoelectronic processes of charge carriers at the interface, opening up novel applications.

17 March 2014
Crystalline nanostructures in coal

A fast, simple solution-based method extracts photoluminescent carbon dots from coal with up to 25% yield.

14 March 2014
Directing prism serration outward rather than eyeward results in wide field expansion and fewer spurious reflections for patients.
11 March 2014
Using a Fourier-based phase correlation method and progressively coalescing strongly connected components permits terabytes of optical microscopy data to be assembled correctly more rapidly than previously.
10 March 2014
A proposed design for an automated system using wireless biodetectors continuously monitors astronauts' metabolic levels, heart and respiration rates, and other markers of health in deep space.
27 February 2014
Destructive interference greatly improves the signal-to-noise ratio of fluorescence detection based on stimulated emission.
25 February 2014
Photoacoustic tomography offering a large field of view and high spatial resolution enables, for the first time, noninvasive imaging of resting-state functional connectivity in the murine brain.
21 February 2014
Low-frequency (5Hz) optical activation of dopamine neurons significantly delays the first drink and reduces a drinking binge by 54%.
19 February 2014
Diode lasers simultaneously offer tunability, high-power emission, and compact size at fairly low cost and are increasingly preferred for pumping titanium:sapphire lasers.
6 February 2014
Optical coherence tomography in live animal models offers dynamic imaging capabilities for analyzing how aberrant morphologies and other birth defects occur during embryogenesis.
28 January 2014
Liquid droplets are flexible and easy to produce, making them attractive as tunable light sources for a range of biologically relevant applications.
17 January 2014
A novel deep imaging approach applies a transmission matrix formalism to photoacoustic techniques to better guide light and enhance signals.
9 January 2014
Infrared and Raman spectroscopic systems automatically discriminate tissues, demarcate cancerous areas, and detect characteristic marker patterns in the spectra of body fluids.
7 January 2014
A novel laser-terahertz emission microscope is used to visualize changes in chemical and electrical potential.
31 December 2013
Dual-wavelength laser pulses on red blood cells create a photoacoustic effect that enables high-resolution study of in vivo cellular oxygen consumption in normal and diseased tissues.
16 December 2013
Combining laser light and an indocyanine-green-infused chitosan patch repairs and joins small blood vessels end-to-end.
10 December 2013
A biophotonics technique based on autofluorescence imaging and Raman scattering can diagnose skin tumors during surgery faster than conventional histopathology, without tissue sectioning or staining.
26 November 2013
Computer-aided analysis and diagnostics based on medical imaging may enable identification of specific tumor signatures.
14 October 2013
Using a multimode fiber for scanning fluorescence imaging may help visualize inside small cavities.
10 October 2013
Enhancements to the whispering-gallery-mode plasmonic biosensor enable a high level of sensitivity in detecting nanoscopic protein particles, with application to the early treatment of disease.
30 September 2013
Techniques for laser ultrasonic inspection of industrial materials enable researchers to acquire sensitive, safe, and non-contact photoacoustic and ultrasound images of biological tissues.
26 September 2013
A technique based on highly undersampled radial MRI yields data with excellent spatiotemporal resolution for quantitative parameter mapping without increasing scan time.
23 September 2013
A device using light pipes and thin film coatings homogenizes LED light of different wavelengths, offering advantages over bulb technologies.
9 September 2013
Advances in microfabrication have led to the development of silicon-based chips capable of ultra-sensitive flow measurements of clinical bioparticles.
3 September 2013
Multilayered graphene petal nanosheets enhanced with platinum nanoparticles and enzyme glucose oxidase can monitor the wide range of glucose concentrations found in saliva, tears, blood, and urine.
3 September 2013
A novel technique uses ultrasonic encoding and time reversal to break the diffusion limit and enable optical imaging, manipulation, and therapy at greater depths.
28 August 2013
A lensless optical configuration comprising laser and camera provides an ‘instant snapshot’ of the contraction statistics of muscle cells in an illuminated culture.
14 August 2013
A method of detecting suboptimal microscopy settings explores the relationship between instrument settings, image quality descriptors, and the accuracy of image post-processing.
6 August 2013
Integrating eye-tracking technology can improve the clinical utility of computer-assisted detection technology by matching decision support to the individual radiologist.
1 August 2013
A decision support system is being designed to help breast cancer patients choose reconstruction options that meet their quality-of-life concerns.
25 July 2013
A high-resolution interferometric imaging technique could enable intraoperative diagnosis, reducing the need for multiple biopsies and operations in cancer treatment.
12 July 2013
Mesoporous silicon nanomaterials can be fabricated and biofunctionalized for in vitro and in vivo controlled drug delivery and theranostic applications.
1 July 2013
A better way of characterizing light could enable innovative applications in areas such as biological diagnostics and remote sensing.
27 June 2013
Imaging technique estimates the location of individual particles with nearly the same accuracy that is achievable only in the absence of detector noise and pixelation.
24 June 2013
Encoding the position of image speckles enables optical resolution imaging in media that scatter light.
19 June 2013
A formalism based on performance of detection and estimation tasks enables the quantification of the information content of each imaged photon.
12 June 2013
Researchers may be able to better guide radiation therapy, analyze atherosclerotic plaques, and assess acute strokes and brain injuries using simultaneously captured multi-modal images.
11 June 2013
Human retinal pigmented epithelium cells in culture are more resistant to a lethal pulse of laser radiation if they are first exposed to low levels of red light.
10 June 2013
Technology that can image the surgical field at different levels of magnification may increase the ease and safety of laparoscopic surgery.
4 June 2013
By analyzing the content of electrical activity at the surface of the brain, researchers can distinguish between patients who are healthy and those with different types of cognitive impairment.
3 June 2013
A laser-triggered cavitation bubble shaped by a metallic nanostructure cuts a transient, micron-sized pore in the membrane of a living cell for large cargo delivery.
29 May 2013
Extending Deep Zoom technology allows the viewer to record a customized path through many image files, enabling further measurements.
24 May 2013
Piezoelectric nanoribbons permit the electrical recording of cell's mechanical responses to electrical stimulation.
17 May 2013
Improved 3D computed tomography produces clearer images and improved clinical diagnoses of breast cancer while dramatically reducing patients' exposure to radiation.
17 May 2013
A tethered capsule that is swallowed by the patient offers a quick and pain-free method of screening and diagnosing gastrointestinal diseases.
7 May 2013
Phase imaging methods based on white light illumination can reduce costs for medical blood testing and screening.
25 April 2013
Cerenkov optical imaging combined with whole-body positron emission tomography provides guidance for surgical planning and intervention.
19 April 2013
Pathologists reading digital slides may need higher-resolution displays to achieve consistently accurate diagnoses.
28 March 2013
Photoacoustic ophthalmoscopy provides exceptional contrast when visualizing the retina, assisting in the early diagnosis of some eye diseases.
19 March 2013
Incorporating superconducting and semiconducting elements into electromagnetic metamaterials can achieve active control of terahertz radiation.
18 March 2013
Optical coherence tomography combined with a focused air-puff system non-invasively assesses the mechanical properties of soft tissues and can be used to differentiate tumors during surgical treatment.
15 March 2013
Exposing cells to nanosecond pulsed electric fields causes a rapid increase in intracellular calcium, enabling a pathway that activates protein kinase C for various physiological functions.
4 March 2013
An emerging tool in life sciences, quantitative biological imaging, and nanobiotechnology, interference microscopy provides opportunities to study the biophysical properties of living cells as never before.
28 February 2013
Structural biologists use the ultra-intense pulses from x-ray lasers to overcome the problem of radiation damage in crystallography, removing the need for large, well-diffracting crystals.
21 February 2013
Tracking the bending movement of an atomic force microscope cantilever arm helps quantify the local impulsive force required to shift one cell relative to another.
19 February 2013
A high-resolution fluorescence microscope couples with the iPhone camera to analyze biological fluids where they are collected, saving time and money.
13 February 2013
Various blood biomarkers were screened for their ability to monitor nanoparticle neurotoxicity by analyzing bound proteins on their surface.
12 February 2013
Classification-image methodology reveals the mechanisms of observer performance in biomedical applications to enhance diagnosis.
8 February 2013
The ability to measure and manipulate aberrations in the human eye using adaptive optics will allow visual testing tailored to a patient's specific correction needs.
5 February 2013
Conditions that lead to vision loss can be diagnosed outside the clinic using a portable, pen-sized camera that is simple to align and operate.
25 January 2013
Photothermal heating helps image contrast agents at scarce concentrations over a scattering tissue background.
15 January 2013
A novel, low-cost, and miniature imaging system aids surgeons in identifying tumors for excision.
15 January 2013
Probing the micro-mechanical properties of tissue using optical imaging might offer new surgical tools that enable improved differentiation of tissue pathologies, such as cancer or atherosclerosis.
11 January 2013
A novel system measures the structure, shape, and acoustically induced changes to the membrane of the human middle ear, to help diagnose and treat hearing disorders.
9 January 2013
Using a single light source to carry out optical coherence tomography and photoacoustic microscopy simultaneously enables novel studies of optical scattering and absorption in biological tissues.
3 January 2013
Photoirradiation controls the release of molecules in the body that may inhibit tumor growth so therapy can be targeted to specific sites.
28 December 2012
A single intracoronary optical device yields concurrent and combined microstructural and fluorescence information from luminal samples, such as arterial tissue.
18 December 2012
High-resolution images in deep tissue are obtained using photoacoustic images of Förster resonance energy transfer, overcoming the problem of light-scattering effects in some imaging techniques.
12 December 2012
Using liquid crystal devices to convert Gaussian beams to vector beams dramatically improves confocal and multi-photon laser microscopy in living tissues.
10 December 2012
Wearable skin sensors can monitor body signals with high sensitivity and wide dynamic range, enabling in vitro diagnostics and the use of therapeutic devices.
3 December 2012
An optical technique detects small objects buried in turbid media with high lateral resolution and without the damaging effects of ionizing radiation that x-ray can cause.
3 December 2012
A systematic engineering method improves the spectroscopic and structural properties of molecules that can be triggered by two-photon excitation to induce cancer cell death.
26 November 2012
A supervised segmentation technique classifies pixels in sub-cellular microscopy images into biologically meaningful regions with associated model bias quantification.
13 November 2012
Instruments for automated single-cell nanosurgery elucidate fundamental processes in biology, exploiting them in early detection and treatment of disease.
8 November 2012
A hybrid whispering gallery mode/plasmonic biosensor can detect and size the smallest known virus, so that no viral particle can evade detection.
2 November 2012
Haptic and multitouch computer interfaces enable a new kind of tangible experience in the study and manipulation of abstract mathematical objects and concepts.
23 October 2012
A new liquid-biopsy technique allows identification of abnormal cells in blood with one in a million sensitivity, enabling early cancer detection.
19 October 2012
Label-free, molecule-specific, high-speed biological imaging requires a functional and practical laser source.
8 October 2012
Spectrum compression of soliton pulses generates a narrow-linewidth pulse source that is rapidly wavelength-tunable across a broad range, making it suitable for novel applications.
5 October 2012
Direct modification of surfactant allows magnetic nanoparticle stabilization in water and attachment of different biomolecules in a single step.
27 September 2012
Advanced image-processing and machine-learning methods automatically detect fractures, segment hemorrhages, and classify outcomes.
26 September 2012
Craig BarrettThe former chairman of Intel weighs in on the Optics and Photonics report from the National Academies.
10 September 2012
A new type of system can potentially image rare circulating tumor cells with simultaneous non-invasive detection at a flow rate twice that of a human radial artery.
11 September 2012
After more than 20 years of academic research and industrial development, optical coherence tomography has found a new home in the interventional cardiology suite.
6 September 2012
A novel vertical-cavity surface-emitting laser with a microelectromechanical tuning element enables high-speed, centimeter-range optical coherence tomography.
20 August 2012
Combining microfluidic samples and pulse-shaping technology enables fast, quantitative detection of molecules, making an established visualization tool more broadly useful.
10 August 2012
Temperature-sensitive contrast agents and modulating tissue temperature with focused ultrasound allow high-resolution fluorescence imaging of thick tissue with quantitative accuracy.
3 August 2012
Easily implantable, thin, wireless modules of photovoltaic arrays elicit response from retinal neurons when activated by pulsed near-IR light and allow scaling-up to thousands of pixels.
30 July 2012
A novel combination of optical and electron microscopes results in a high-resolution optical nano-imaging system for biological applications.
23 July 2012
Interferometric phase microscopy measures transparent biological samples without labeling or physical contact with the sample, yielding a powerful and unique tool for research and medical diagnosis.
13 July 2012
A multiplexed fiber Bragg grating array and a plastic-coated optical fiber promise improved measurement of distributed pressure in medical applications.
10 July 2012
Metabolic photoacoustic microscopy can simultaneously measure the anatomical, chemical, and fluid-dynamic parameters required for absolute quantification of the metabolic rate of oxygen.
2 July 2012
Multiphoton endoscopes show potential as clinical instruments capable of real-time diagnostics and as replacements for surgical biopsies.
20 June 2012
High-performance, real-time, low-cost biosensing systems can be achieved using an indirect power-based technique to track the shift in the spectral response of a photonic bandgap structure.
20 June 2012
Recent developments in retinal image analysis enable the possibility of advanced computerized medical systems.
8 June 2012
A new optical technique can non-invasively determine the collagen structure in articular cartilage and could lead to improved understanding of arthritis.
23 May 2012
A new miniature imager captures full-field cerebral blood flow in ambulating rats based on high-resolution laser speckle contrast analysis.
17 May 2012
Applying a motion-analysis algorithm to optical projection tomography allows 3D reconstruction of the circulatory system of biological specimens in vivo.
1 May 2012
Effective non-invasive control of neural activity can be achieved with optically excitable quantum dots, tiny semiconductor particles nanometers across.
30 April 2012
Biophotonic techniques can monitor the pathophysiology of electrical burns.
5 April 2012
Optical measurements of tissue changes during photodynamic and radiation-based cancer treatments help to develop and improve these therapies.
2 April 2012
An experimental and theoretical comparison of silicon photonic resonators identifies which are most promising for implementing lab-on-chip diagnostic devices.
1 March 2012
Photobiostimulation is a novel noninvasive method to help protect neurons and repair injured neuronal pathways.
29 February 2012

