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Proceedings Paper

ERK-dependent activation of Sp1 is required for low-power laser irradiation-induced vascular endothelial cell proliferation
Author(s): Jie Feng; Da Xing
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Paper Abstract

Here, we report that low-power laser irradiation (LPLI) activates ERK/Sp1 pathway to upregulate VEGF expression and promote vascular endothelial cell proliferation. We demonstrate for the first time that LPLI enhances DNA-binding activity and transactivation activity of Sp1 on VEGF promoter. Additionally, ERK translocates from cytoplasm to nucleus following LPLI. Moreover, activated ERK phosphorylates Sp1 and results in increased EKR-Sp1 interaction. Selective inhibition of Sp1 or ERK suppresses the effect of LPLI on the promotion of cell cycle progression and proliferation. These findings provide a novel link between LPLI and angiogenesis, supplying potential therapy strategies for angiogenesis with LPLI.

Paper Details

Date Published: 11 December 2012
PDF: 7 pages
Proc. SPIE 8553, Optics in Health Care and Biomedical Optics V, 855332 (11 December 2012); doi: 10.1117/12.999836
Show Author Affiliations
Jie Feng, South China Normal Univ. (China)
Da Xing, South China Normal Univ. (China)


Published in SPIE Proceedings Vol. 8553:
Optics in Health Care and Biomedical Optics V
Qingming Luo; Ying Gu; Xingde D. Li, Editor(s)

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