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The Moscone Center
San Francisco, California, United States
28 January - 2 February 2017
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Translational Research Presentations

Tissue Optics, Laser-Tissue Interaction, and Tissue Engineering
(ordered by start date and time)


Development of a clinical grade photoacoustic transesophageal echocardiography system for continuous monitoring of mixed venous oxygen saturation
Paper 10494-15

Author(s):  Li, Massachusetts General Hospital (United States), et al.
Conference 10494: Photons Plus Ultrasound: Imaging and Sensing 2018
Session 3: Therapy Monitoring and Guidance II
Date and Time: Sunday, January 28, 2018, 1:30 PM

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Mixed venous oxygen saturation (SvO2) of pulmonary arteries is a gold-standard measure of the body’s hemodynamic stability. Traditionally, SvO2 monitoring requires placement of highly invasive pulmonary artery catheters (PAC). We are developing a low-risk PAC replacement, called photoacoustic transesophageal echocardiography (PA-TEE), which integrates transesophageal echocardiography with photoacoustic oximetry. We have constructed a clinical-grade PA-TEE system and tested it in living, human-sized swine in vivo. SvO2 traces produced by PA-TEE were found to correlate closely with simultaneously acquired PAC recordings. This study paves the way towards a first-in-human test of PA-TEE in the near future.


A novel drill design for photoacoustic guided surgeries
Paper 10494-18

Author(s):  Joshua, The Johns Hopkins Univ. (United States), et al.
Conference 10494: Photons Plus Ultrasound: Imaging and Sensing 2018
Session 3: Therapy Monitoring and Guidance II
Date and Time: Sunday, January 28, 2018, 2:15 PM

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Currently fluoroscopy is the imaging method of choice for guiding surgical drilling procedures. In addition to the harmful radiation dose to the patient and surgeon, fluoroscopy fails to visualize critical structures such as blood vessels and nerves. Photoacoustic imaging is well suited for visualizing these structures, but up until this point there was no system for delivering light to occluded drill bit tips. To address this, a prototype drill was designed, built, and tested using an internal light delivery system that allows laser energy to be transferred from a stationary laser source to the tip of a spinning drill bit.


Strain-photoacoustic imaging: an alternative approach for elasticity measurement
Paper 10496-38

Author(s):  Guan, Univ. of Michigan (United States), et al.
Conference 10496: Optical Elastography and Tissue Biomechanics V
Session 8: Elastography Methods and Applications
Date and Time: Sunday, January 28, 2018, 3:00 PM

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Elasticity is a biomarker of many diseases. The quantification of the elasticity as the ratio between strain and stress is difficult, as the stress in deep tissue cannot be directly measured. The collapsing of the vasculature could reflect the stress exerted on the surrounding tissue. The photoacoustic (PA) signals of the hemoglobin content within the vasculature could be an alternative measurement of the stress. This study investigated the estimation of the tissue elasticity using PA-US parallel imaging. Phantom and animal studies has shown that the ratio between the strain and the PA signal changes is highly correlated to the elasticity.


Photoacoustic needle biopsy for prostate cancer diagnosis in human prostates ex vivo and mice in vivo
Paper 10494-25

Author(s):  Guan, Univ. of Michigan (United States), et al.
Conference 10494: Photons Plus Ultrasound: Imaging and Sensing 2018
Session 4: Preclinical Imaging
Date and Time: Sunday, January 28, 2018, 4:45 PM

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The standard transrectal ultrasound guided biopsy for prostate cancer (PCa) diagnosis has limited core efficiency and diagnostic accuracy. The determinant diagnostic factor of PCa is the architecture changes. In this study, PA signals were acquired in 10 ex vivo human prostates using a needle probe. The architectural changes quantified by photoacoustic physio-chemical analysis (PAPCA) showed a significant difference between the normal and cancerous regions in the prostates (p<0.005). Quantification of the architectural changes in vivo in a mouse model is under investigation. The preliminary test has shown a significant difference between the normal and cancerous mouse prostates ex vivo (p<0.005).


