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Proceedings Paper

Comparison Of Multivariate Calibration With PCR And PLS For Glucose Using Infrared Spectra Of Human Whole Blood
Author(s): R. Marbach; H. M. Heise
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Paper Abstract

The calibration of glucose in whole EDTA blood was carried out using FT-IR spectra obtained with a micro-CIRCLE cell in the range of 1500 - 750 cm-1. The reference concentrations had been measured by the enzymatic glucose dehydrogenase method. The P-matrix approach was chosen applying the Partial-least-squares (PLS) and Principal component regression (PCR) algorithms. The optimum model for predictipns was obtained by PLS achieving an average prediction error of 19.8 mg/dL based on PRESS1 from crossvalidation. The calibration results for both algorithms are discussed. PLS is favoured on the grounds of numerical and statistical advantages.

Paper Details

Date Published: 1 December 1989
PDF: 2 pages
Proc. SPIE 1145, 7th Intl Conf on Fourier Transform Spectroscopy, (1 December 1989); doi: 10.1117/12.969537
Show Author Affiliations
R. Marbach, Institut fur Spektrochemie und angewandte Spektroskopie (Germany)
H. M. Heise, Institut fur Spektrochemie und angewandte Spektroskopie (Germany)

Published in SPIE Proceedings Vol. 1145:
7th Intl Conf on Fourier Transform Spectroscopy
David G. Cameron, Editor(s)

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