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The Moscone Center
San Francisco, California, United States
28 January - 2 February 2017
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Translational Research Presentations

Nano/Biophotonics BiOS Program Track, LASE, and OPTO
(ordered by start date and time)


Whispering-gallery-mode resonators: from a novel sensing mechanism to a wireless sensing system
Paper 10510-5

Author(s):  Weijian, Washington Univ. in St Louis (United States), et al.
Conference 10510: Frontiers in Biological Detection: From Nanosensors to Systems X
Session 1: Resonators and Interferometry
Date and Time: Sunday, January 28, 2018, 2:50 PM

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In this talk, I will discuss our recent work on a novel sensing mechanism to enhance the sensitivity of whispering-gallery-mode sensors. Owing to the complex-square-root topology near an exceptional point, whispering-gallery-mode resonators operating at exceptional points are demonstrated to exhibit higher sensitivity than conventional resonator sensors for sufficiently small perturbations. I will also talk about a miniature whispering-gallery-mode sensing system with a wireless interface fully controlled by a customized iOS app for thermal sensing. Our studies will help broaden the applications of whispering-gallery-mode sensors.


A non-invasive system to assess tissue temperature distribution
Paper 10510-9

Author(s):  Sahar, Massachusetts General Hospital (United States), et al.
Conference 10510: Frontiers in Biological Detection: From Nanosensors to Systems X
Session 2: Magnetic Sensing and New Platforms
Date and Time: Sunday, January 28, 2018, 5:00 PM

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In many applications such as fractional ablative laser treatments, pain control, and fat removal, it is crucial to determine the temperature distribution across different layers of the tissue. We present a hybrid model consisting of point-wise temperature measurements and mathematical modeling of the simultaneous conduction and phase-change heat transfer to determine the coupling between the surface temperature and the isotherm planes across the tissue. The high accuracy and reliability, low sensitivity to variations in tissue texture and structure, simple design and implementation, as well as non-invasive nature of the method employed make the new system a robust tool in monitoring the temperature distribution and controlling the cooling or heating rate. The new system significantly increases the efficacy, safety, and reliability of the tissue thermal management treatments and reduces the risk of damage to non-target tissues especially for aggressive treatments.


Near infrared photoimmunotherapy for cancer: progresses on pre-clinical and clinical studies
Paper 10508-1

Author(s):  Hisataka, National Cancer Institute (United States), et al.
Conference 10508: Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications X
Session 1: Theranostics and NIR Fluorescence Imaging Strategies
Date and Time: Monday, January 29, 2018, 8:20 AM

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Near infrared photoimmunotherapy (NIR-PIT) is a new type of molecularly-targeted cancer photo-therapy, which employs a NIR silica-phthalocyanine, IR700, conjugated to a monoclonal antibody targeting cell-surface molecules. There are a lot progresses on pre-clinical and translational works. NIR-PIT targeting EGFR using the cetuximab-IR700 conjugate is now on the phase 2 clinical trial against late-stage head and neck squamous cell cancer patients with great success. I will give a current update of both pre-clinical and translational researches, and also on-going clinical trials and some of their results of NIR-PIT for cancer.


Evaluations of cell uptake capabilities of gold nanoparticle and photosensitizer in a cell spheroid
Paper 10507-27

Author(s):  Po-Hao, National Taiwan Univ. (Taiwan), et al.
Conference 10507: Colloidal Nanoparticles for Biomedical Applications XIII
Session 8: Biofunctionalization and Cellular Uptake of Nanoparticles
Date and Time: Sunday, January 28, 2018, 4:40 PM

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The cell uptake behaviors in cell spheroids are investigated. In particular, the penetration depths of Au nanoring, Au nanorod, and photosensitizer in cell spheroids are evaluated based on a proposed technique of using confocal fluorescent microscopy. By using a geometric computation process, we can estimate the width of a fluorescent belt region, which corresponds to the uptake depth. Based on such evaluations, we can understand whether the quiescent viable cells in the middle layer of a cell spheroid. Also, by using a cell culture insert, we can estimate the uptake Au nanoparticle number per cell through mass spectrometry measurement.


