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ASI/Applied Scientific Instrumentation
Company Description
Applied Scientific Instrumentation (ASI) manufactures hardware for laboratory and microscope automation including extremely precise closed-loop DC servo motor XY stages and Z drives for submicron motion control, piezo-Z stages for ultra-precise and fast Z-axis focusing with nanometer resolution, laser-based feedback systems for maintaining submicron focusing for days, video & LED based autofocus systems, open-loop stepper motor stages for use with existing OEM controllers, high-speed filter wheels and shuttering devices for illumination control, video microscopes and custom optical systems, microinjectors and micromanipulators for intercellular injections, cameras and photometric systems for imaging and quantification. We provide submicron motion control with XY stages ranging from 100 x 100 mm up to 300 x 300 mm. We also offer a wide range of other devices, and work directly with end users as well as a wide range of OEM's and imaging partners, to provide anything from individual components to fully automated turn-key systems. Our core competency in motion control, illumination and optics coupled with over twenty years experience working with cutting-edge researchers allows us to provide efficient and reliable solutions. ASI’s products are designed for long life under demanding applications and are backed with unparalleled support.
Contact Information
 29391 W Enid Rd
Eugene,OR
United States
Press Releases
| Rapid Automated Modular Microscope (RAMM) System
The RAMM system’s modular design allows a custom system to be easily developed. The microscope is configurable with infinity-corrected optics, dichroic filter cubes, multi-wavelength excitation and emission filterwheels, and detectors including cameras and photomultipliers. A wide range of automated features can also be added; these include: high-speed XY stages, precision piezo & motorized Z focusing, laser based auto-focus, and a robotic specimen loader. The system provides a solid platform for high throughput screening, genetic sequencing, experimental research, and much more. It has been designed for flexible cost-effective OEM development using high quality high MTBF components to reduce cost and increase customer satisfaction. |
| Cutting edge technology for ultra precise motion control, automated inspection & super resolution microscopy
Dig-Buster©
Thin-Film Inspection System
ASI’s automated thin-film inspection system uses ASI’s precision closed-loop DC servo motion control technology and video image analysis to optimize inspection. The goal is to optimize the productivity of human expert resources by offering relief from hours of tedious manual inspection. The system automatically flags potential defects like scratches and digs for expert re-inspection as needed.
The system interface permits simple production setup and scanning of thin-film specimens. Flagged objects of interest on color-coded maps are displayed for review and notation by an expert technician or engineer. Clicking on a colored area re-positions the video microscope over the object of interest for closer examination. A text entry window is available for logging additional comments.
Each inspection session produces a text log that details the location and description of each defect found. These logs are formatted for easy importation into a spreadsheet for further analysis.
The ASI inspection system applies client-defined rules to locate, identify, and log likely defects. These rules are maintained in the company’s central data file – a plain-text network file available to all inspection workstations. The structure of this file's content is tailored to the client's operation, making maximum possible use of the client's in-house nomenclature to ease the transition to automated inspection.
Sample setup data is provided so that the engineer can copy, paste, and modify proven data. The inspection system software provides extensive error reporting to aid the engineer in constructing and debugging this data, with prompt technical support provided by ASI.
ASI expects each application to be unique—the hardware and software can be configured to meet your custom applications.
Rapid Automated Modular Microscope (RAMM) System
The RAMM system's modular design allows a custom system to be easily developed. The microscope is configurable with infinity-corrected optics, filter cubes, filterwheels, and detectors. Automated features include high-speed XY stages, piezo & motorized focusing, auto-focus, and a robotic specimen loader. The system provides a solid platform, and has been designed for flexible cost-effective OEM development using high quality high MTBF components to reduce cost and increase customer satisfaction.
Ultra Precise Piezo Z focusing XYZ Stage
The PZ-2000 series stages from ASI have been specifically designed to provide a high resolution, and highly repeatable, means of controlling the X, Y, and Z position of the microscope stage. The XY axes derive their precise control through the use of closed-loop DC servomotors employing high-resolution encoders for positioning feedback. The XY stage provides resolutions down to 2.5 nm with repeatability factors down to 20 nm. The top plate of the stage accepts standard K-size slide inserts that are available for nearly any sample. The slide insert is moved in the Z-axis via piezo elements with ranges of 150 um, 300 um & 500 um available. The piezos utilize strain gauges mounted on the amplifiers to provide close loop control with nanometer accuracy. The piezo control electronics mount within the ASI controller and auto calibrate to provide extremely accurate positioning.
