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Proceedings Paper

Photoacoustic measurement for glucose solution concentration based on tunable pulsed laser induced ultrasound
Author(s): Zhong Ren; Guodong Liu; Zhen Huang; Dengji Zhao
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Paper Abstract

Noninvasive measurement of blood glucose concentration (BGC) has become a research hotspot. BGC measurement based on photoacoustic spectroscopy (PAS) was employed to detect the photoacoustic (PA) signal of blood glucose due to the advantages of avoiding the disturbance of optical scattering. In this paper, a set of custom-built BGC measurement system based on tunable optical parametric oscillator (OPO) pulsed laser and ultrasonic transducer was established to test the PA response effect of the glucose solution. In the experiments, we successfully acquired the time resolved PA signals of distilled water and glucose aqueous solution, and the PA peak-to-peak values(PPV) were gotten under the condition of excitated pulsed laser with changed wavelength from 1340nm to 2200nm by increasing interval of 10nm, the optimal characteristic wavelengths of distilled water and glucose solution were determined. Finally, to get the concentration prediction error, we used the linear fitting of ordinary least square (OLS) algorithm to fit the PPV of 1510nm, and we got the predicted concentration error was about 0.69mmol/L via the fitted linear equation. So, this system and scheme have some values in the research of noninvasive BGC measurement.

Paper Details

Date Published: 11 December 2012
PDF: 9 pages
Proc. SPIE 8553, Optics in Health Care and Biomedical Optics V, 85532J (11 December 2012); doi: 10.1117/12.981650
Show Author Affiliations
Zhong Ren, Jiangxi Science and Technology Normal Univ. (China)
Guodong Liu, Jiangxi Science and Technology Normal Univ. (China)
Zhen Huang, Jiangxi Science and Technology Normal Univ. (China)
Dengji Zhao, Jiangxi Science and Technology Normal Univ. (China)

Published in SPIE Proceedings Vol. 8553:
Optics in Health Care and Biomedical Optics V
Qingming Luo; Ying Gu; Xingde D. Li, Editor(s)

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