Effects of Au nanoring and photosensitizer exocytosis from cancer cells on their damage efficiency through photodynamic and photothermal processes
Paper 10507-34

Author(s):  Yulu, National Taiwan Univ. (Taiwan), et al.
Conference 10507: Colloidal Nanoparticles for Biomedical Applications XIII
Session 10: Applications of Nanoparticles in Cancer Theranostics I
Date and Time: Monday, January 29, 2018, 11:40 AM

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We investigate the dependencies of cell damage efficiency, gold nanoring (NRI) and photosensitizer amounts stayed in cells on the delay time. In particular, we differentiate the two possible escape pathways of the photosensitizer, AlPcS, i.e., AlPcS escape alone after its linkage with Au NRI is broken and AlPcS escape together with the linked Au NRI. Also, we intend to understand the dependence of the aforementioned AlPcS escape pathway on the location of Au NRIs inside a cell after they are taken up. The result indicates that the photosensitizer is more stable when it is linked with an Au NP.


Fusogenic microbubble-porphysome conjugates as a novel dual-modality ultrasound/photoacoustic theranostic agent
Paper 10507-37

Author(s):  Pradyumna, Univ. of Alberta (Canada), et al.
Conference 10507: Colloidal Nanoparticles for Biomedical Applications XIII
Session 11: Applications of Nanoparticles in Cancer Theranostics II
Date and Time: Monday, January 29, 2018, 2:20 PM

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We have developed a novel dual modality ultrasound and photoacoustic theranostic agent composed of multiple porphyrin-lipid containing nanoscale liposomes conjugated to gas core microbubbles. The porphysome-microbubble constructs are produced through quick self-assembly and provide strong photoacoustic contrast with over 30dB increase in SNR. Furthermore, we are able to incorporate the fusion associated small transmembrane (FAST) proteins into the liposomal constructs to enhance liposomal payload delivery by avoiding lysosomal degradation prevalent in endocytic uptake pathways.


Breast cancer early detection via tracking of skin back-scattered secondary speckle patterns
Paper 10506-1

Author(s):  Aviya, Bar-Ilan Univ. (Israel), et al.
Conference 10506: Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV
Session 1: Nanoscale Imaging I
Date and Time: Tuesday, January 30, 2018, 1:00 PM

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Breast cancer has become a major cause of death among women. The lifetime risk of a woman developing this disease has been established as one in eight. The most useful way to reduce breast cancer death is to treat the disease as early as possible. The existing methods of early diagnostics of breast cancer mainly based on screening mammography periodically conducted at medical facilities, or MRI. The current work for the first time is evaluating possibility of simplified breast cancer detection by introducing artificial irregularities within the tissue under the skin of hen breast and detecting it by stimulating the skin by sound wave, illuminating it by laser beam and tracking the reflected secondary speckles with camera having special optics.


Peptidomimetic-based prostate-specific membrane antigen (PSMA) targeted fluorescent magnetic nanoparticles and surface enhanced Raman scattering (SERS) nanoparticles for liquid biopsy applications
Paper 10508-5

Author(s):  Pradyumna, Univ. of Alberta (Canada), et al.
Conference 10508: Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications X
Session 6: Nanoimaging Platforms
Date and Time: Tuesday, January 30, 2018, 2:30 PM

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We have developed a method of highly specific enrichment of circulating tumor cells (CTCs) in liquid biopsies. Using PSMA-targeting peptidomimetics decorating the surface of magnetic and surface enhanced Raman scattering (SERS) nanoparticles, we are able to measure the real-time magnetic trapping of CTCs. By multiplexing with different ‘flavors’ of SERS nanoparticles with or without targeting peptidomimetics, we are able to ratiometrically detect specific binding of nanoparticles to CTCs with a high degree of accuracy.