Integrating highly efficient energy conversion materials onto stretchable and biocompatible substrates could yield breakthroughs in implantable biomechanical energy harvesting systems.

21 July 2011

Innovative imaging techniques as well as teaching methods have helped advance research at the biophotonics laboratory at Vanderbilt University.

15 June 2011
The optical coupling in triangular resonators increases the evanescent field, allowing them to be used to monitor biological events that affect the refractive index of the surrounding medium.
8 June 2011
A camera that operates at video frame rate offers a solution to stand-off imaging for search and rescue in fire disasters and label-free biomaterial detection.
8 June 2011
Screening digital holograms of living tissues in response to drug treatment indicates mechanism of action.
8 June 2011
A novel photosensitizer could lead to photodynamic therapy for in vitro inactivatation of the virus that causes acquired immune deficiency syndrome.
2 June 2011
New intelligent image-processing software examines chest x-rays for infections.
2 June 2011
A Raman spectroscopy-based clinical device rapidly detects and distinguishes melanomas from benign lesions.
11 May 2011
Optical coherence tomography shows promise in assessing cardiovascular development in mammalian model systems.
9 May 2011
One exposure to a near-IR laser four hours after a head trauma significantly improves neurological performance and reduces lesion size.
5 May 2011
Smaller, faster, cheaper optical biosensors offer the capacity to provide effective and actionable information.
28 April 2011
Boyden's award-winning research has led to tools that can activate or silence neurons with light, enabling the causal assessment of how specific neurons contribute to normal and pathological brain functions.
21 April 2011
Complex nanoparticle assemblies containing quantum dots and chemotherapeutics promise simultaneous imaging and targeted drug delivery in cancer therapy.
20 April 2011
A new method of controlling polarization under the objective lens could unlock hidden information and provide better 3D perspective.
11 April 2011
An ultrathin scanning-fiber endoscope uses 3D digital reconstruction of endoscopic video for automated analysis.
7 April 2011
A novel, noninvasive, controllable technique is suitable for high-resolution observation of subcutaneous structures.
7 April 2011

A turkey carcass played a key role in discovering the potential of the argon-fluoride excimer laser at 193 microns and its eventual widespread application in eye surgery.

4 April 2011
Using stimulated emission depletion microscopy and other techniques, Stefan Hell explores new ways to examine living cells noninvasively.
1 April 2011
Providing better information than traditional electrocardiography, this more noise-robust approach is more useful for tracking early development and diagnosing heart disorders.
31 March 2011
A new web-based system administers professional examinations in colposcopy.
30 March 2011
A diagnostic cytology-on-a-chip technique rapidly detects pre-malignant and malignant cells with high sensitivity and specificity.
28 March 2011
Light-irradiated metal nanoparticles or chromophores can produce localized chemical or physical effects on (sub)cellular structures.
18 March 2011
Mark ReaSolid-state lighting and the discovery of a new photoreceptor in the brain have stimulated the study of how light impacts biological systems.
15 March 2011
A terahertz external-cavity surface-emitting-laser source delivering milliwatt powers at any targeted frequency across the tHz gap could address a broad range of applications.
15 March 2011
Noninvasive, real-time imaging technology assists UV light therapy of skin diseases and facilitates reduction of the associated photodamage.
1 March 2011

Based in Jena, the birthplace of optical technology in Germany, JENOPTIK's Michael Mertin has a unique perspective on the industry's past and future.