Strain-photoacoustic imaging: feasibility study in phantoms and an animal model in vivo
Paper 10494-118

Author(s):  Yunhao, Univ. of Michigan (United States), et al.
Conference 10494: Photons Plus Ultrasound: Imaging and Sensing 2018
Session PSun: Posters-Sunday
Date and Time: Sunday, January 28, 2018, 5:30 PM

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Elasticity has been recognized as a biomechanical marker of many diseases. Quantifying the elasticity in deep tissue is difficult, as the stress in deep tissue cannot be directly measured. The collapsing of the vasculature could reflect the stress exerted on the surrounding tissue. The photoacoustic (PA) signals of the hemoglobin content within the vasculature could be an alternative measurement of the stress. A Strong correlation has been found between the strain and the PA signal changes in a phantom study. The ratios between the strain and PA signals changes have shown a significant difference between the intestinal fibrosis and inflammation conditions in rats in vivo.


Kagome fiber-based ultrafast laser surgery probe with custom CaF2 miniaturized optics for rapid in vivo tissue dissection
Paper 10493-25

Author(s):  Kaushik, The Univ. of Texas at Austin (United States), et al.
Conference 10493: Dynamics and Fluctuations in Biomedical Photonics XV
Session 6: Clinical Imaging and Evaluation
Date and Time: Monday, January 29, 2018, 12:10 PM

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An endoscopic ultrafast laser scalpel consisting of a custom-designed, miniaturized CaF2 objective is developed to focus ultrashort laser pulses delivered through a large air core Kagome fiber to a 3.4 μm diffraction limited spot size across a 100×100 μm^2 FOV. The probe can deliver fluences >8.0 J/cm^2 with negligible three-photon absorption in the CaF2 crystal lens pair, achieving material removal rates >0.5 mm^3/min. We will demonstrate the first usage of a handheld ultrafast laser probe in in vivo tissue removal experiments using a live hamster cheek pouch model and present a recently designed injection-molded enclosure towards clinical acceptance.


Characterization of intestinal fibrosis and inflammation with transcutaneous spectroscopic PA imaging
Paper 10494-55

Author(s):  Yunhao, Univ. of Michigan (United States), et al.
Conference 10494: Photons Plus Ultrasound: Imaging and Sensing 2018
Session 8: Functional Imaging and Brain Imaging
Date and Time: Monday, January 29, 2018, 4:45 PM

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The pathology of Crohn’s disease is characterized by obstructing intestinal strictures due to inflammation (with high levels of hemoglobin), fibrosis (with high levels of collagen), or a combination of both. The accurate characterization of the intestinal strictures is critical, as the fibrotic strictures have to be removed surgically. Combining the optical spectroscopy and ultrasound (US) imaging, photoacoustic (PA) imaging is an ideal tool for resolving the molecular components of the intestinal strictures. This study demonstrated that PA-US parallel imaging is capable of differentiating the fibrotic and inflammatory intestinal strictures in a rat model in vivo.


Assessing the performance of quantitative image features on early stage prediction of treatment effectiveness for ovary cancer patients: a preliminary investigation
Paper 10495-19

Author(s):  Abolfazl, The Univ. of Oklahoma (United States), et al.
Conference 10495: Biophotonics and Immune Responses XIII
Session 4: Novel Detection Technology
Date and Time: Monday, January 29, 2018, 4:50 PM

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A model-based acoustic reconstruction algorithm for deep tissue clinical photoacoustic imaging of cancerous tissues labeled with contrast agents
Paper 10494-86

Author(s):  Idan, Stanford Univ. (United States), et al.
Conference 10494: Photons Plus Ultrasound: Imaging and Sensing 2018
Session 12: Molecular Imaging
Date and Time: Tuesday, January 30, 2018, 4:45 PM

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Photoacoustics is a promising modality for cancerous tissue imaging. Recently, our group has developed a photoacoustic and ultrasonic system that was used for imaging both fresh ex vivo pancreatic cancer samples as well as in vivo trans-rectal prostate imaging. To improve the quality of the images, presented here is a model-based acoustic reconstruction technique. Overcoming the limitations of the imaging system, this technique was capable of reconstructing high-quality photoacoustic images, allowing real-time visualization of contrast agents deep within tissue. This study demonstrates feasibility and potential of tumor-specific detection either intraoperatively or in routine imaging in the clinic.


