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Proceedings Paper

Simulating the demyelination of a nerve fiber by action potential encoded second harmonic generation
Author(s): Hong-Qin Yang; Zhihui Luo; Xinguang Chen; Yimei Huang; Shusen Xie
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Paper Abstract

Demyelination of a nerve fiber was simulated by action potential encoded second harmonic generation (SHG). The dynamics of action potential propagation along a nerve fiber with a multi-internode demyelination happening to successive internodes or intermittent internodes was studied. The results showed the attenuation and delay of action potential could obviously occur, and the refractory period increased when a nerve was demyelinated. In addition, under the same thickness and number of the demyelination, the peak of SHG signals attenuated much more along successive injured internodes than along intermittent injured internodes. It indicated that action potential encoded SHG could be a useful tool for detecting nerve demyelination.

Paper Details

Date Published: 11 December 2012
PDF: 9 pages
Proc. SPIE 8553, Optics in Health Care and Biomedical Optics V, 85530Z (11 December 2012); doi: 10.1117/12.999768
Show Author Affiliations
Hong-Qin Yang, Fujian Normal Univ. (China)
Zhihui Luo, Fujian Normal Univ. (China)
Xinguang Chen, Fujian Normal Univ. (China)
Yimei Huang, Fujian Normal Univ. (China)
Shusen Xie, Fujian Normal Univ. (China)


Published in SPIE Proceedings Vol. 8553:
Optics in Health Care and Biomedical Optics V
Qingming Luo; Ying Gu; Xingde D. Li, Editor(s)

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