28 February 2011
Zinc oxide nanostructures are suitable for sensitive and selective detection of extra- and intracellular metallic ions and other biological analytes, as well as for photodynamic therapy for cancer-cell treatment.
28 February 2011
Appropriate use of images, information graphics, and diagrams could help patients better digest medical information and provide an effective way of promoting empowerment and enhancing care.
28 February 2011
Cone-disk shedding and generation can be observed using transverse-scanning optical coherence tomography and scanning-laser ophthalmoscopy.
23 February 2011
Progress in microfluidics enables integration of all functionalities onto a single chip, allowing production of sample-in, answer-out devices that greatly speed up the analytical process.
22 February 2011
A proposed new photometric unit enables assessesment of the energy efficiency of a lighting solution with respect to its biological effectiveness.
22 February 2011
A novel imaging system based on a form of visual-light photon scattering provides real-time views of biological samples.
10 February 2011
Real-time detailed monitoring of angioplasty balloon deformation may lead to improved medical devices to treat hardened artery walls.
10 February 2011
Nanosensor devices made from metallic oxides can be used for breath analysis and disease diagnosis.
10 February 2011
A new scheme to correct scatter contamination for cone-beam computed tomography can lower the dose and improve the image.
9 February 2011
Audio recordings and slides from plenary presentations at SPIE Photonics West 2011.
7 February 2011
New developments in terahertz frequency imaging make it suited to assist in patient screening and diagnosis.
7 February 2011
Applying advanced imaging and analytical techniques to measure patterns in the makeup of dermal tissue could help our understanding of how skin changes over time.
4 February 2011

Clinical Multiphoton Tomography - Karsten Koenig presentation from BiOS Hot Topics session at SPIE Photonics West 2011

31 January 2011

New Developments in OCT for Ophthalmology - David Huang BiOS Hot Topics presentation at SPIE Photonics West 2011

31 January 2011
A nonlinear multiplex imaging technique reveals transformations in the cell during programmed cell death.
11 January 2011
A modular device that can detect and characterize the energies of individual x-ray photons could prove broadly useful in computed tomography and digital radiography.
29 December 2010
Wireless health aims at drastically reducing healthcare costs and loads by combining innovations in wireless sensing, embedded information-technology infrastructures, and medical fundamentals.
27 December 2010
A better understanding of how blood flow affects early cardiac development may lead to better prognoses and treatments of congenital heart disease.
20 December 2010

Training more high-school physics teachers and increasing student learning are two of the challenges facing math, science, and engineering education in the United States.

17 December 2010
The Human Connectome Project aims to reveal and understand the complex neural pathways supporting brain function.
7 December 2010

Reducing the cost will trigger a boom in lab-on-a-chip technology -- reusable or disposable paper chips may hold the key.

7 December 2010
Computer-facilitated histology image analysis may play an important role in clinical diagnosis of cancers and identification of prognostic and therapeutic targets.
7 December 2010
The vice president of engineering at CVI Melles Griot Laser Group talks about the company's evolution and efforts to serve the biomedical instrument market.
19 November 2010
Fluorescence images of human cell samples are a powerful tool for studying cancer migration.
15 November 2010
With properties that don't exist in nature, metamaterials open up an exciting range of possibilities.
10 November 2010
The ability of gold nanoparticles to act as efficient pointlike sources of both light and heat promises integrated functionalities for future point-of-care diagnostics and cancer therapies.
2 November 2010
Employing the sensitivity of grating interferometry constitutes a major advance in building artificial muscles to treat severe urinary incontinence.
27 October 2010
Using optical tweezers to control a single DNA molecule in a nanopore enables better understanding of forces exerted during membrane passage.
27 October 2010
The father of the FEL talks about current research and potential applications of the technology, from genetics to defense and security.
19 October 2010
An engineering tool has shown that the retinal structure aids in improving our vision acuity.
18 October 2010
New photon-counting cameras and multipixel photon-counting detector arrays are transforming single-molecule observational approaches.
13 October 2010
A new sheathless microfluidic-based flow cytometer promises to extend the capabilities of routine blood analysis at point of care and in resource-limited settings.
13 October 2010
Fine-engineered, tiny noble-metal particles can be used for targeted color imaging of cancer cells and potentially for therapy.
7 October 2010
Application of holographically ordered porous-polymer gratings and dry-etched porous silicon enhances optical sensing of oxygen.
24 September 2010
A novel system advances neurophotonics beyond its physical limitations using tools previously employed for multibeam optical manipulation.
24 September 2010
Novel plasmonic biodetection systems enable ultrasensitive biomolecular studies for early disease detection and treatment.
21 September 2010
Rare-earth fluorescent nanophosphors upconvert from near-IR to visible wavelengths to provide bright, low-noise images.
17 September 2010
A new strategy enables development of untethered microtools that function on exposure to specific biochemicals and without the need for any electrical power.
15 September 2010
Enhancements to semiconductor gamma cameras have reduced radiation exposure 3 to 5 fold.
13 September 2010
Ultrasonic standing waves allow concentration, washing, fractionation, or trapping against a flow of cells in microfluidic environments and can potentially enhance biosensor performance.
13 September 2010
A novel device consisting of electrodes for positive dielectrophoresis, combined with a system of channels and valves, can capture and compartmentalize cells for highly parallel single-cell analysis.
1 September 2010
A novel optical stabilization method extends the instrument's inherent precision and applicability to a wide range of perturbative operating conditions.
23 August 2010
A new, seamless, sample-to-answer technology (high-conductance dielectrophoresis) enables rapid analysis of high-molecular-weight DNA clusters and drug-delivery nanoparticles based directly on whole blood.
19 August 2010
Portable optical devices capable of real-time, in situ sensing and characterization of individual nanoparticles and pathogens could offer unprecedented benefits in a range of applications.
9 August 2010
Current methods for detecting the binding strength between molecules are slow and expensive, but new microfluidic methods are addressing these drawbacks.
9 August 2010
Future medical tests can be performed four times faster by modifying the supporting substrates of nano-electronic biosensors.
8 August 2010
An order-of-magnitude improvement is promised by new experimental and algorithmic techniques that are making subcellular imaging of biological samples a reality.
3 August 2010
Bacteria and other microbes have their own antifreeze molecules to preserve liquid water and sustain life in frozen environments.
27 July 2010
Tissue pathology can be detected in vivo by optical methods through minimally invasive endoscopy. Work at the BC Cancer Agency in Vancouver is focused on Raman spectroscopy of internal and external surfaces.
16 July 2010
Exploiting the versatility of nanoparticles results in more effective light-based destruction of tumor cells than can be achieved using conventional phototherapy approaches.
16 July 2010
Understanding biological-fluid evaporation on small scales facilitates development of advanced biomolecular-processing techniques for a broad range of biomedical applications.
8 July 2010
Gold nanorods are emerging as a powerful solution for various minimally-invasive biomedical applications, including laser bonding of connective tissues.
7 July 2010
Advanced microscopic techniques enable depth-resolved imaging of changes in blood flow during brain activation.
6 July 2010
Fast screening of antibody-secreting cells by extraordinary optical transmission could be a new mechanism for drug discovery.
6 July 2010
Genetically encoded tools enable activation and silencing of neurons with light, revealing how the brain works and facilitating potential new therapies.
10 June 2010

In his lab at Oregon Health and Science University, Jacques and his researchers have developed new modalities for diagnosis and treatment. He reflects on the laser's key role.

26 May 2010
Self-powered, integrated systems-on-a-chip are key to developing extremely low-power devices for applications in commercial, defense, space, harsh-environment, and medical settings.
26 May 2010
A new, lightweight, compact microscope is suitable for telemedicine applications in resource-poor settings.
19 May 2010

Nozomi Nishimura explains how researchers use femtosecond laser pulses to model and study the effects of stroke and Alzheimer's in brain cells.

30 April 2010
Katarina Svanberg laser interviewLasers have a multifaceted role in oncology, and have increased patient survival through their use in tumor detection and treatment.
16 April 2010
A novel microfluidic chip produces single-molecule containers with high precision, facilitating studies of chemical reactions at the lowest possible reagent levels.
12 April 2010

The clinical uses of PDT have expanded, and research is underway on a variety of cancers as well as infectious diseases.

19 March 2010
Lensfree on-chip holography can improve point-of-care diagnostics, even in the developing world.
16 March 2010
Microspheres inside capillaries or hollow waveguides permit compact focusing of light from multimodal sources.
12 March 2010
A newly developed detector for toxic industrial chemicals is highly sensitive, simple, fast, and inexpensive, and it works by visualizing odors.
3 March 2010
A novel imaging technique shows depth-resolved blood perfusion within the retina and choroid.
3 March 2010
A lab-on-a-chip-type system employs optical tweezers to study changes in the response of single yeast cells to variations in the immediate environment.
2 March 2010

The SPIE 2010 Gold Medal winner reminisces about the formative years of the laser, and talks about new horizons in science.