Real-time in vivo imaging of human lymphatic system using an LED-based photoacoustic/ultrasound imaging system
Paper 10494-3

Author(s):  Mithun, PreXion Corp. (Netherlands), et al.
Conference 10494: Photons Plus Ultrasound: Imaging and Sensing 2018
Session 1: Clinical Applications
Date and Time: Sunday, January 28, 2018, 8:30 AM

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Non-invasive in vivo imaging of lymphatic system is of paramount importance for analysing the functions of lymphatic vessels, and for investigating their contribution to metastasis. Recently, we reported on the development of a multi-wavelength real-time LED-based photoacoustic/ultrasound system (AcousticX). In this work, for the first time, we demonstrate that AcousticX is capable of real-time imaging of human lymphatic system. Results demonstrate the capability of our system in imaging vascular and lymphatic system simultaneously, which in turn could potentially provide detailed information regarding the interconnected roles of lymphatic and vascular system in diseases and foster the growth of therapeutic interventions.


Non-invasive measurement of blood flow with diffuse speckle statistics
Paper 10493-1

Author(s):  Turgut, ICFO - Instituto de Ciencias Fotónicas (Spain), et al.
Conference 10493: Dynamics and Fluctuations in Biomedical Photonics XV
Session 1: Speckle Technologies
Date and Time: Sunday, January 28, 2018, 8:40 AM

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I will present the fundamentals of deep tissue, non-invasive measurement of blood flow using diffuse speckle statistics and provide examples of different technological examples alongside clinical applications. I will conclude with the latest developments in the field towards fast, time-resolved, portable, low-cost systems.


Real-time in vivo blood oxygenation measurements with an open-source software platform for translational photoacoustic research
Paper 10494-7

Author(s):  Thomas, Deutsches Krebsforschungszentrum (Germany), et al.
Conference 10494: Photons Plus Ultrasound: Imaging and Sensing 2018
Session 1: Clinical Applications
Date and Time: Sunday, January 28, 2018, 9:30 AM

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Photoacoustic (PA) systems based on clinical linear ultrasound arrays have become increasingly popular in translational PA research. Especially handheld linear probes can be applied to a variety of clinical use cases. However, most translational work is based on proprietary development and as such not accessible to the community. In this contribution, we present a hybrid PA and ultrasonic imaging system for translational research that is integrated in the open-source Medical Imaging Interaction Toolkit (MITK). Our software is highly extensible and provides direct control of the laser and the ultrasonic system. We present it as a starting point for translational research.


Four-dimensional optoacoustic temperature mapping in laser-induced thermotherapy
Paper 10494-12

Author(s):  Francisco Javier, Helmholtz Zentrum München GmbH (Germany), et al.
Conference 10494: Photons Plus Ultrasound: Imaging and Sensing 2018
Session 2: Therapy Monitoring and Guidance I
Date and Time: Sunday, January 28, 2018, 11:15 AM

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Laser-induced thermal therapies are employed for selective destruction of dysfunctional or diseased tissues. The clinical outcome of these interventions is largely determined by the spatio-temporal distribution of temperature in the treated region. Herein, we demonstrate fast volumetric temperature mapping based on real-time three-dimensional optoacoustic imaging of the treated region coupled with a thermal-diffusion-based model of heat distribution in tissues. The new method’s performanec is demonstrated in tissue-mimicking phantoms and laser ablation of mice post mortem.


