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Proceedings Paper

Quantitative Infrared Spectroscopy Of Glucose In Blood Using Partial Least-Squares Analyses
Author(s): Kenneth J. Ward; David M. Haaland; M. Ries Robinson; R. Philip Eaton
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Paper Abstract

The concentration of glucose in drawn samples of human blood has been determined using attenuated total reflectance (ATR) Fourier transform infrared (FT-IR) spectroscopy and partial least-squares (PLS) multivariate calibration. A twelve sample calibration set over the physiological glucose range of 50-400 mg/deciliter (dl) resulted in an average error of 5.24 mg/dl. These results were obtained using cross validated PLS calibration for all data in the frequency range of 950-1200 cm-1. These results are a dramatic improvement relative to those obtained by previous studies of this system using univariate peak height analyses.

Paper Details

Date Published: 1 December 1989
PDF: 2 pages
Proc. SPIE 1145, 7th Intl Conf on Fourier Transform Spectroscopy, (1 December 1989); doi: 10.1117/12.969626
Show Author Affiliations
Kenneth J. Ward, Sandia National Laboratories (United States)
David M. Haaland, Sandia National Laboratories (United States)
M. Ries Robinson, University of New Mexico Medical School (United States)
R. Philip Eaton, University of New Mexico Medical School (United States)

Published in SPIE Proceedings Vol. 1145:
7th Intl Conf on Fourier Transform Spectroscopy
David G. Cameron, Editor(s)

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