26 February 2010
The chief technology officer of LightLab Imaging talks about the company's efforts in developing optical coherence tomography products for clinical use.
25 February 2010
Electrothermal micromirrors and a flexible printed circuit board permit fast, small optical coherence tomography of internal organs.
22 February 2010
The constructive interference of coherent light inside microsphere cavities enables robust, ultrasensitive biosensors as observed from resonance-frequency shifts.
4 February 2010
The first integrated-circuit vocal tract, combined with a bionic ear processor in a feedback speech-locked loop, provides a new way to process speech.
3 February 2010
Novel optical systems show excellent properties for laser-induced fluorescence detection of dangerous aerosols, hydrosols, chemicals, and explosives.
2 February 2010

Nanoscopy with Focused Light - Stefan Hell plenary presentation from SPIE Photonics West 2011

31 January 2010

Novel Uses of Femtosecond Laser Pulses in Biophotonics - Eric Mazur presentation from the BiOS Hot Topics session at SPIE Photonics West 2011

31 January 2010

In this 10 minute presentation from the BiOS Hot Topics session at Photonics West 2011, Ed Boyden talks about his research at MIT.

31 January 2010
Jim Fujimoto works with students and patients to expand the clinical applications of biomedical optics.
21 January 2010
Absorption wavelength changes are caused by variations in the internal electric field of the proteins.
19 January 2010
Leon Esterowitz completed his PhD in the early 60s in the early days of the laser. After a career in defense, he moved to NSF, and now reviews funding proposals in biophotonics.
13 January 2010
Rox Anderson, symposium chair of SPIE Biomedical Optics at Photonics West, talks about the important role of lasers in medicine, from cancer to heart disease and his own specialty, dermatology.
5 January 2010
A novel approach to generating large-scale, 3D images allows tracking of individual collagen fibers and characterization of their structural organization.
30 December 2009
A novel approach that notably improves the photophysical properties of fluorophores enables development of advanced biomedical applications.
22 December 2009
Since cancer will eat away flesh and may kill, its efficient and effective detection at an early stage is important.
22 December 2009
Distance-dependent coupling of plasmon resonances between closely spaced metal nanoparticles offers an attractive approach for imaging molecular interactions.
18 December 2009
Synthetic chemistry enables creation of emissive nucleoside surrogates for applications in sensor development, discovery assays, and biophysical measurements.
18 December 2009
Applications of high-frequency ultrasound imaging will help reveal the nature of cancer spread.
17 December 2009
New, compact, and wavelength-optimized ultrashort-pulse laser systems may facilitate corneal grafting and enable new forms of glaucoma surgery.
9 December 2009
Integration of biological molecules into nanoelectronic devices promises new, sophisticated biointerfacing technologies.
9 December 2009
A new method for killing viral particles may have important medical applications like disinfecting blood components and treating diseases.
3 December 2009
Automated classification of individual blood-vessel abnormalities may improve the efficiency of a common test for autoimmune diseases.
18 November 2009
Combining a post-acquisition rearrangement procedure with optical coherence tomography can provide high temporal resolution for capturing subtle dynamics in the early avian embryonic heart.
17 November 2009
Spectral-domain optical coherence tomography performed simultaneously in two distinct wavelength bands permits better diagnosis of tumors.
9 November 2009
High-frame-rate, real-time laser Doppler imaging of biological tissue uses advances in optical sensing and processing.
30 October 2009
Using light to inject a single nanosized biosensor into a mammalian cell enables analysis of its biochemistry.
20 October 2009
The combination of microfluidics and plastic electronics could bring laboratory-quality analysis to the practitioner in the field.
16 October 2009
A new technique to remove complex-conjugate artifacts inherent to conventional Fourier-domain interferometry can double accessible imaging depth.
13 October 2009
An electro-optic lens with voltage-controlled focusing power across the aperture takes a new approach to adjusting vision as people age.
6 October 2009
Bioinformatic techniques enable identification of extremophile life forms well adapted to extraterrestrial environments such as Mars.
30 September 2009
A proposed model for migrating birds' magnetic sense can withstand moderate orientational disorder of a key protein in the eye.
23 September 2009
Transduction of molecular recognition by closely packed organic electronics and membrane proteins may enable accurate, label-free diagnostic testing.
23 September 2009
Determining the characteristic quadratic hyperpolarizability of amino acids for single molecules and short peptides enables advances in tissue imaging.
23 September 2009
Optical coherence microscopy has potential as a tool for noninvasively measuring electrical activity in single neurons based on changes in their intrinsic optical properties.
16 September 2009
Combining organic lasers with optical waveguides and microfluidic channels may enable inexpensive, disposable diagnostic tests that can be analyzed at the patient's bedside.
15 September 2009

From fabric that can process images to laser communication to brain surgery, Yoel Fink of MIT describes some of the uses of multimaterial fibers.

9 September 2009
Ancient weathering crusts are often the only source of information about the conditions under which development of our biosphere occurred.
4 September 2009
The former president of MIT spoke at the SPIE Optics + Photonics Symposium Awards Banquet.
13 August 2009
Fluorescent probes enable nondestructive, in situ microscale viscosity measurements.
7 August 2009
A wavelet method that employs Monte Carlo ray sampling fully accounts for diffraction and interference in complex media.
7 August 2009
The fabrication process can reduce multiple scattering effects and decrease pixel size, paving the way for improved x-ray, charged particle, and neutron detectors.
5 August 2009
Photodynamic therapy represents a paradigm shift in oncological medication from traditional resection and systemic chemotherapy methods.
22 July 2009
A large, dynamic-range Shack-Hartmann wavefront sensor allows the characterization of higher-order aberrations in keratoconic and post-corneal transplant eyes.
21 July 2009
Selective electrolysis of phosphate-buffered saline may provide oxygen directly to retinal tissue with minimal coproduction of harmful free chlorine.
15 July 2009
Characterizing how nanoparticles affect organs and accumulate in tissue may provide insight into their safety as a potential cancer therapy
15 July 2009
Polarization-sensitive optical coherence tomography enables tissue-sensitive visualization of the front of the eye.
9 July 2009
Improved understanding of the fundamental cellular and molecular mechanisms is broadening the technique's mainstream use for many ailments.
9 July 2009
A new system for ultrahigh-speed imaging of the anterior segment of the eye retains micrometer resolution.
6 July 2009
A novel approach enables user-defined manufacture of biocompatible and biodegradable polymer structures for regenerative medicine.
6 July 2009
Growing indium nitride film in a different orientation paves the way for noninvasive analysis of chemical composition.
1 July 2009
A new class of photonic-crystal fiber with a hollow core and various lattice modifications may be an important component for biosensing applications.
30 June 2009
A new data-capture method could provide increased flexibility for clinical imaging applications.
30 June 2009
A computerized tool gives radiologists a second opinion for diagnosing breast cancer.
30 June 2009
Intensity-based Doppler optical coherence tomography gives an accurate, high-speed, 3D readout of ocular blood flow.
24 June 2009
A new family of chemical labels with much longer lifetimes than traditional fluorophores are key to a new biological imaging method: time-resolved emission imaging microscopy.
24 June 2009
Sub-Angstrom-resolution sensing of tiny cantilevers is leading the way to a gentle physical probe for surfaces of materials such as living cells.
19 June 2009
Detailed, real-time imaging allows for adjustment of surgical margins, thus sparing healthy tissue and increasing the likelihood of complete tumor removal.
19 June 2009
Pressure waves caused by nanosecond laser pulses can be used to deliver macromolecules to cells and tissues.
16 June 2009
A new technique for monitoring blood flow will help investigate eye functions and retinal disease.
10 June 2009
Top SPIE Newsroom articles from the previous month, and papers from SPIE Journals and Conference Proceedings.
9 June 2009
Monitoring biochemical interactions can serve as the basis for many diagnostic techniques.
5 June 2009
A hybrid magnetic-resonance/fluorescence imaging system aids identification and study of tumors.
1 June 2009
By using optical nanocavity resonators, the interaction between the light and target molecules is enhanced more than a million times, leading to improved single-molecule detection.
26 May 2009
Laser-induced ultrasound can aid the early detection and monitoring of metastatic disease.
22 May 2009
Very detailed 3D scans of a 3000-year-old mummy of an Egyptian temple singer and priestess are made freely available for in-depth follow-up studies.
18 May 2009

Long wavelength light permits in vivo imaging of the human eye at a cellular scale.