Simultaneous ultrasound and photoacoustics based flow cytometry
Paper 10494-16

Author(s):  Vaskar, Ryerson Univ. (Canada), et al.
Conference 10494: Photons Plus Ultrasound: Imaging and Sensing 2018
Session 3: Therapy Monitoring and Guidance II
Date and Time: Sunday, January 28, 2018, 1:45 PM

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We have developed a flow cytometer based on the simultaneous detection of ultrasound (US) and photoacoustic (PA) waves from individual cells flowing in a microfluidic channel. Our high throughput microfluidic flow cytometer is capable of detecting and analyzing thousands of label-free individual cells. The unique characteristic frequency spectrum in the US backscatter and PA signals enable us to analyze the single cells to extract features such as size, morphology, and biomechanical and functional properties.


Comparison of methods for reconstructing the system of baroreflectory regulation of arterial pressure from noisy data
Paper 10493-43

Author(s):  Yurii, Kotel'nikov Institute of Radio Engineering and Electronics of RAS (Russian Federation), et al.
Conference 10493: Dynamics and Fluctuations in Biomedical Photonics XV
Session PSun: Posters-Sunday
Date and Time: Sunday, January 28, 2018, 5:30 PM

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An original approach for the reconstruction of parameters of periodic time-delayed feedback generators is compared with the well-known methods using the time series analysis of a model of baroreflectory regulation of arterial pressure in the presence of dynamical and measurnment noises. The proposed approach is based on the analysis of synchronous response of the slave system with respect to the signal of the studied system. This work was supported by the Russian Science Foundation (Grant 14-12-00291).


Spectroscopic photoacoustics for assessing ischemic kidney damage
Paper 10494-28

Author(s):  Elizabeth, Ryerson Univ. (Canada), et al.
Conference 10494: Photons Plus Ultrasound: Imaging and Sensing 2018
Session 4: Preclinical Imaging
Date and Time: Sunday, January 28, 2018, 5:30 PM

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Ischemic reperfusion injuries (IRIs) cause microvascular damage, leading to scarring and an increase of collagen in the tissue. IRI events were induced in mouse kidneys, which were saline perfused 53 days post-surgery. Each kidney was cut in half laterally, with one half being monitored by photoacoustics in the NIR and NIR II ranges while cellularized, and the other half being decellularized before monitoring. PA was able to differentiate damaged and undamaged kidneys when both cellularized and decellularized in the NIR range. Additionally, collagen rich spectra in the NIR II range were found only in the damaged kidney.


Monitoring circulating prostate tumor cells after tumor resection by in vivo flow cytometry
Paper 10495-7

Author(s):  Xunbin, Shanghai Jiao Tong Univ. (China), et al.
Conference 10495: Biophotonics and Immune Responses XIII
Session 2: In vivo Detection of Immune Response
Date and Time: Monday, January 29, 2018, 10:30 AM

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We have developed the “in vivo microscopy” to study the mechanisms that govern tumor cell spreading through the microenvironment in vivo in real-time confocal near-infrared fluorescence imaging. A recently developed “in vivo flow cytometer” and optical imaging are used to assess site-specific tumor cell spreading and the circulation kinetics of tumor cells. A real- time quantitative monitoring of circulating tumor cells by the in vivo flow cytometer will be useful to assess the effectiveness of the potential therapeutic interventions.


In-vivo assessment of microvascular functional dynamics by combination of cmOCT and wavelet transform
Paper 10493-24

Author(s):  Salvatore, Univ. of Dundee (United Kingdom), et al.
Conference 10493: Dynamics and Fluctuations in Biomedical Photonics XV
Session 6: Clinical Imaging and Evaluation
Date and Time: Monday, January 29, 2018, 11:50 AM

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The imaging of skin microcirculation allows monitoring cardiovascular health conditions. Several techniques have been developed for the evaluation of micro-vessels functionality and anatomical structure. Recently, correlation mapping optical coherence tomography (cmOCT) has been presented as a processing method for obtaining high-resolution images of the cutaneous micro-vessels. In this work, the combination of cmOCT with the wavelet transform spectral analysis revealed dynamic functional information from images of the human skin microcirculation, with spatial resolution at different tissue depths. The results indicate the potential application of cmOCT as non-invasive diagnostic tool to gain a complete functional and morphological overview of the microcirculation.


