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Proceedings Paper

Advanced biohybrid materials based on nanoclays for biomedical applications
Author(s): Eduardo Ruiz-Hitzky; Margarita Darder; Bernd Wicklein; Francisco M. Fernandes; Fidel A. Castro-Smirnov; M. Angeles Martín del Burgo; Gustavo del Real; Pilar Aranda
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Paper Abstract

Bio-nanohybrids prepared by assembling natural polymers (polysaccharides, proteins, nucleic acids, etc) to nanosized silicates (nanoclays) and related solids (layered double hydroxides, LDHs) give rise to the so-called bionanocomposites constituting a group of biomaterials with potential applications in medicine. In this way, biopolymers, including chitosan, pectin, alginate, xanthan gum, ι-carrageenan, gelatin, zein, and DNA, as well as phospholipids such as phosphatidylcholine, have been incorporated in layered host matrices by means of ion-exchange mechanisms producing intercalation composites. Also bio-nanohybrids have been prepared by the assembly of diverse bio-polymers with sepiolite, a natural microfibrous magnesium silicate, in this case through interactions affecting the external surface of this silicate. The properties and applications of these resulting biomaterials as active phases of ion-sensors and biosensors, for potential uses as scaffolds for tissue engineering, drug delivery, and gene transfection systems, are introduced and discussed in this work. It is also considered the use of synthetic bionanocomposites as new substrates to immobilize microorganisms, as for instance to bind Influenza virus particles, allowing their application as effective low-cost vaccine adjuvants and carriers.

Paper Details

Date Published: 24 October 2012
PDF: 8 pages
Proc. SPIE 8548, Nanosystems in Engineering and Medicine, 85480D (24 October 2012); doi: 10.1117/12.999995
Show Author Affiliations
Eduardo Ruiz-Hitzky, Instituto de Ciencia de Materiales de Madrid (Spain)
Margarita Darder, Instituto de Ciencia de Materiales de Madrid (Spain)
Bernd Wicklein, Instituto de Ciencia de Materiales de Madrid (Spain)
Francisco M. Fernandes, Instituto de Ciencia de Materiales de Madrid (Spain)
Fidel A. Castro-Smirnov, Instituto de Ciencia de Materiales de Madrid (Spain)
M. Angeles Martín del Burgo, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Spain)
Gustavo del Real, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Spain)
Pilar Aranda, Instituto de Ciencia de Materiales de Madrid (Spain)


Published in SPIE Proceedings Vol. 8548:
Nanosystems in Engineering and Medicine
Sang H. Choi; Jin-Ho Choy; Uhn Lee; Vijay K. Varadan, Editor(s)

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