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Proceedings Paper

Medicinals Bonded To Biopolymers: Quantitative And Qualitative FTIR Determinations
Author(s): L. G. Tensmeyer; H. L . Hunter; R. Nagarajan; B. Chao; J . B. Deeter; G. A . Koppel; S. L. Briggs
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Paper Abstract

We report the successful quantitative determination of small molecules (haptens) to biomacromolecules. Results are shown for two such systems: 7-[4-chloro-3,5-dinitro-benzamido)-deacetoxycephalosporanic acid (CDNB-7-ADCA), coupled to bovine serum albumin, and polyethyleneglycol coupled to ovalbumin. In each case, the number of haptens actually bonded is considerably less than theoretically possible. We also report the successful analysis of three additional systems, but examples of their data are not shown: CDNB-7-ADCA,CDNB, and 3-[CDNB]-2-azetidinone coupled to ovalbumin. In all cases, the fact that pertinent moieties of the hapten are intact indicates that the entire hapten is intact also.

Paper Details

Date Published: 20 December 1985
PDF: 2 pages
Proc. SPIE 0553, Fourier and Computerized Infrared Spectroscopy, (20 December 1985); doi: 10.1117/12.970761
Show Author Affiliations
L. G. Tensmeyer, Lilly Corporate Center (United States)
H. L . Hunter, Lilly Corporate Center (United States)
R. Nagarajan, Lilly Corporate Center (United States)
B. Chao, Lilly Corporate Center (United States)
J . B. Deeter, Lilly Corporate Center (United States)
G. A . Koppel, Lilly Corporate Center (United States)
S. L. Briggs, Lilly Corporate Center (United States)

Published in SPIE Proceedings Vol. 0553:
Fourier and Computerized Infrared Spectroscopy
David G. Cameron; Jeannette G. Grasselli, Editor(s)

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