Novel liposomal cisplatin used in esophageal cancer treatment
Paper 10495-12

Author(s):  Yei-San, Taoyuan General Hospital (Taiwan), et al.
Conference 10495: Biophotonics and Immune Responses XIII
Session 3: Nano-immunotherapy
Date and Time: Monday, January 29, 2018, 1:55 PM

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Transrectal photoacoustic imaging for guidance of targeted prostate biopsies
Paper 10494-147

Author(s):  Miya, National Defense Medical College (Japan), et al.
Conference 10494: Photons Plus Ultrasound: Imaging and Sensing 2018
Session PMon: Posters-Monday
Date and Time: Monday, January 29, 2018, 5:30 PM

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We performed a prospective intervention trial to TRUS-merged-with-PA imaging guided targeted biopsy in order to reduce unnecessary repeated biopsy. We developed an original TRUS-type PA probe consisting of micro-convex array transducer with optical illumination system provided co-registered PA and ultrasound images and a puncture needle guide attachment for the original TRUS-type PA probe. We confirmed the intensity of PAI signal correctly represents the distribution of microvascularity. We also found specific PA signals for the targeting cancer detection. This research is partially supported by the Research on Development of New Medical Devices from Japan Agency for Medical Research and development, AMED.


Label-free counting of circulating cells by in vivo photoacoustic flow cytometry
Paper 10495-28

Author(s):  Xunbin, Shanghai Jiao Tong Univ. (China), et al.
Conference 10495: Biophotonics and Immune Responses XIII
Session PSun: Posters-Monday
Date and Time: Monday, January 29, 2018, 5:30 PM

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Circulating cells are very important in biology and medicine, e.g., circulating tumor cells (CTCs). We have developed an in vivo photoacoustic flow cytometry (PAFC) to monitor circulating cells in vivo. In order to effectively distinguish the targeting PA signals from background noise, we have used the algorithm of Wavelet denoising method to reduce the background noise. The in vivo flow cytometry (IVFC) has shown a great potential for detecting circulating cells quantitatively in the blood stream.


Improving label-free detection of circulating melanoma cells by photoacoustic flow cytometry
Paper 10495-29

Author(s):  Xunbin, Shanghai Jiao Tong Univ. (China), et al.
Conference 10495: Biophotonics and Immune Responses XIII
Session PSun: Posters-Monday
Date and Time: Monday, January 29, 2018, 5:30 PM

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Melanoma is a malignant tumor of melanocytes. Circulating melanoma cell has high light absorption due to melanin highly contained in melanoma cells. This property is employed for the detection of circulating melanoma cell by in vivo photoacoustic flow cytometry (PAFC). PAFC is based on photoacoustic effect. By counting circulating melanoma cells termly, we obtained the number variation of circulating melanoma cells as melanoma metastasized.


Novel LCP combination therapy using HIF-1α and EGFR gene knockdown in oral cancer treatment
Paper 10495-37

Author(s):  Jyun Sian, Chung Yuan Christian Univ. (Taiwan), et al.
Conference 10495: Biophotonics and Immune Responses XIII
Session PSun: Posters-Monday
Date and Time: Monday, January 29, 2018, 5:30 PM

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Monitoring of tissue heating with medium intensity focused ultrasound via four dimensional optoacoustic tomography
Paper 10494-192

Author(s):  Francisco Javier, Helmholtz Zentrum München GmbH (Germany), et al.
Conference 10494: Photons Plus Ultrasound: Imaging and Sensing 2018
Session PTue: Posters-Tuesday
Date and Time: Tuesday, January 30, 2018, 6:00 PM

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Medium intensity focused ultrasound (MIFU) is aimed at stimulating physiological mechanisms to reinforce healing responses without reaching temperatures causing permanent tissue damage. The therapeutic outcome is strongly affected by the temperature distribution in the treated region, thus accurate temperature monitoring represents an important clinical need. We show that volumetric temperature maps can be rendered in real time with four-dimensional optoacoustic tomography. This allows for dynamic monitoring of the treated region, estimation of the peak temperature and the size of the heat-affected volume. The accurate performance of the suggested approach is showcased in experiments involving tissue-mimicking phantoms and bovine muscle sample.