Gold nanoparticles for non-invasive cell tracking with CT imaging
Paper 10506-43

Author(s):  Rinat, Bar-Ilan Univ. (Israel), et al.
Conference 10506: Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV
Session PTue: Posters-Tuesday
Date and Time: Tuesday, January 30, 2018, 6:00 PM

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Cell-based therapy is the transplantation of living cells for the treatment of diseases and injuries. Such therapy offers a promising solution for the treatment of various pathologies that conventional medicine cannot cure effectively. A major obstacle in the advancement and implementation of cell therapy is the challenge of no-invasively tracking transplanted cells in the body. We developed a novel methodology for longitudinal and quantitative in vivo cell tracking, based on the combination of CT as an imaging modality and gold nanoparticles as labeling agents. By uniting the superior visualization abilities of classical CT with state-of-the-art nanotechnology we were able to achieve high-resolution cell tracking, which could be translated to the clinic.


Plasmonic eradication of malignant cells in a three dimensional culture
Paper 10522-6

Author(s):  Limor, Technion-Israel Institute of Technology (Israel), et al.
Conference 10522: Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVIII
Session 2: Ultrafast Laser Interaction with Cells and Tissues
Date and Time: Sunday, January 28, 2018, 11:10 AM

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We demonstrate plasmonic phototherapy in a three dimensional cell culture, using a natural hydrogel scaffold for growing breast cancer epithelial cells in co-culture with healthy fibroblasts. The malignant cells were specifically targeted using anti-EGFR-coated gold nanospheres, followed by washout of unbound particles and irradiation by amplified femtosecond pulses at 800 nm. Irradiated colonies seized to develop and grow; widespread death of both normal and malignant cells led to disintegration of the colonies. Pulse broadening experiments demonstrated similar cell death for pulses between 45 fs and 400 fs, while pulses longer than 500 fs had no visible effect on the cells.


Toxicological evaluation of Cd-based fluorescent nanoprobes by means of in vivo studies
Paper 10508-6

Author(s):  Patricia M. A. , Univ. Federal de Pernambuco (Brazil), et al.
Conference 10508: Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications X
Session 6: Nanoimaging Platforms
Date and Time: Tuesday, January 30, 2018, 2:10 PM

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Cadmium still represents a stigma for many research- and/or industrial applications. Some deleterious effects are attributed to Cadmium. In the present work, highly fluorescent Cadmium sulfide quantum dots are investigated by e.g. physical-chemical characterization. Most important however is their application as fluorescent probes for bio-imaging in living cells and tissues. This work presents their toxicological evaluation by means of in vivo studies. Bio-imaging experiments are performed without any pre-treatment. The toxicological studies performed, strongly indicate that the use of Cadmium based nanoparticles as fluorescent probes may be nonhazardous and not induce side effects for cells/tissues


Clinically translatable nanotheranostic platform for peripheral nerve regeneration: design with the outcome in mind
Paper 10508-7

Author(s):  Jelena M. , Duquesne Univ. (United States), et al.
Conference 10508: Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications X
Session 1: Theranostics and NIR Fluorescence Imaging Strategies
Date and Time: Monday, January 29, 2018, 8:50 AM

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Peripheral nerve injury (PNI) is a complex medical problem. PNI secondary to trauma, compression or iatrogenic causes can lead to functional motor and sensory disability. Neuroinflammation associated with PNI is a dynamic process that changes during the course of recovery and healing with extremely high interindividual variability. We present here the rationale, relevance and quality by design approach in development of a novel clinically translatable theranostic hydrogel platform to mimimize neuroinflammation and promote neuroregeneration after PNI. The proposed nanotheranostic is capable of a cell and PNI site-specific multidrug delivery, and could facilitate safe, economical, longitudinal, non-invasive monitoring of drug delivery.


Fluorescent nanoparticles for targeted detection of ovarian tumors for enhanced surgery
Paper 10507-35

Author(s):  Jacob M. , City of Hope Beckman Research Institute (United States), et al.
Conference 10507: Colloidal Nanoparticles for Biomedical Applications XIII
Session 11: Applications of Nanoparticles in Cancer Theranostics II
Date and Time: Monday, January 29, 2018, 1:40 PM

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Important Dates

Abstracts Due
17 July 2017

Author Notification
25 September 2017

Manuscripts Due
See Individual Conferences


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Journal of Biomedical Optics

Journal of Biomedical OpticsPublishes peer-reviewed papers that utilize modern optical technology for improved health care and biomedical research.