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Proceedings Paper

Nonlinear optical imaging characteristics of colonic adenocarcinoma using multiphoton microscopy
Author(s): Nenrong Liu; Rong Chen; Hongsheng Li; Jianxin Chen
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Paper Abstract

Multiphoton microscopy (MPM), a noninvasive optical method with high resolution and high sensitivity, can obtain detailed microstructures of biotissues at submolecular level. In this study, MPM is used to image microstructure varieties of human colonic mucosa and submucosa with adenocarcinoma. Some parameters, such as gland configuration, SHG/TPEF intensity ratio, and collagen orientation and so on, should serve the indicators of early colorectal cancer. The exploratory results show that it's potential for the development of multiphoton mini-endoscopy in real-time early diagnosis of colorectal cancer.

Paper Details

Date Published: 11 December 2012
PDF: 6 pages
Proc. SPIE 8553, Optics in Health Care and Biomedical Optics V, 855318 (11 December 2012); doi: 10.1117/12.999860
Show Author Affiliations
Nenrong Liu, Fujian Normal Univ. (China)
Rong Chen, Fujian Normal Univ. (China)
Hongsheng Li, Fujian Normal Univ. (China)
Jianxin Chen, Fujian Normal Univ. (China)


Published in SPIE Proceedings Vol. 8553:
Optics in Health Care and Biomedical Optics V
Qingming Luo; Ying Gu; Xingde D. Li, Editor(s)

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