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Proceedings Paper

Single-nanoparticle detection and spectroscopy in cells using a hyperspectral darkfield imaging technique
Author(s): Natasha Fairbairn; Rute Fernandes; Rachel Carter; Timothy J. Elliot; Antonios G. Kanaras; Otto L. Muskens
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Paper Abstract

We discuss a hyperspectral darkfield microscopy technique capable of imaging single nanoparticles at biologically compatible (<0.5 W/cm2) illumination conditions. The microscope was tested on an array of lithographically produced gold nanorod antennas and on colloidal gold nanorods deposited on a glass substrate. As a test for in-vitro imaging capabilities, we studied the uptake of gold nanorods by DC2.4 dendritic cells.

Paper Details

Date Published: 22 February 2013
PDF: 8 pages
Proc. SPIE 8595, Colloidal Nanocrystals for Biomedical Applications VIII, 859501 (22 February 2013); doi: 10.1117/12.981941
Show Author Affiliations
Natasha Fairbairn, Univ. of Southampton (United Kingdom)
Rute Fernandes, Univ. of Southampton (United Kingdom)
Rachel Carter, Univ. of Southampton (United Kingdom)
Timothy J. Elliot, Univ. of Southampton (United Kingdom)
Antonios G. Kanaras, Univ. of Southampton (United Kingdom)
Otto L. Muskens, Univ. of Southampton (United Kingdom)


Published in SPIE Proceedings Vol. 8595:
Colloidal Nanocrystals for Biomedical Applications VIII
Wolfgang J. Parak; Marek Osinski; Kenji Yamamoto, Editor(s)

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