Noninvasive measurement of cerebral venous oxygenation in neonates with a multi-wavelength, fiber-coupled laser diode optoacoustic system
Paper 10494-9

Author(s):  Stephen, The Univ. of Texas Medical Branch (United States), et al.
Conference 10494: Photons Plus Ultrasound: Imaging and Sensing 2018
Session 1: Clinical Applications
Date and Time: Sunday, January 28, 2018, 10:00 AM

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Noninvasive measurement of neonatal cerebral venous oxygenation could provide critical information on cerebral hypoxia. By probing the superior sagittal sinus (SSS), a large central cerebral vein, we can measure oxygenation with our multi-wavelength, fiber-coupled laser-diode optoacoustic system. SSS oxygenation was measured in reflection mode through open anterior and posterior fontanelles without obscuration by the overlying calvarium. In transmission mode it was measured through the skull in the occipital area. We monitored the SSS oxygenation in neonates with varying gestation, birth weight and clinical histories to identify normal range and difference between neonates with and without risk factors for cerebral hypoxia.


In-vivo three-dimensional optoacoustic molecular imaging of the synovial vasculature in a mouse model of knee joint osteoarthritis
Paper 10494-20

Author(s):  Zhongyu, The Third Affiliated Hospital, Sun Yat-Sen Univ. (China), et al.
Conference 10494: Photons Plus Ultrasound: Imaging and Sensing 2018
Session 4: Preclinical Imaging
Date and Time: Sunday, January 28, 2018, 3:15 PM

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Synovitis is a driver of osteoarthritis. Imaging of the synovial vasculature is essential for osteoarthritis assessment, while traditional imaging techniques have limitations. In this study, the knee joints of live mice were evaluated with 3D ultrasonography, including B mode, Power Doppler (PD) and optoacoustic imaging (OA). We found that OA could demonstrate the structure of synovial vasculature during knee osteoarthritis progression. Quantitative OA vascular density was consistent with uCT-based angiography and histological findings. Meanwhile, OA could also evaluate the function of the synovial vasculature by measuring blood oxygen saturation (sO2). Quantitative OA sO2 was found negatively correlated with histological cartilage damage.


Noninvasive optoacoustic monitoring of cerebral venous blood oxygenation in humans: Validation with invasive measurements
Paper 10494-54

Author(s):  Yuriy, The Univ. of Texas Medical Branch (United States), et al.
Conference 10494: Photons Plus Ultrasound: Imaging and Sensing 2018
Session 8: Functional Imaging and Brain Imaging
Date and Time: Monday, January 29, 2018, 4:30 PM

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Management of TBI patients requires cerebral venous oxygenation measurements, currently by invasive techniques. Recently we developed transmission-mode optoacoustic systems for this application by probing the superior sagittal sinus (SSS), a large central cerebral vein. In this study we validated our optoacoustic SSS oxygenation measurements in adult TBI patients using invasive measurements with jugular bulb catheters. Multi-wavelength optoacoustic systems operating in the NIR spectral range were used for measurements. The obtained results demonstrated high correlation of the noninvasive, optoacoustic SSS oxygenation measurements with the invasive measurements. Bland-Altman analysis yielded clinically acceptable bias and standard deviation of -2.7% and 3.5%, respectively.