Ultra Stable Stages for Super Resolution Microscopy
ASI, a leader in ultra precise sub micron motion control, has developed ultra stable XY stages and imaging platforms for super resolution microscopy applications. Encoder resolutions of 2.5 nm with true optical resolutions of 10 nm at the sample are available. Systems are available for all standard research grade microscopes & OEM applications.
Flat-Top and Extended Travel Stages
ASI offers an assortment of stages with flat tops and extended range-of-travel for robotic loading. The MS-2500 stage provides 100 mm of Y-axis travel and 250 mm of X-axis travel, and works very well on existing inverted microscopes. Custom OEM configurations are available including front-loading stages with over 300 mm of Y-axis travel. All axes derive their precise control through the use of closed-loop DC servomotors employing high-resolution encoders for positioning feedback. The XY stage utilizes crossed-roller slides, precision lead-screws, and zero-backlash miniature geared DC servomotors for smooth and accurate motion. ASI stages come standard with rotary encoders with a resolution of 100 nm and bidirectional repeatability better than 700 nm rms. Resolutions down to 20 nm and repeatability accuracies of less 300 nm rms can be obtained with optional linear encoders. Compact table-top and OEM board-level controllers accept industry standard commands, provide automatic backlash correction, and allow RS-232 and USB communication with a host computer.
Focusing Translation Platform for Fixed Stage Microscopes
The FTP-2000 Focusing Translation Platform has been specifically designed to provide a high resolution, and highly repeatable, means of controlling the X, Y and Z position of the stage. The unit is ideal for use with fixed stage microscopes, or any application where ultra precise XYZ positioning is required. All axes derive their precise control through the use of closed-loop DC servomotors employing high-resolution rotary encoders for positioning feedback. The FTP-2000 stage utilizes crossed-roller slides, a high-precision lead screw, and zero-backlash miniature geared DC servomotors for smooth and accurate motion. The microprocessor-controlled MS-2000 control unit provides for RS-232 and USB communication with a host computer.
Stereoscope Automation
Based on ASI’s proven DC servomotor technology, the SZ-2000 automates stereoscopic microscopes. The unit can automate focus, zoom, and filter controls and can even incorporate a motorized XY stage on the base, as applicable. Precision gearing provides smooth operation of the control functions, while precision DC servomotors with a built-in rotary encoders keep track of positioning for error-free operation. An optional pair of footswitches permits hands-free operation of any axis, featuring an increment mode that changes to continuous motion after the switch has been held down for a second.
High-Speed Low-Vibration Filter Wheel
ASI's FW-1000 filterwheel utilizes a closed-loop DC servomotor to provide high speed and low vibration operation. The unit employs a high-resolution rotary encoder for positional feedback and utilizes memory to store programmable filter sequences and delays. Motion can be triggered by a TTL input pulse, as well as, standard RS232 commands. Wheels are available to hold eight 25 mm, or six 32mm, filters, and multiple wheels can be controlled from a single controller. The unit offers cycle times of 6 moves a second and has MTBF of over 100 million cycles; the lifetime test unit is currently at 125 million cycles & is still going strong.
CRIFF Continuous Reflective Interface Focus Feedback System
The CRIFF substantially eliminates focus drift in high power microscopy. Minute changes between the objective lens and the specimen's cover slip are sensed using a laser-based optical detector that provides a feedback signal to any of ASI’s Z-drive focus controllers. The CRIFF system provides high level focus stability allowing a specimen to remain accurately focused for hours at a time with less than 50 nanometers of drift caused by temperature or mechanical variations. The CRIFF module fits on the camera port of most microscopes
Modular Infinity Microscope
ASI's modular microscope system offers a flexible solution for specialized applications. Major components are connected together with a universal mating ring which provides accurate alignment with rotational flexibility.
