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Proceedings Paper

Possible Implications Of Vascular Damage For Tumor Cell Inactivation In Vivo: Comparison Of Different Photosensitizers
Author(s): Barbara W. Henderson; Gwendolyn Farrell
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Paper Abstract

Various different photosensitizers were compared to Photofrin® II with respect to their potential for causing direct tumor cell inactivation and/or vascular damage. GaCl-phthalocyanine of mixed sulfonation, while being 10 x more efficient than Photofrin® II in tumor cell inactivation, caused equal vascular photosensitization. Monosulfonated AlC1-phthalocyanine, on the other hand, was sparing to the vasculature, while still exhibiting good tumor cell effects. Large differences in vascular photosensitization were also observed with tetra- and monosulfonated tetraphenylporphines.

Paper Details

Date Published: 13 June 1989
PDF: 9 pages
Proc. SPIE 1065, Photodynamic Therapy: Mechanisms, (13 June 1989); doi: 10.1117/12.977998
Show Author Affiliations
Barbara W. Henderson, Roswell Park Memorial Institute (United States)
Gwendolyn Farrell, Roswell Park Memorial Institute (United States)

Published in SPIE Proceedings Vol. 1065:
Photodynamic Therapy: Mechanisms
Thomas J. Dougherty, Editor(s)

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