A fast MEMS scanning photoacoustic microscopy system and its application in glioma study
Paper 10494-88

Author(s):  Renzhe, Singapore Bioimaging Consortium (Singapore), et al.
Conference 10494: Photons Plus Ultrasound: Imaging and Sensing 2018
Session 13: Microscopy
Date and Time: Wednesday, January 31, 2018, 8:00 AM

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We present a MEMS based scanning photoacoustic microscopy (PAM) system and its application in glioma mouse model study. Our PAM system has high optical resolution (~2.5 μm) and high scanning speed (up to 50 kHz), which is ideal for cerebral vascular imaging. In this study, the mice with glioma are treated with vascular disrupting agent (VDA). Our PAM system is utilized to image the cerebral with the whole skull intact before and after the injection of VDA. By image registration, the response of every single blood vessel can be traced. This will provide us deeper understanding of the drug effect.


Precise and controlled tissue cutting using (photo-)mechanical 'energy': comparison of a pulsed Erbium laser with a new pulsed water jet
Paper 10492-10

Author(s):  Rudolf M. , Vrije Univ. Medical Ctr. (Netherlands), et al.
Conference 10492: Optical Interactions with Tissue and Cells XXIX
Session 3: Photomechanical Effects
Date and Time: Monday, January 29, 2018, 1:30 PM

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The mechanism of tissue cutting was compared between a pulsed Erbium laser and a pulsed water jet using special thermal and high speed imaging setups. Short laser pulses rupture tissue by explosive vaporization, while high speed pulsed water jet cleave tissue with pure mechanical force partly due to imploding cavitation bubbles leaving elastic structures like (micro)vessels intact. The depth of the cut in tissue could be controlled precisely with the 'energy' setting from 1-10 mm independent of scanning speed for the water jet. The pulsed water jet shows to have great potential for precision surgery without any thermal effects.


Fluence-matching method based on photoacoustic radiofrequency spectraTR
Paper 10494-48

Author(s):  Muhannad N. , Ryerson Univ. (Canada), et al.
Conference 10494: Photons Plus Ultrasound: Imaging and Sensing 2018
Session 7: Quantitative Imaging
Date and Time: Monday, January 29, 2018, 2:30 PM

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Extracting information from the photoacoustic radiofrequency spectral slope can be used to improve chromophore quantification for better oxygenation estimates. The spectral slope has been shown to carry information related to the photoacoustic absorbers’ size and the light distribution. In multi-wavelength photoacoustic imaging, the absorbers size remains unchanged; this allows the direct association between the spectral slope and light distribution. An ultrasound frequency filter was designed using the measured spectral slopes and applied to match the fluence profiles for the image wavelengths used. The results demonstrate a significant reduction in the influence of light distribution on the measured oxygenation values.


Novel 3D printing technology for direct fabrication of tissue-mimicking phantoms
Paper 10494-74

Author(s):  Daniil I. , Univ. College London (United Kingdom), et al.
Conference 10494: Photons Plus Ultrasound: Imaging and Sensing 2018
Session 11: Phantoms and Standards for Photoacoustic Imaging
Date and Time: Tuesday, January 30, 2018, 1:30 PM

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Tissue-mimicking anatomical phantoms are vital for evaluation of imaging system performance, calibration of medical devices, and training medical staff in techniques such as ultrasonography. Three-dimensional (3D) printing technology allows direct formation of the object and provides freedom in design. Unfortunately, commercially available 3D printing materials don’t have suitable physical properties to mimick tissue. In this work, we developed a novel 3D printer based on Gel Wax. This tissue-mimicking material is soft, optically and acoustically clear and does not dehydrate. The optical and acoustic properties of the material can be tailored. We demonstrate hippocampus models directly printed using our proposed technology.


Novel realistic tissue-mimicking prostate cancer phantom for the diagnostic and training
Paper 10494-219

Author(s):  Daniil I. , Univ. College London (United Kingdom), et al.
Conference 10494: Photons Plus Ultrasound: Imaging and Sensing 2018
Session PTue: Posters-Tuesday
Date and Time: Tuesday, January 30, 2018, 6:00 PM

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The performance and accuracy of ultrasound-MRI novel fusion systems need to be validated accurately for different types of tumour tissue properties and geometries. This validation process would require time and ethics approval if animals or patients were used. In this work, we developed a novel tissue-mimicking prostate phantom to assess the accuracy of fusion systems. The tumour anatomy is segmented from MRI data set using segmentation tools. The realistic phantom is made of novel materials that simulate different cancer tissues visible on ultrasound and MRI. A three-dimensional printing technique facilitates the fabrication of the anatomically accurate prostate model.