Basic Components:
• Infinity Space Beam Splitter Cube – can be used for Epi-fluorescence filter cube or as right-angle objective adapter.
• Objective Adapter – options for Nikon CFI60, Mitutoyo, or Olympus RMS thread objectives.
• Universal Coupling – used on all infinity-space components for design flexibility.
Optional Components:
• C-mount Beam Splitter – provides a second camera / detector port.
• Filter Wheel Adapter – use with ASI FW1000 filter wheel. |
| Cutting edge technology for ultra precise motion control & super resolution microscopy
Rapid Automated Modular Microscope (RAMM) System
The RAMM system's modular design allows a custom system to be easily developed. The microscope is configurable with infinity-corrected optics, filter cubes, filterwheels, and detectors. Automated features include high-speed XY stages, piezo & motorized focusing, auto-focus, and a robotic specimen loader. The system provides a solid platform, and has been designed for flexible cost-effective OEM development using high quality high MTBF components to reduce cost and increase customer satisfaction.
Ultra Precise Piezo Z focusing XYZ Stage
The PZ-2000 series stages from ASI have been specifically designed to provide a high resolution, and highly repeatable, means of controlling the X, Y, and Z position of the microscope stage. The XY axes derive their precise control through the use of closed-loop DC servomotors employing high-resolution encoders for positioning feedback. The XY stage provides resolutions down to 2.5 nm with repeatability factors down to 20 nm. The top plate of the stage accepts standard K-size slide inserts that are available for nearly any sample. The slide insert is moved in the Z-axis via piezo elements with ranges of 150 um, 300 um & 500 um available. The piezos utilize strain gauges mounted on the amplifiers to provide close loop control with nanometer accuracy. The piezo control electronics mount within the ASI controller and auto calibrate to provide extremely accurate positioning.
Ultra Stable Stages for Super Resolution Microscopy
ASI, a leader in ultra precise sub micron motion control, has developed ultra stable XY stages and imaging platforms for super resolution microscopy applications. Encoder resolutions of 2.5 nm with true optical resolutions of 10 nm at the sample are available. Systems are available for all standard research grade microscopes & OEM applications.
Flat-Top and Extended Travel Stages
ASI offers an assortment of stages with flat tops and extended range-of-travel for robotic loading. The MS-2500 stage provides 100 mm of Y-axis travel and 250 mm of X-axis travel, and works very well on existing inverted microscopes. Custom OEM configurations are available including front-loading stages with over 300 mm of Y-axis travel. All axes derive their precise control through the use of closed-loop DC servomotors employing high-resolution encoders for positioning feedback. The XY stage utilizes crossed-roller slides, precision lead-screws, and zero-backlash miniature geared DC servomotors for smooth and accurate motion. ASI stages come standard with rotary encoders with a resolution of 100 nm and bidirectional repeatability better than 700 nm rms. Resolutions down to 20 nm and repeatability accuracies of less 300 nm rms can be obtained with optional linear encoders. Compact table-top and OEM board-level controllers accept industry standard commands, provide automatic backlash correction, and allow RS-232 and USB communication with a host computer.
Focusing Translation Platform for Fixed Stage Microscopes
The FTP-2000 Focusing Translation Platform has been specifically designed to provide a high resolution, and highly repeatable, means of controlling the X, Y and Z position of the stage. The unit is ideal for use with fixed stage microscopes, or any application where ultra precise XYZ positioning is required. All axes derive their precise control through the use of closed-loop DC servomotors employing high-resolution rotary encoders for positioning feedback. The FTP-2000 stage utilizes crossed-roller slides, a high-precision lead screw, and zero-backlash miniature geared DC servomotors for smooth and accurate motion. The microprocessor-controlled MS-2000 control unit provides for RS-232 and USB communication with a host computer.
Stereoscope Automation
Based on ASI’s proven DC servomotor technology, the SZ-2000 automates stereoscopic microscopes. The unit can automate focus, zoom, and filter controls and can even incorporate a motorized XY stage on the base, as applicable. Precision gearing provides smooth operation of the control functions, while precision DC servomotors with a built-in rotary encoders keep track of positioning for error-free operation. An optional pair of footswitches permits hands-free operation of any axis, featuring an increment mode that changes to continuous motion after the switch has been held down for a second.
