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2 - 7 February 2019
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2018 BiOS Hot Topics Session

Presentations From Ten Leading Researchers In Biophotonics

BiOS Hot Topics Session

Monitoring oxygen levels in premature infants; safely managing cancer rather than trying to cure it with toxins; producing a "super" biofuel from microorganisms; accessing tumors with new combinations of photodynamic therapy and radiation; and mapping brains on an industrial scale: the 2018 SPIE Photonics West Hot Topic session on Saturday, 27 January showcased ten leading biomedical researchers and their groundbreaking work.

"This whole enterprise is about helping people," said 2018 BiOS Symposium Chair and SPIE Fellow Dr. R. Rox Anderson as he opened the proceedings alongside co-chair and SPIE Fellow Dr. James Fujimoto. Dr. Anderson also noted the success of the BiOS conference, which this year featured a record 2,400 oral and poster presentations.

The first speaker, Dr. Tayyaba Hasan, looked future-forward with "Photodynamic Therapy: The Next 10 Years" Hasan's goal with PDT is to get chemistry to happen at the right place and time. Her presentation looked at using it as a complementary tool to assist other modalities and drugs to enable lower concentrations and toxicity in treatment.

University of Toronto professor and SPIE Fellow Dr. Brian Wilson also discussed new directions in PDT in his "Taking the Photonics Out of Photodynamic Therapy." "The real hot topic here," he said, "is the intersection of radiation medicine and photomedicine." His research focus includes the use of PDT in lung transplantation to disinfect the lung tissue pre-surgery.

Husband-and-wife team Drs. Katarina and Sune Svanberg of Lund University and South China Normal University, both SPIE Fellows, discussed applications of gas in scattering media absorption spectroscopy (GASMAS), including food monitoring and medical diagnostics - monitoring tissue degradation following hip replacements, and oxygen levels in neonatal and premature infants - and diagnosing ear infections using gas signals that occur behind the ear drum.

UCLA and University of Tokyo's Dr. Keisuke Goda, also an SPIE Fellow, with his "Large-scale Single-cell Analysis with Extreme Imaging" presentation, explored the benefits of utilizing different methods of high-speed imaging of the microalgal Englena, an organism with plant and animal characteristics that can be a high-yield source of biofuel.

Technical University Dresden's Dr. Julia Walther explored "Optical Coherence Tomography in the Oral Cavity," a detailed presentation on state-of-the-art, hard- and soft-tissue applications of OCT for dentistry.

SPIE Fellow Dr. Irene Georgakoudi of Tufts University, with "Optical, Label-free, Morpho-functional Metabolic Imaging," described her group's research into optical metabolic biomarkers utilizing two fluorophores that naturally fluoresce, NADH and FAD. Her team is exploring applications in drug discovery, drug safety, and treatment optimization.

University of California at Berkeley's Dr. Hillel Adesnik gave an overview of his group's work with a new multi-photon microscopy method for controlling neural activity in 3D called 3D-SHOT (scanless holographic optogenetics), already used to study the whisker maps that rodents create to navigate their surroundings.

SPIE Fellow Dr. Qingming Luo of the Britton Chance Center for Biomedical Photonics, Hauzhong University of Science and Technology and Director of the Wuhan National Laboratory for Optoelectronics, presented "Brainsmatics - Visualizing Brain-wide Networks," sharing his high-speed brain-imaging systems, which utilize an integrated, systematic approach to measuring, analyzing, managing, and displaying whole brain data.

Finally, Institut de Ciències Fotòniques' Dr. Turgut Durduran presented his "Latest on Noninvasive, Optical Blood Flow Measurements Breaking Cost, Portability and Scalability Limits," aiming for a multi-center, high-density, low-cost approach to diffuse correlation spectroscopy (DCS).

Facilitated by SPIE Fellow Dr. Sergio Fantini, the evening included several awards: the SPIE 2018 Technology Innovator Award to SPIE Fellow Dr. Elizabeth Hillman; the SPIE 2018 Britton Chance Biomedical Optics Award to Dr. Tayyaba Hasan; and inaugural SPIE-Franz Hillenkamp Postdoctoral Fellowships in Problem-Driven Biophotonics and Biomedical Optics to Dr. Haley Marks and Dr. Jan Philip Kolb.  

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