Optical coherence tomography based angiography: principles and applications
Paper 10493-10

Author(s):  Ruikang K. , Univ. of Washington (United States), et al.
Conference 10493: Dynamics and Fluctuations in Biomedical Photonics XV
Session 3: Keynote Session
Date and Time: Sunday, January 28, 2018, 2:00 PM

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We will present the principles of optical coherence tomography based angiography, more specifically optical microangiography (OMAG), and its preclinical and clinical applications to delineate the dynamic blood perfusion, down to capillary level resolution, within living tissues, including cerebral blood flow in rodent models, retinal vessel networks and subcutaneous skin microcirculation in humans.


Photoacoustic microscopy enables multilayered histological imaging of human breast cancer without staining
Paper 10494-140

Author(s):  Terence T. W. , Washington Univ. in St. Louis (United States), et al.
Conference 10494: Photons Plus Ultrasound: Imaging and Sensing 2018
Session PMon: Posters-Monday
Date and Time: Monday, January 29, 2018, 5:30 PM

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Currently no intraoperative tools can microscopically analyze an entire lumpectomy specimen, which results in 20–60% of patients undergoing second surgeries to obtain clear margins. To address this critical need, we demonstrate that by taking advantage of the intrinsic optical contrast of breast tissue, photoacoustic microscopy (PAM) can provide multilayered histology-like imaging of the tissue surface and subsurface. PAM does not require tissue processing or staining, and it can be performed promptly and intraoperatively, enabling immediate directed re-excision and reducing the number of second surgeries.


In vivo low-cost photoacoustic imaging using LED light source and clinical ultrasound scanner
Paper 10494-177

Author(s):  Haichong K. , Johns Hopkins Univ. (United States), et al.
Conference 10494: Photons Plus Ultrasound: Imaging and Sensing 2018
Session PMon: Posters-Monday
Date and Time: Monday, January 29, 2018, 5:30 PM

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The accessibility of photoacoustic (PA) imaging is limited because of specific hardware requirements including channel data acquisition and high-power pulsed laser. To broaden the impact of clinical PA imaging, we propose a vendor-independent PA imaging system utilizing ultrasound post-beamformed radio frequency data, which is readily accessible in some clinical scanners. Also, light emitting diodes (LED) was used as a low-energy high pulse repetition frequency light source to replace conventional high energy laser. The resulted PA images showed a comparable image quality compared to conventional delay-and-sum beamforming, and it reaffirms the potential of the proposed low-cost PA imaging system for clinical application.


Design and simulation of a wearable system for the multimodal imaging of breast abnormalities
Paper 10494-185

Author(s):  David M. , Stanford Univ. School of Medicine (United States), et al.
Conference 10494: Photons Plus Ultrasound: Imaging and Sensing 2018
Session PTue: Posters-Tuesday
Date and Time: Tuesday, January 30, 2018, 6:00 PM

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There is a significant need and potential benefit in improving on current breast cancer screening methods. Photoacoustic imaging has emerged as a promising technique to diagnose breast tumors. In addition, wearable detection systems can improve early detection, cost and patient compliance. Here, we present the design and in silico simulation of a wearable photoacoustic system for early detection of breast tissue abnormalities. The findings analyze the advantage of more frequent imaging in early cancer detection. In addition, an optimized design and sampling rate is demonstrated.


Important Dates

Abstracts Due
17 July 2017

Author Notification
25 September 2017

Manuscripts Due
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Journal of Biomedical Optics

Journal of Biomedical OpticsPublishes peer-reviewed papers that utilize modern optical technology for improved health care and biomedical research.