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Proceedings Paper

Photodynamic Action Of Benzochlorins
Author(s): Alan R. Morgan; Greta M. Garbo; Ashraf Rampersaud; Dimitris Skalkos; Rick W. Keck; Steven H. Selman
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Paper Abstract

A series of benzochlorins have been prepared and tested for tumoricidal activity using the FANFT-induced rat bladder tumor model. Results indicate that these chlorin derivatives, in combination with red light, can cause significant tumor regression at doses as low as 0.5 - 1.0 mg/kg body weight. This compares favorably with other sensitizers tested in the same model and suggests that further studies on the effectiveness of benzochlorins in photodynamic therapy be performed.

Paper Details

Date Published: 13 June 1989
PDF: 6 pages
Proc. SPIE 1065, Photodynamic Therapy: Mechanisms, (13 June 1989); doi: 10.1117/12.978015
Show Author Affiliations
Alan R. Morgan, University of Toledo (United States)
Greta M. Garbo, University of Toledo (United States)
Ashraf Rampersaud, University of Toledo (United States)
Dimitris Skalkos, University of Toledo (United States)
Rick W. Keck, Medical College of Ohio (United States)
Steven H. Selman, Medical College of Ohio (United States)

Published in SPIE Proceedings Vol. 1065:
Photodynamic Therapy: Mechanisms
Thomas J. Dougherty, Editor(s)

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