18 May 2009
Electronics, sensors, and communication capabilities will all be embedded in future contact lenses, presenting new opportunities in applications ranging from medicine to virtual reality.
15 May 2009
A combination of waveguides and microfluidics is easily achieved through femtosecond-laser micromachining.
14 May 2009
By exploiting the extra information available from 3D imaging in a virtual reality environment, surgeons can individualize the pre-planning of surgery on the kidneys.
13 May 2009
Blindly separating images prior to applying tissue-contrast-enhancing algorithms shows clear improvements over current techniques.
12 May 2009
Innovations in photonics and microfluidics have enabled the development of a novel, rapid, sensitive, low-cost, and portable micro-gas analyzer.
4 May 2009
Recent advances in imaging technology facilitate cellular-resolution retinal imaging and wide-field 3D visualization, enabling enhanced penetration below the retina for routine diagnosis.
3 May 2009
This patent review from Nerac explores some new developments in retinal implants that may speed their acceptance for treating blindness.
1 May 2009
The successful demonstration of near-IR contrast agents brings non-nuclear diagnosis closer to clinical use.
29 April 2009
A combination of polarization and Doppler-flow imaging for optical coherence tomography enhances image contrast without sacrificing acquisition speeds.
24 April 2009
A Web-accessible, content-based system for searching a large cervigram database may play an important role in medical education and cervical-cancer research.
14 April 2009
A device combining optical coherence tomography and adaptive optics can capture micron-scale 3D pictures of the retina.
6 April 2009
Optical coherence tomography enhances clinical diagnosis and could increase our understanding of major disease progression.
25 March 2009
Even after multiple applications of sunscreen, the UV-blocking particles remain localized close to the skin surface and produce insignificant numbers of free radicals.
24 March 2009
Advances in monitoring the response to photodynamic therapy may permit real-time dosage adjustments, improving the outcome for patients.
17 March 2009
Individuals and organizations must work together to reduce pediatric radiation exposure.
13 March 2009

Margaret Wertheim describes her work on the Institute for Figuring.

3 March 2009
Diffusion imaging already offers an unprecedented view of the human brain's structure, but it is still an evolving field, providing opportunities for future technical and scientific developments.
3 March 2009
Innovations in microfluidic technologies enable rapid in vivo studies employing two-photon microscopy and femtosecond laser nanosurgery.
24 February 2009
An advanced imaging technique has both the spatial and temporal resolution to investigate the developing heart in important animal models such as chicks and mice.
24 February 2009
Near-IR fluorescent dye encapsulated in calcium-phosphate nanoparticles maintains enhanced brightness for up to four days in human breast-cancer tumors systemically injected into live mouse models.
9 February 2009
Satellite sensors track sources of desert dust for models that predict particle entrainment and atmospheric pollution, resulting in new tools to support public safety and health services.
9 February 2009
Plasmon coupling facilitates detection of direct contacts between optically colocalized gold nanoparticles in optical wide-field microscopy.
9 February 2009
A new operating regime for rapidly wavelength swept, narrowband light sources has enabled high-performance biomedical imaging.
3 February 2009
A tensor method applied to diffusion images provides better reconstructions of nerve fiber crossing than linear methods.
30 January 2009
See-through fish embryos help to demonstrate the advantages of an integrated approach in testing how small particles can alter living organisms.
23 January 2009
Novel fluorescence lifetime-based instrumentation and methodologies enable the development of near-real time clinical diagnostic devices for heart disease and tumors.
21 January 2009
Optical trapping and manipulation of carbon nanotubes using optical tweezers leads to next-generation photonic force microscopy.
19 January 2009
A water-resistant surface inspired by the lotus leaf could enable applications in microfluidics, underwater coatings, and controlled deposition.
19 January 2009
A sparse image model combined with a novel nonlinear reconstruction algorithm can obtain high-quality imaging with significantly fewer measurements than traditional approaches.
15 January 2009
Advances in optical-coherence tomography may lead to a new class of endoscopic, image-guided therapies that target disease with microscopic precision.
15 January 2009
Optical imaging systems that identify molecular signatures of cancer can address clinical needs in both the developed and the developing world.
15 January 2009
Illuminating bodily tissues with a digital micromirror device enables non-invasive characterization of living tissue based on chemistry and morphology.
31 December 2008
Combining semiconductor technology with photonics, optics, and biochemistry leads to sensors with improved biomedical diagnostic capability.
31 December 2008
An innovative single optical fiber configuration in medical probes promises unique capabilities for clinical diagnostics.
28 December 2008
A new diode-pumped solid-state laser offers the technology to complete the triad of red, green, and blue sources needed to produce full-color images.
24 December 2008
Microfabrication and assembly techniques can build high performance miniature microscopes for clinical diagnostics.
22 December 2008
Tools employing low-energy radiation are being developed for clinical applications where knowing the full extent of disease is vital.
16 December 2008
Semiconductor devices based on high-electron-mobility transistors can be functionalized for specific applications.
16 December 2008
Computed tomography colonography employing partial volume image segmentation improves detection of the colonic mucosa layer and thus of potentially cancerous polyps.
15 December 2008
Ablating a biological sample leads to atomization of a small amount of material in a hot, light-emitting plasma that can then be effectively analyzed.
15 December 2008
A near-IR-based portable device can identify and localize suspected brain bleeding in trauma patients.
15 December 2008
The light-absorption properties of this accidentally discovered material promise sweeping advances from cameras to solar cells.
8 December 2008
Integration of highly sensitive photonic biosensors and microfluidic technologies provide new possibilities for molecular diagnostics.
3 December 2008
A model that captures how people view a multilayer 3D terrain may lead to better visualization schemes.
1 December 2008
Combining broadband near infrared spectroscopy and magnetic resonance imaging of breast tissue allows more accurate quantification of the constituents in suspected tumors.
1 December 2008
Quantum-dot nanoprobes enable real-time quantitative noninvasive assessment of epidermal growth-factor receptor in animals transplanted with human cancer cells.
24 November 2008
By raising the temperature in tumors, optically activated nanoparticles can make existing treatment more powerful.
17 November 2008
A physical model of image formation combined with a reconstruction algorithm results in superior optical projection tomography reconstructions.
6 November 2008
Computational approaches to optoacoustic tomography allow optimization of imaging systems for biomedical applications and efficiency testing of image-reconstruction algorithms.
5 November 2008
Advances in background-noise reduction lead to ultrasensitive protein and DNA sensors for detecting oral cancer.
22 October 2008
Observing surface-texture evolution of nanocrystalline films in situ using reflection high-energy electron diffraction aids in creating novel nanostructures.
20 October 2008
Nanoparticles doped with lanthanides such as holmium and thulium possess useful optical properties for a range of applications including computer displays, lasers, and bioimaging.
15 October 2008
Feedback control systems combine models and experimental data to guide thermal treatments of tumors.
6 October 2008
A new fiber-based probe may enable surgeons to simultaneously view and eliminate individual cells.
6 October 2008
Combining light and ultrasound in a single hybrid technology enables multiscale, high-resolution imaging deep into biological tissue.
22 September 2008
Quality of life studies after laser eye surgery complications may provide impetus to further improve technology.
5 September 2008
First principles in quantum mechanics reveal nature's upper boundary concerning the speed and efficiency of optical technologies, with practical consequences for electro-optics devices and applications.
29 August 2008
Extract, quantify, and interpret intrinsic tissue polarimetry characteristics using a novel Mueller matrix decomposition approach.
29 August 2008
Minimally invasive microsystems employing flexible, thin, compliant substrates and optical or electrochemical detection methods can monitor a wide variety of biomolecules just under the skin surface.
20 August 2008
A new 3D computational approach constructs realistic optical phase contrast microscope images of gold nanoparticles in biological cells.
19 August 2008
New two-photon–activated porphyrin designs allow specific, noninvasive targeting of subcutaneous tumors several centimeters below the skin surface.
14 August 2008
Adding a special lens between an object and a conventional optical microscope can improve image resolution to below the diffraction limit at visible wavelengths.
1 August 2008
New magnetic resonance imaging processing tools allow white-matter fiber bundles to be segmented and tracked in regions of high complexity.
30 July 2008
The detonation of silica-gold nanoshells at energy levels safe for normal tissues and their unprecedented low threshold for vapor bubble formation in solution highlight an advance in cell-killing nanotechnology.
11 July 2008
The in vivo study of the melanin absorption spectrum offers promises of characterizing melanin and associated pathological conditions in their native environment.
8 July 2008
Decay profiles of the local fluorophore environment can provide new opportunities to study biological tissue and cell signaling.
7 July 2008
Advanced imaging near the surface of tissues could assist the development of novel therapeutic agents, drug delivery systems, and diagnostic tests.
20 June 2008
A new approach to automatically identify individuals offers a high level of security while reducing the noise.
17 June 2008
A novel approach to noninvasive assessment of suspicious lesions promises better results with potential for immediate clinical application to tumor diagnosis.
11 June 2008
A project based on biophysics aims to improve the diagnosis, planning, and treatment of cardiovascular disease.
1 June 2008
High-resolution imaging and guidance using optical coherence tomography (OCT) can transfer diagnostic capabilities from the pathology lab to the operating room, enabling real-time tissue visualization and point-of-care decisions.
31 May 2008
The new class of contrast enhancement agents can be precisely tuned to aid in vivo photoacoustic tomography.
12 May 2008

David A. Benaron, CEO of Spectros, has enjoyed a successful career as a physician, researcher, inventor, innovator, and serial entrepreneur by staying focused on the market.

