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Proceedings Paper

Biological And Biomedical Applications Of Fourier Transform Infrared Spectroscopy
Author(s): Michael Gendreau
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Paper Abstract

The application of infrared spectroscopy to the study of proteins and protein systems has a relatively long history when compared to other biomedical infrared applications. However, the application of infrared to studies of proteins in aqueous solutions has a much more limited history, with work beginning in the mid-1960's. Aqueous work conducted in the 1960's used conventional dispersive infrared spectrometers with limited frequency accuracy and signal-to-noise ratios, which made it very difficult to observe the weaker amide and skeletal vibrations present in the proteins and polypeptides under study. Thus, it was the common consensus of workers at that time (1) that infrared protein spectra were for all intents and purposes very similar to one another, which is in fact the case; and (2) that when working in aqueous solutions, proteins such as those found in blood would be indistinguishable due to this great similarity, which has not proven to be the case.

Paper Details

Date Published: 20 December 1985
PDF: 8 pages
Proc. SPIE 0553, Fourier and Computerized Infrared Spectroscopy, (20 December 1985); doi: 10.1117/12.970709
Show Author Affiliations
Michael Gendreau, National Center for Biomedical Infrared Spectroscopy (United States)


Published in SPIE Proceedings Vol. 0553:
Fourier and Computerized Infrared Spectroscopy
David G. Cameron; Jeannette G. Grasselli, Editor(s)

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