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Proceedings Paper

A label-free antigen-antibody immunosensor based on a special double cladding fiber
Author(s): Wenxin Cao; Fufei Pang; Na Chen; Zhenyi Chen; Tingyun Wang
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Paper Abstract

An optical fiber label-free antigen-antibody immunosensor was proposed and demonstrated. It was fabricated by a special double cladding fiber (DCF) which presents a band-rejection resonant transmission spectrum. With the 3- aminopropyltriethoxysilane (KH-550) as the crosslink agent, goat anti rabbit IgG was immobilized on the surface of the DCF sensor. The whole process of immobilization and the antigen-antibody reaction was monitored through the shifts of the cladding mode resonant spectrum. Experimental results show that the resonant spectrum shifted toward longer wavelength during antigen-antibody reaction process. And the spectrum shift presented a saturation trend at high concentration rabbit IgG.

Paper Details

Date Published: 7 November 2012
PDF: 4 pages
Proc. SPIE 8421, OFS2012 22nd International Conference on Optical Fiber Sensors, 84215V (7 November 2012); doi: 10.1117/12.975260
Show Author Affiliations
Wenxin Cao, Shanghai Univ. (China)
Fufei Pang, Shanghai Univ. (China)
Na Chen, Shanghai Univ. (China)
Zhenyi Chen, Shanghai Univ. (China)
Tingyun Wang, Shanghai Univ. (China)

Published in SPIE Proceedings Vol. 8421:
OFS2012 22nd International Conference on Optical Fiber Sensors
Yanbiao Liao; Wei Jin; David D. Sampson; Ryozo Yamauchi; Youngjoo Chung; Kentaro Nakamura; Yunjiang Rao, Editor(s)

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