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Proceedings Paper

Neurobiological linkage between stress and sleep
Author(s): Larry D. Sanford; Laurie L. Wellman
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Paper Abstract

Stress can have a significant negative impact on health and stress-induced alterations in sleep are implicated in both human sleep disorders and in psychiatric disorders in which sleep is affected. We have demonstrated that the amygdala, a region critical for regulating emotion, is a key modulator of sleep. Our current research is focused on understanding how the amygdala and stressful emotion affect sleep and on the role sleep plays in recovery from stress. We have implemented animal models to examine the how stress and stress-related memories impact sleep. Experiencing uncontrollable stress and reminders of uncontrollable stress can produce significant reductions in sleep, in particular rapid eye movement sleep. We are using these models to explore the neurobiology linking stress-related emotion and sleep. This research is relevant for sleep disorders such as insomnia and into mental disorders in which sleep is affected such as post-traumatic stress disorder (PTSD), which is typically characterized by a prominent sleep disturbance in the aftermath of exposure to a psychologically traumatic event.

Paper Details

Date Published: 24 October 2012
PDF: 13 pages
Proc. SPIE 8548, Nanosystems in Engineering and Medicine, 85482V (24 October 2012); doi: 10.1117/12.981788
Show Author Affiliations
Larry D. Sanford, Eastern Virginia Medical School (United States)
Laurie L. Wellman, Eastern Virginia Medical School (United States)

Published in SPIE Proceedings Vol. 8548:
Nanosystems in Engineering and Medicine
Sang H. Choi; Jin-Ho Choy; Uhn Lee; Vijay K. Varadan, Editor(s)

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