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Proceedings Paper

Anti-tumor response with immunologically modified carbon nanotubes and phototherapy
Author(s): Joseph T. Acquaviva; Feifan Zhou; Ellen Boarman; Wei R. Chen
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Paper Abstract

While successes of different cancer therapies have been achieved in various degrees a systemic immune response is needed to effectively treat late-stage, metastatic cancers, and to establish long-term tumor resistance in the patients. A novel method for combating metastatic cancers has been developed using immunologically modified carbon nanotubes in conjunction with phototherapy. Glycated chitosan (GC) is a potent immunological adjuvant capable of increasing host immune responses, including antigen presentation by activation of dendritic cells (DCs) and causing T cell proliferation. GC is also an effective surfactant for nanomaterials. By combining single-walled carbon nanotubes (SWNTs) and GC, immunologically modified carbon nanotubes (SWNT-GC) were constructed. The SWNT-GC suspension retains the enhanced light absorption properties in the near infrared (NIR) region and the ability to enter cells, which are characteristic of SWNTs. The SWNT-GC also retains the immunological properties of GC. Cellular SWNT-GC treatments increased macrophage activity, DC activation and T cell proliferation. When cellular SWNT-GC was irradiated with a laser of an appropriate wavelength, these immune activities could be enhanced. The combination of laser irradiation and SWNT-GC induced cellular toxicity in targeted tumor cells, leading to a systemic antitumor response. Immunologically modified carbon nanotubes in conjunction with phototherapy is a novel and promising method to produce a systemic immune response for the treatment of metastatic cancers.

Paper Details

Date Published: 21 February 2013
PDF: 8 pages
Proc. SPIE 8582, Biophotonics and Immune Responses VIII, 85820L (21 February 2013); doi: 10.1117/12.999993
Show Author Affiliations
Joseph T. Acquaviva, Univ. of Central Oklahoma (United States)
Feifan Zhou, South China Normal Univ. (China)
Ellen Boarman, Univ. of Central Oklahoma (United States)
Wei R. Chen, Univ. of Central Oklahoma (United States)

Published in SPIE Proceedings Vol. 8582:
Biophotonics and Immune Responses VIII
Wei R. Chen, Editor(s)

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