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Proceedings Paper

Biocompatible multi-interaction ligands capped nanoparticles for biomedical applications
Author(s): Daishun Ling; Taeghwan Hyeon
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Paper Abstract

We developed a new generalized synthetic procedure, called as “heat-up process,” to produce uniformsized magnetite nanocrystals. We were able to synthesize uniform 11 nm-sized magnetite nanocrystals as much as 1 kilogram-scale from the thermolysis of metal-oleate complexes. Clever combination of our magnetite nanocrystals with new polymeric ligand will lead to the development of highly stable and biocompatible uniformsized nanoparticles for multifunctional nano-biomedical platforms. Such as simultaneous targeted delivery, fast diagnosis, and efficient therapy. A mussel inspired hyperbranched polymeric ligand towards surface independent nanocrystals coating was developed by us recently. The biomimetic polymeric ligand developed in our group consists of polyethylene glycol (PEG) grafted hyper-branched cationic polymer and multi-peptide domain. It contains both catechol and primary amine groups, which mimic the structure of Mussel Adhesive Protein (MAP), for chemical binding with various nanocrystals including metals, metal oxides, semiconductor nanocrystals and so on... Furthermore, the advantages of amphiphilic block copolymer ligands’ hydrophobic Van Der Waals interactions and hyper-branched chargeable polymers’ electrostatically driven effect were combined to enhance the physical interactions with the nanocrystals at the same time. This kind of polymeric ligand embodies MAP mimic surfaceindependent adhesion in nano scale to accomplish universal nanocrystals coating and the physical properties of the most nanocrystals are maintained after this polymeric ligand coating. The resulting nanoparticles are biocompatible and have high stability in aqueous solutions over long time periods, wide pH ranges, salt concentrations and thermal treatments. Also, small molecular drugs and organic fluorescent dyes can be easily incorporated or conjugated with the ligands’ primary amine groups in this system. The in vitro cell imaging, MTT assay and in vivo magnetic resonance imaging were also successfully performed by using our new ligand coated highly stable and biocompatible uniform-sized nanoparticles. We expect our highly stable and biocompatible uniform-sized nanoparticles could play a more and more important role in various biomedical applications in the near future.

Paper Details

Date Published: 24 October 2012
PDF: 6 pages
Proc. SPIE 8548, Nanosystems in Engineering and Medicine, 85481B (24 October 2012); doi: 10.1117/12.978995
Show Author Affiliations
Daishun Ling, Seoul National Univ. (Korea, Republic of)
Taeghwan Hyeon, Seoul National Univ. (Korea, Republic of)

Published in SPIE Proceedings Vol. 8548:
Nanosystems in Engineering and Medicine
Sang H. Choi; Jin-Ho Choy; Uhn Lee; Vijay K. Varadan, Editor(s)

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