Low Mass precision XY Stage
ASI's MS-2000-LM Low Mass stage retains the precision of our regular compact stage while providing increased thermal response times with 3/4 the mass. This small footprint stage measures 200 x 200 x 26 mm, and has 100 x 100 mm of XY travel with 100 nm resolution and 800 nm RMS repeatability. The unit can be configured to OEM specifications and provides a reliable XY motion control platform for drug discovery.
High-Speed Low-Vibration Filter Wheel
ASI's FW-1000 filterwheel utilizes a closed-loop DC servomotor to provide high speed and low vibration operation. The unit employs a high-resolution rotary encoder for positional feedback and utilizes memory to store programmable filter sequences and delays. Motion can be triggered by a TTL input pulse, as well as, standard RS232 commands. Wheels are available to hold eight 25 mm, or six 32mm, filters, and multiple wheels can be controlled from a single controller. The unit offers cycle times of 6 moves a second and has MTBF of over 100 million cycles; the lifetime test unit is currently at 125 million cycles & is still going strong.
CRIFF Continuous Reflective Interface Focus Feedback System
The CRIFF substantially eliminates focus drift in high power microscopy. Minute changes between the objective lens and the specimen's cover slip are sensed using a laser-based optical detector that provides a feedback signal to any of ASI’s Z-drive focus controllers. The CRIFF system provides high level focus stability allowing a specimen to remain accurately focused for hours at a time with less than 50 nanometers of drift caused by temperature or mechanical variations. The CRIFF module fits on the camera port of most microscopes
Ultra Precise Piezo-Z Focusing on select OEM Stages
If you do not require automated XY movement, but do require automated Z-axis positioning for acquiring precise Z-axis stacks, etc., then the PZM-2000 is your solution. The PZM-2000 stage retrofit provides a high resolution means of controlling the Z position of an manual OEM microscope stage. The Z-axis is driven by piezo elements incorporated directly in the top plate, and provides nanometer resolution and accuracy within its range of 100 µm. The piezo controller can be manually controlled with a ten-turn potentiometer, or remotely with a 0-10 volt D.C. analog input voltage. The piezo top plate accepts standard K-size slide inserts that are available for any sample, i.e., slides, petrie dishes, multi-well plates, etc. By moving the sample in the Z-plane, any objective can be used, eliminating twisting wires or needed spacers required when a piezo element is put onto a single objective.
Modular Infinity Microscope
ASI's modular microscope system offers a flexible solution for specialized applications. Major components are connected together with a universal mating ring which provides accurate alignment with rotational flexibility.
Basic Components:
• Infinity Space Beam Splitter Cube – can be used for Epi-fluorescence filter cube or as right-angle objective adapter.
• Objective Adapter – options for Nikon CFI60, Mitutoyo, or Olympus RMS thread objectives.
• Universal Coupling – used on all infinity-space components for design flexibility.
Optional Components:
• C-mount Beam Splitter – provides a second camera / detector port.
• Filter Wheel Adapter – use with ASI FW1000 filter wheel.
Thin-Film Inspection System
ASI’s automated thin-film inspection system uses ASI’s precision closed-loop DC servo motion control technology and video image analysis to optimize inspection. The goal is to optimize the productivity of human expert resources by offering relief from hours of tedious manual inspection. The system automatically flags potential defects like scratches and digs for expert re-inspection as needed. |
| Rapid Automated Modular Microscope (RAMM) System
The RAMM system’s modular design allows a custom system to be easily developed. The microscope is configurable with infinity-corrected optics, dichroic filter cubes, multi-wavelength excitation and emission filterwheels, and detectors including cameras and photomultipliers. A wide range of automated features can also be added these include: high-speed XY stages, precision piezo & motorized Z focusing, auto-focus, and a robotic specimen loader. The system provides a solid platform for high throughput screening, genetic sequencing, experimental research, and much more. It has been designed for flexible cost-effective OEM development using high quality high MTBF components to reduce cost and increase customer satisfaction.
ASI / Applied Scientific Instrumentation Eugene, OR 1-800-706-2284
www.ASIimaging.com |
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