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Proceedings Paper

GRIN microendoscopes for high resolution in-vivo fluorescence imaging in small animals
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Paper Abstract

Intravital imaging of small animal models is a powerful technique in basic and preclinical studies. Due to the physical size of conventional microscope optics, there is a need to carry out extensive surgery procedures so as to expose tissues of an organ during each imaging session. This limits the length of time and periodicity of each imaging session for the same animal, thus results in low experimental throughput. Advancements in micro-optics and fiber optics technology have paved way in removing such physical constraints. In this study, we fabricate high quality micro-endoscope based on graded-index lenses for carrying out minimally invasive imaging procedures in live animals.

Paper Details

Date Published: 17 October 2012
PDF: 4 pages
Proc. SPIE 8421, OFS2012 22nd International Conference on Optical Fiber Sensors, 84211P (17 October 2012); doi: 10.1117/12.970382
Show Author Affiliations
Jun Ki Kim, Harvard Medical School (United States)
Korea Advanced Institute of Science and Technology (Korea, Republic of)
Seok-Hyun Yun, Harvard Medical School (United States)
Korea Advanced Institute of Science and Technology (Korea, Republic of)
Harvard-MIT Health Science and Technology (United States)


Published in SPIE Proceedings Vol. 8421:
OFS2012 22nd International Conference on Optical Fiber Sensors
Yanbiao Liao; Wei Jin; David D. Sampson; Ryozo Yamauchi; Youngjoo Chung; Kentaro Nakamura; Yunjiang Rao, Editor(s)

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