5 May 2008
A gray-scale mask for x-ray lithography, made using microelectromechanical systems technology, offers a new approach to manufacturing needle arrays.
5 May 2008
Polychromatic light-emitting diodes that incorporate 3D faceted microstructures provide good control of color, including pure white emission, without depending on phosphors.
29 April 2008
A device that combines an avalanche-mode amorphous selenium photoconductor with a field-emitter-array readout could provide high-resolution x-ray images at low doses.
29 April 2008
Increased temporal sampling rates make it feasible to quantify lung perfusion using 4D computed tomography.
15 April 2008
Hyperspectral methods using acousto-optic and digital micromirror devices have the potential to improve imaging speed and accuracy with an expanding range of uses, including clinical diagnostics.
15 April 2008
A high-power fiber-based spontaneous emission light source with a tunable filter can be ideal for Fourier-domain optical coherence tomography systems used in biomedical applications.
10 April 2008
Microchambers in photostructurable glass enable the dynamic observation of aquatic microorganisms.
7 April 2008
Wavelength-selectable high-peak-power picosecond optical pulses yield more detailed imaging of biological tissues.
30 March 2008
An assessment method that incorporates focal-spot blurring and scattered radiation optimizes the performance of a fluoroscopic detector.
27 March 2008
Innovative applications include terahertz pulsed spectroscopy for solid-state analysis and terahertz pulsed imaging for tablet coating analysis.
25 March 2008
Using a 4D computed tomography technique, it is possible to trace a tumor's 3D trajectories during a breathing cycle, increasing the probability of a successful treatment.
21 March 2008
In 3D ultrasound images, the ribs can be used as the pivotal reference point for defining the breast region.
13 March 2008
Quantifying placental calcification and infarction aids the obstetrician in assessing these well-established indicators of potential complications.
5 March 2008
Preliminary results from an automated system for analyzing breast lesions suggest that it performs comparably to a breast radiologist.
5 March 2008
Biomolecular motors enable active transport in biology, potentially making possible active materials capable of rearranging their components, or even molecular conveyor belts and forklifts for manufacturing at the nanoscale.
27 February 2008

A low-noise silicon hard x-ray imaging device promises improvement over conventional technologies for future astronomical missions and medical applications.

26 February 2008
Optical approaches provide robust and relatively non-invasive methods for excitation and detection of the motion of micro- and nanomechanical structures.
25 February 2008
The implementation of a JPEG2000 Interactive Protocol–based communication system allows rapid access to high-resolution medical images from low-power handheld devices.
25 February 2008
Near-IR light treatment modifies cellular function, promotes cell survival, and improves outcomes in laboratory and mouse models of Parkinson's disease.
24 February 2008
Micro x-ray imaging tracks nutrients pumped though porous synthetic tissue scaffolds by rhythmic squeezing.
22 February 2008
A stationary tomosynthesis mammography system with a carbon nanotube-based x-ray source array can shorten imaging time and improve image quality.
20 February 2008
Linking changes in arterial microstructure with fluid dynamics of blood flow provides a detailed account of how aneurysms develop.
15 February 2008
A computer-aided detection system uses sagittal proton-density-weighted magnetic resonance images to detect meniscal tears in the knee.
13 February 2008
Nanophotonics has huge application potential in medicine, provided that concerns about toxicity can be addressed.
5 February 2008
Novel swept light sources find applications in optical coherence tomography imaging systems.
5 February 2008
A digital holographic technique has an extended measurement range and improved resolution at infrared wavelengths.
4 February 2008
Femtosecond pulse technology can isolate and penetrate embryonic cells for delivery of nanoparticles and DNA.
28 January 2008
Longer wavelengths from a tunable laser improve performance for angioplasty, lithotripsy, and mass spectrometric protein analysis.
26 January 2008
High-sensitivity compact gas-sensing devices may soon replace current bulky detectors used in industry and medicine.
10 January 2008
A large surface area with easily modified chemistry makes porous silicon an effective transducer for optical biosensing.
10 January 2008
Focus engineering of coherent anti-Stokes Raman-scattering microscopy enhances biomedical imaging capabilities.
9 January 2008
A new technique for targeting viral capsids may be applicable to a wide variety of pathogens.
21 December 2007
Extremely thin, flat plasma lamps can illuminate broad areas and have potential applications in medicine and other fields.
19 December 2007
Using a common chemical reaction to produce an easily detected gas simplifies the measurement of breath acetone for medical diagnostics.
6 December 2007
A low-cost, noninvasive means of imaging red blood cells shows promise in applications aimed at assessing tissue viability.
2 December 2007
Microsystem technology is an emerging approach to flow cytometric blood cell analysis based on impedance, fluorescence and light scattering measurements.
19 November 2007
Throwaway devices may be the key to bringing high-performance sensors to market for use in medical applications.
6 November 2007
With minor system modifications and the addition of a high-repetition-rate laser, a commercially-available ultrasound imager can produce optoacoustic images for medical applications.
6 November 2007
The new operating rooms of Varese Town Hospital incorporate a computerized image acquisition and distribution system that can be used in medical education.
25 October 2007
The spatial conformation of surface-bound biomolecules is clarified using a new sensor that could prove useful in biomedicine.
25 October 2007
Ultrasound-induced modulation permits the collection of fluorescence images from deep within light-scattering media.
3 October 2007
The use of digital optics to compensate for aberrations simplifies the digital holographic microscope while increasing the accuracy and resolution of full-field phase measurements.
3 October 2007
Two-photon fluorescence microscopy can be used for non-invasive skin cancer diagnostics and topical drug delivery investigations.
30 September 2007

Early diagnosis increases the likelihood of effective cancer treatment. Nanotechnology offers several ways to improve patient outcomes.

14 September 2007
A wireless address event representation protocol could find use as a low-power, asynchronous system to record neural activity and act as an interface between prosthetic devices and the brain.
10 September 2007
Combining Raman spectroscopy with chemometric analysis allows the rapid identification of single microbial cells without the need for time-consuming microbiological cultivation methods.
5 September 2007
Microdialysis may offer advantages over current methods of performing essential blood measurements by sampling intracellular fluid with a catheter placed beneath fatty tissue.
27 August 2007
Mass spectrometry can be used to identify the biomolecular species present in laser-ablated material from bone and teeth.
23 August 2007

Harold Szu discusses wellness engineering and how technology developed for the military can help monitor diseases such as diabetes.

