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Proceedings Paper

Luminescence/magnetic resonance imaging and photodynamic therapy based on upconverting nanoparticles
Author(s): Yong Il Park; Hyung Min Kim; Jeong Hyun Kim; Kyung Chul Moon; Byeongjun Yoo; Kang Taek Lee; Soo-Young Yoon; Yung Doug Suh; Sung Ho Lee; Taeghwan Hyeon
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Paper Abstract

The luminescence and magnetic resonance imaging (MRI) and photodynamic therapy (PDT) using lanthanide-doped upconverting nanoparticles (UCNPs) is reported. With the aim to induce a therapeutic effect, a photosensitizer, chlorin e6 (Ce6), was conjugated to UCNPs. Owing to the enhanced permeability and retention effect, UCNPs combined with a photosensitizer, chlorin e6 (UCNP-Ce6) could be readily accumulated at the tumors, which could be clearly observed not only in the upconversion luminescence image but also in the MRI image. Using the energy transfer from UCNPs to Ce6, cytotoxic singlet oxygen could be generated. An in vivo PDT effect by systemic administration of UCNP-Ce6 was demonstrated under 980-nm irradiation. These results indicate that UCNP-Ce6 can be used not only as dual-modal imaging probes for accurate diagnosis but also as photodynamic therapy agent for efficient therapy.

Paper Details

Date Published: 24 October 2012
PDF: 7 pages
Proc. SPIE 8548, Nanosystems in Engineering and Medicine, 85482H (24 October 2012); doi: 10.1117/12.999411
Show Author Affiliations
Yong Il Park, Seoul National Univ. (Korea, Republic of)
Hyung Min Kim, Korea Research Institute of Chemical Technology (Korea, Republic of)
Jeong Hyun Kim, Seoul National Univ. (Korea, Republic of)
Kyung Chul Moon, Korea Univ. Ansan Hospital (Korea, Republic of)
Byeongjun Yoo, Seoul National Univ. (Korea, Republic of)
Kang Taek Lee, Korea Research Institute of Chemical Technology (Korea, Republic of)
Soo-Young Yoon, Korea Univ. Ansan Hospital (Korea, Republic of)
Yung Doug Suh, Korea Research Institute of Chemical Technology (Korea, Republic of)
Sung Ho Lee, Korea Univ. Ansan Hospital (Korea, Republic of)
Taeghwan Hyeon, Seoul National Univ. (Korea, Republic of)


Published in SPIE Proceedings Vol. 8548:
Nanosystems in Engineering and Medicine
Sang H. Choi; Jin-Ho Choy; Uhn Lee; Vijay K. Varadan, Editor(s)

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