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Proceedings Paper

Fourier Transform Infrared Spectroscopy Demonstrates The Reactivity Of The Protonated Carboxyl Group Of The Acid Salt Of Calcium Bilirubinate.
Author(s): R. D. Soloway; J-G Wu; D-F Xu; Y-F Zhang; D. K. Martini; N-K Hong; R. S. Crowther
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Paper Abstract

Calcium bilirubinate is a major salt in pigment gallstones. Bilirubin IX (H2BR) is a tetrapyrrole with 1 propionic acid side chain on both the B and C rings. A striking feature is the strong intramolecular hydrogen bonding of both carboxyl groups as determined by x-ray diffraction. This greatly reduces aqueous solubility. Much less is known about the structure of the salts of calcium bilirubinate since single crystals have not been formed. One or both carboxyl groups of bilirubin may coordinate with calcium in stone, forming the acid or neutral salt.

Paper Details

Date Published: 1 December 1989
PDF: 2 pages
Proc. SPIE 1145, 7th Intl Conf on Fourier Transform Spectroscopy, (1 December 1989); doi: 10.1117/12.969451
Show Author Affiliations
R. D. Soloway, University of Texas Medical Branch (United States)
J-G Wu, Peking University (China)
D-F Xu, Sinica Academica (China)
Y-F Zhang, Jilin University (China)
D. K. Martini, University of Texas Medical Branch (United States)
N-K Hong, University of Texas Medical Branch, (United States)
R. S. Crowther, University of Texas Medical Branch (United States)

Published in SPIE Proceedings Vol. 1145:
7th Intl Conf on Fourier Transform Spectroscopy
David G. Cameron, Editor(s)

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