16 August 2007
A fast-response integrated opto-chemical sensor system can detect ultra-low concentrations of ammonia with high reproducibility.
8 August 2007
Total-internal-reflection fluorescence can be exploited to study real-time biomolecular binding processes with enhanced signal-to-noise ratio.
1 August 2007
The imaging of axonal fibers and connectivity in the human brain are improved by grouping anatomically similar fibers.
31 July 2007
Eye aberration measurements can be used in wavefront-guided laser ablation and clinical research applications.
25 July 2007
Create personalized computer eye models to simulate an individual's vision quality using optical and mechanical engineering software.
17 July 2007
Offering possible advances in everything from computing to spectroscopy, plasmonics represents a powerful technology.
16 July 2007
Nanometer-sized gold particles interacting with electromagnetic fields, fluids, and biological objects can be visualized using a specialized imaging technique combined with dark field microscopy.
4 July 2007
By providing an integrated approach to alleviate the current fragmentation of relevant information, a novel data management system will have a major impact on the treatment of cerebral aneurisms.
26 June 2007
Rats with genetically encoded color probes such as green and red fluorescent protein have been developed for specific biomedical research applications.
21 June 2007
A 3D extension of the standard will support cuboid volumetric data sets with no time component.
19 June 2007
A new approach in optical architecture promises small-scale, high-resolution in vivo imaging for medical applications.
29 May 2007
A microdevice equipped with polarizing filters and an organic photodiode enables detection of dye concentrations in the low nanomolar range.
23 May 2007
A variety of alternative approaches to 3D microscopic imaging can overcome various shortcomings and expand the range of areas and applications.
13 May 2007
Digital off-axis holography with coherence-domain depth gating can measure subcellular motion inside tumors that respond to anticancer drugs affecting the cytoskeleton.
13 May 2007
A smart microfluidic control system that is capable of monitoring clinically-relevant parameters can sample, dispense, and deliver biological fluids to a sensing unit.
10 May 2007
Theodore Maiman, who died in May 2007, is known for creating the first working laser out of a discredited material -- ruby -- in May 1960.
9 May 2007
The two-photon-polymerization process may be used to create medical devices such as middle ear prostheses that are specific to individual patients.
4 May 2007
Automatic search and retrieval methods applied to a large brain dataset can extract valuable additional information.
4 May 2007
Incorporating gold nanoparticles into viral protein provides a tool for studying viruses.
5 April 2007
High-resolution optical coherence tomography serves both as a noninvasive observation method and a therapeutic tool in chronic skin diseases such as scleroderma.
3 April 2007
Anisotropic surface roughness enhances the bending response of ionic polymer-metal composite artificial muscles.
30 March 2007
The noted researcher in biomedical optics discusses new imaging techniques involving nanotechnology, plasmonics, and the use of molecular sentinels for biosensing and diagnostics.
27 March 2007
An improved technique for selecting and immobilizing biomolecules in microstructures promises more-effective patterning of proteins and cells for microtechnology applications.
22 March 2007
Combining spectroscopy and imaging with computational pattern recognition may provide a fast, non-invasive way to detect and diagnose diseases near the body surface.
22 March 2007
Laser gas analyzers are an efficient way to study variations in gas-exchange processes between vegetation and the atmosphere under anthropogenic stress.
20 March 2007
Laser-induced explosion of absorbing nanoparticles, so-called nanobombs, can kill cancerous cells.
20 March 2007
Double-clad photonic crystal fibers and microelectromechanical mirrors significantly improve the sensitivity and miniaturization of nonlinear optical endoscopes.
20 March 2007
A laser-based technique can monitor sap flow in trees, solving a long-standing problem in plant biology with additional implications for climate change modeling.
20 March 2007
A low-cost retro stereoscope for virtual reality and other immersive applications uses flat-panel LCDs and achieves high field-of-view with high resolution.
20 March 2007
Birefringence and transparency of selected liquid crystals at terahertz (THz) frequencies promise added functionalities for liquid-crystal-based THz photonic elements such as phase shifters and filters.
20 March 2007
A laser-based technique can monitor sap flow in trees, solving a long-standing problem in plant biology with additional implications for climate change modeling.
20 March 2007
This month's featured patent review by analysts from Nerac
12 March 2007
RF-controlled battery-less microvalves are fabricated on a biocompatible substrate that allows for communication and remote actuation.
5 March 2007
New photodynamic cancer therapies combine the tumor detection and imaging capabilities of nanoparticles with the increased penetration depth of infrared two-photon excitation.
27 February 2007
Lateral shear interferometry combined with digital holographic microscopy can provide quantitative optical phase measurements with the use of a new, single image, reconstruction procedure.
20 February 2007
Varying pH makes it possible to control conformational changes of polymer chains attached to stimuli-responsive interfaces.
19 February 2007
The light-scattering signatures of bacterial colonies, which depend on minute genetic differences, may provide a way to rapidly identify pathogens in the food supply.
16 February 2007
As temperature changes, the change in backscattered ultrasonic energy is nearly monotonic, thus potentially enabling noninvasive 3D temperature imaging.
12 February 2007
In this video of his Photonics West presentation, David Krohn shares expert advice and perspective on the market potential, technology, opportunities and barriers in biophotonics.
5 February 2007
Polymer layers for microarrays patterned by laser ablation adsorb biomolecules only in specified regions and improve solid-phase transfection of cells when a voltage is applied.
5 February 2007
Optical interferometry reveals tiny motions in live cells that convey information about membrane properties and disease.
4 February 2007
Infrared spectroscopy combined with statistical analysis can identify and discriminate among vegetative bacteria, bacterial spores, and background interferents.
30 January 2007
Combining time-resolved photon counting, scanning optical techniques, and atomic force microscopy provides new tools for single-molecule investigations.
30 January 2007
A novel band selection technique developed for feature extraction of hyperspectral images uses a heuristic optimization algorithm.
29 January 2007
A thin-walled glass microfluidic channel can incorporate multiple optical ring resonators around the capillary diameter to act as sensors on a high-throughput lab-on-a-chip platform.
25 January 2007
Combining a deformable mirror with a super-resolution algorithm enables higher-resolution images from a relatively simple system.
22 January 2007
A new viewer can form enhanced pictures of objects in the dark, without the use of a camera or display.
18 January 2007
Thermal lens microscopes and microchemical chips aid in miniaturizing functional chemical laboratories.
18 January 2007
The high circulating intensities in ultrahigh-Q optical microresonator sensors improve their sensitivity enough to detect a part per million of heavy water in water.
8 January 2007
Technology developments have enabled the deployment of hyperspectral sensors to new application areas.
4 January 2007
An antibiotic can mitigate low-intensity microwave damage to red blood cells by reorganizing the structure of water.
14 December 2006
Femtosecond excitation around 1μm offers prolonged, in vivo imaging of biological structures using nonlinear multimodal and fluorescence-lifetime imaging microscopy.
14 December 2006
Fluorescence spectroscopy combined with new diagnostic algorithms can be used to differentiate between early-stage benign and malignant skin lesions.
13 December 2006
A new technique for performing minimally invasive surgery inside the beating heart provides a visual representation of the surgical environment.
13 December 2006
Microscale approaches to depositing liquids on surfaces are suitable both for making biomolecule microarrays and as tools for rapid prototyping.
12 December 2006
Three-dimensional imaging and simultaneous time-lapsed tracking of many objects is now possible in environments such as the deep ocean.
12 December 2006
Direct laser ablation produces waveguides, micro-channels, and optical circuits in a single processing step, which could drastically reduce manufacturing costs.
30 November 2006
The latest featured patent review by analysts from Nerac examines new developments in laser eye surgery.
29 November 2006
Both light scattering and fluorescence of membrane glycoproteins can be used to detect programmed cell death (apoptosis) quickly and cheaply.
29 November 2006
A novel bioelectronic sensing device offers several potential advantages, including mechanical flexibility, and reduction in weight, power consumption, complexity, and fabrication cost.
21 November 2006
A new optical microscope that uses computed tomography and a novel transformation algorithm can provide pathological information about specimens, and distinguish healthy from cancerous tissues.
8 November 2006
Life scientists can capture the internal structure of samples with high resolution and minimal damage using adaptive-optics techniques borrowed from astronomy.
5 November 2006
Silicone materials and broadband optical interrogation dramatically improve the sensitivity of small interferometric fiber pressure sensors of relevance to biomedicine.
5 November 2006
Substrates for sensitive surface-enhanced Raman spectroscopy are made from nanorod arrays prepared by oblique angle deposition.
1 November 2006
A hierarchical detection algorithm quickly finds and isolates critical regions in low-quality imagery.
31 November 2006
The interference of two nonlinear optical signals generated in series can improve image quality in coherent anti-Stokes Raman scattering microscopy.
26 October 2006
Real-time detection of nanoparticles and cells, including cancer, is now possible in blood and lymph flow.
23 October 2006
Ultrashort laser pulses can be used to produce lesions in single blood vessels located in the cortex of live rats, thus enabling the study of microstrokes.
19 October 2006
A low-cost computer-aided system could screen for early signs of diabetic retinopathy, a treatable disease that is the leading cause of blindness in working-age adults in the industrialized world.
18 October 2006
Confocal microscopy in combination with higher-order laser modes can detect and distinguish individual metallic nanoparticles from a single scattering image.
16 October 2006
Activating drugs with light could be better used to fight disease by first simulating the optical properties of the light source and the body tissues being treated.
10 October 2006
Exposing polymers to UV could ease fabrication of cell-coated medical implants and cell micro-arrays for high-throughput screening.
9 October 2006
A freely available software platform can help researchers rapidly and safely prototype systems for surgical applications.
6 October 2006
Display characteristics vary with the kind of monitor under inspection and the method of testing.
4 October 2006
High-speed addressable optical elements enable fast recording of rapidly-changing cellular signals in light-scattering biological tissue.
25 September 2006
An integrated module based on nematic liquid crystal technology has an accuracy better than 1%.
19 September 2006
Florida State University is adapting educational websites it has built to cover the increasing application of optical microscopy in the biological and materials sciences.
13 September 2006
Radiologists can generate better reports by using interactive visualization tools, thereby improving physician efficiency and efficacy in diagnosing pathologies.
10 September 2006
Digital-holographic microscopy can measure the refractive index and thickness of human pancreatic tumor cells and can be used to analyze their morphology.
6 September 2006
A 3D optical imaging system may provide a fast and non-destructive technique to visualize and identify living specimens.
5 September 2006
A visual fixation monitor employs four spots of linearly polarized light impinging on different parts of the bow-tie pattern of polarization states reflected from the eye.
31 September 2006
A low-cost, safe, and easy-to-use imaging system lets a surgeon see surgical anatomy and invisible fluorescence: this both simultaneously and in real time.
17 August 2006
A dual-color fluorescent microscopy system captures the behavior, in real time, of cancer cells as they grow and spread in live mice.
16 August 2006
A combination of experiments and computational modeling show how ultrafast laser pulses are able to bore into glass without heat-related damage.
11 August 2006
New diode-pumped solid-state lasers doped with thulium can be wavelength-tuned around the local water absorption peak at 1.94μm, making them attractive as versatile laser scalpels.
10 August 2006
Thermal energy intensities generated by surface-plasmon resonance can probe the behavior of molecular structures one flexible bio-molecule at a time.
9 August 2006
Researchers combine photonics and nanotechnology to improve drug development and disease detection.
8 August 2006
A novel system using a 3D handheld navigation device allows users to explore volumetric imaging data.
1 August 2006
Ambient light and display luminance contribute significantly to diagnostic viewing conditions in the digital radiology reading room.
13 July 2006
New reagents and techniques in cell biology make it possible to visualize cell-signaling mechanisms in real time.
10 July 2006
A novel system for imaging electrical activity in the heart can aid in diagnosis, therapy, and development of new treatment strategies.
10 July 2006
Wireless tracking technology integrated with facial biometrics can improve security in health care facilities.
7 July 2006
The viewing angle of a 3D display based on integral imaging can be increased by adding a flat holographic array that acts as a virtual lens.
19 June 2006
In rooms for on-screen viewing of medical images, LCD monitors used with brighter ambient lighting can reduce eye strain without compromising image contrast.
19 June 2006
The dispersive properties of photonic crystals can be used to fabricate compact devices with a wide range of potential applications.
6 June 2006
Pulsed infrared laser light provides a new method for nerve stimulation with unmatched precision, and could soon be used in medical procedures.
25 May 2006
A new Raman system, consisting of optic fiber bundles coupled to an axial Raman spectrometer, shows potential for skin cancer detection.
15 May 2006
Detecting specific drug penetration in biotissue may be feasible in vivo without tissue destruction or conventional lab sample analysis.
5 May 2006
A hand-held scanning probe permits easy, rapid, real-time functional and morphologic imaging of cellular and subcellular structures inside living specimens.
1 May 2006
A real-time 3D laser-manipulation system can be used to assemble, organize, and actuate particles, microtools, and living cells.
1 May 2006
A prototype chemical device can perform micro-stirring, pH measurement and control, and even the sensing of single molecules.
1 May 2006
Nanochannels with diameters from 15nm to 100nm were fabricated and used to isolate the fluorescence signal from a single molecule.
28 April 2006
Recent developments in source and sensor technology are leading to new scientific and commercial applications for terahertz radiation.
28 April 2006
The liquid/solid interface provides an ideal environment to investigate self-assembly phenomena and to probe the structure and properties of monolayers at the nanoscale.
26 April 2006
Large, high-performance transducer arrays for medical diagnostics and therapeutic applications can now be realized using CMUTs
20 April 2006
Reconstruction and manipulation of amplitude and phase of the optical field in virtual numerical space generates unique microscopic images
20 April 2006
Electrically conducting plastics and nanoparticles aid simultaneous measurement of the activity of many genes.
19 April 2006
Laser-induced photothermal effects on individual living cells have both diagnostic and therapeutic applications.
17 April 2006
Splitting a model of the colon into two halves and having a virtual camera 'fly over' each one helps the physician detect colon polyps.
17 April 2006
The development of optical multiarray biochips is essential for the immediate rapid screening of patients.
17 April 2006
A new platform of photoluminescent sensors excited by an array of OLED pixels is being developed for a broad range of medical, environmental, and industrial applications.
2 April 2006
Developing low-cost broadband semiconductor IR sources that could enhance the performance and resolution of OCT systems.
1 April 2006
A technique that allows soft x-rays to be focused using reflective elements that mimic a lobster's eye is extended to hard x-rays.
21 March 2006
A new approach based on multi-element source-detector arrays enhances the spatial resolution and depth-discrimination capability of diffuse optical imaging.
13 March 2006
Field-programmable gate arrays (FPGAs) can implement high-performance coprocessors that accelerate volumetric pattern matching by 100-1000 times as compared to PCs.
6 March 2006
A fiber-based femtosecond laser takes advantage of photonic-crystal fiber technology to extend the tuning range to more than 200nm, making it a potential source for biomedical imaging.
3 March 2006
By applying near-infrared en-face OCT to paintings, we can examine the optical properties of the varnish and paint layers, drying processes, and the underdrawings.
7 February 2006

