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Proceedings Paper

Role mediators of inflammation and cells in porphyrin-induced phototoxicity
Author(s): Henry W. Lim
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Paper Abstract

The effects of porphyrins and radiation on inflammation include activation of the complement system, generation eicosanoids from mast cells, macrophages, and endothelial cells, alteration in cutaneaous eicosanoid metabolism, activation of factor XII-dependent pathways, release of mediators from mast cells, and dermal accumulation of neutrophils. These effects contribute to the development of porphyrin-induced cutaneous inflammation, which can be seen in patients with porphyrias and as a consequence of photodynamic therapy.

Paper Details

Date Published: 13 June 1989
PDF: 6 pages
Proc. SPIE 1065, Photodynamic Therapy: Mechanisms, (13 June 1989); doi: 10.1117/12.978000
Show Author Affiliations
Henry W. Lim, NYU School of Medicine (United States)


Published in SPIE Proceedings Vol. 1065:
Photodynamic Therapy: Mechanisms
Thomas J. Dougherty, Editor(s)

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