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Proceedings Paper

The Preparation And Application Of Porphyrin-Monoclonal Antibodies For Cancer Therapy
Author(s): Kevin J. Steele; Daniel Liu; Noelle Davis; Heather Deal; Julia G. Levy
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Paper Abstract

Monoclonal antibodies with reactivity to T suppressor cells and T suppressor factors, conjugated to hematoporphyrin, when injected intravenously into mice bearing either the P815 mastocytoma or L1210 thymoma were able to reject a significant number of palpable tumors, in comparison to appropriate controls. This effect is attributed to immune modulation by selective elimination of T suppressor cells. Investigation of novel methodology for reliable linkage of photosensitizers to antibodies indicate that derivatives of polyvinyl alcohol provide suitable carriers for photosensitizers. Such carriers can relatively easily be conjugated to monoclonal antibodies without jeopardizing the biological activity of the antibody or the photosensitizer, or the solubility of the complex.

Paper Details

Date Published: 13 June 1989
PDF: 7 pages
Proc. SPIE 1065, Photodynamic Therapy: Mechanisms, (13 June 1989); doi: 10.1117/12.978006
Show Author Affiliations
Kevin J. Steele, Harvard Medical School (United States)
Daniel Liu, Quadra Logic Technologies, Inc (Canada)
Noelle Davis, University of British Columbia (Canada)
Heather Deal, University of British Columbia (Canada)
Julia G. Levy, University of British Columbia (Canada)

Published in SPIE Proceedings Vol. 1065:
Photodynamic Therapy: Mechanisms
Thomas J. Dougherty, Editor(s)

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