A practical upgrade path from conventional film-screen to digital mammography uses tiled complementary CMOS imagers.

7 February 2006

Laser Doppler imaging (LDI), used for measuring in-vivo blood flow in biological tissues such as skin or brain tissue, has dramatically improved by exploiting high-speed CMOS image sensor technology.

7 February 2006
A new microchip analyzes thousands of cells per minute in an enclosed microfluidic environment.
7 February 2006

An array of laser diodes and semiconductor amplifiers should be able to physically model the operation of the brain.

7 February 2006
New fiber-optic sensor systems enable non-destructive plant biotechnology monitoring.
1 February 2006
From oemagazine October, 2005
30 October 2005
For the 2005 Gold Medal of the Society recipient, H. John Caulfield, "one thing led to another" is more than just a cliché.
1 August 2005
From oemagazine June/July 2005
31 May 2005
From oemagazine June/July 2005
31 May 2005
From oemagazine May 2005
30 May 2005
From oemagazine May 2005
30 May 2005
From oemagazine April 2005
31 April 2005
From oemagazine February 2005
31 February 2005
From oemagazine February 2005
31 February 2005
From oemagazine June/July, 2005. astrobiology
31 January 2005
From oemagazine January 2005
31 January 2005
From oemagazine November/December 2004
31 November 2004
From oemagazine September 2004
31 September 2004
From oemagazine August 2004
31 August 2004
From oemagazine July 2004
30 July 2004
From oemagazine June 2004
31 June 2004
From oemagazine February 2004
31 February 2004
From oemagazine January 2004
31 January 2004
From oemagazine January 2004
31 January 2004
From oemagazine January 2004
31 January 2004
From oemagazine November/December 2004
31 January 2004
From oemagazine December 2003
30 December 2003
From oemagazine December 2003
30 December 2003
From oemagazine November 2003
31 November 2003
From oemagazine November 2003
31 November 2003
From oemagazine November 2003
31 November 2003
From oemagazine November 2003
31 November 2003
From oemagazine November 2003
31 November 2003
From oemagazine September 2003
31 September 2003
From oemagazine September 2003
31 September 2003
From oemagazine August 2003
31 August 2003
From oemagazine July 2003
30 July 2003
From oemagazine July 2003
30 July 2003
From oemagazine July 2003
30 July 2003
From oemagazine June 2003
31 June 2003
From oemagazine April 2003
31 April 2003
From oemagazine March 2003
28 March 2003
From oemagazine March 2003
28 March 2003
From oemagazine March 2003
28 March 2003
From oemagazine February 2003
31 February 2003
From oemagazine February 2003
31 February 2003
From oemagazine January 2003
31 January 2003
From oemagazine January 2003
31 January 2003
From oemagazine September 2002
31 September 2002
From oemagazine July 2002
30 July 2002
From oemagazine April 2002
31 April 2002
From oemagazine March 2002
28 March 2002
From oemagazine February 2002
31 February 2002
From oemagazine February 2002
31 February 2002
From oemagazine January 2002
31 January 2002
From oemagazine December 2001
30 December 2001
From oemagazine November 2001
31 November 2001
From oemagazine September 2001
31 September 2001
From oemagazine September 2001
31 September 2001
From oemagazine September 2001
31 September 2001
From oemagazine July 2001
30 July 2001
From oemagazine February 2001
31 February 2001
From OE Reports Number 204 - December 2000
30 December 2000
From OE Reports Number 202 - October 2000
30 October 2000
From OE Reports Number 201 - September 2000
31 September 2000
From OE Reports Number 200 - August 2000
31 August 2000
From OE Reports Number 200 - August 2000
31 August 2000
From OE Reports Number 200 - August 2000
31 August 2000
From OE Reports Number 195 - March 2000
29 March 2000
From OE Reports Number 194 - February 2000
31 February 2000
From OE Reports Number 193 - January 2000
31 January 2000
From OE Reports Number 193 - January 2000
31 January 2000
From OE Reports Number 186 - June 1999
31 June 1999
From OE Reports Number 186 - June 1999
31 June 1999
From OE Reports Number 159 - March 1997
28 March 1997
From OE Reports Number 157 - January 1997
31 January 1997