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Proceedings Paper

DNA detection using molecular beacon in soft-glass microstructured optical fibers
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Paper Abstract

We report, for the first time to our knowledge, the detection of specific strands of DNA based on a soft-glass microstructured optical fiber (MOF) platform loaded with molecular beacons (MBs). This detection scheme brings together the intrinsic advantage of MOF for low-volume sensing with a label-free approach, and is highly specific in identifying complementary (cDNA) from non-complementary (nDNA) sequences at room temperature. The detection limit of the current sensing scheme is demonstrated to be improvable via coupling to different sets of guided core modes by means of longitudinal offset in coupling light from the source to the fiber.

Paper Details

Date Published: 7 November 2012
PDF: 4 pages
Proc. SPIE 8421, OFS2012 22nd International Conference on Optical Fiber Sensors, 84215M (7 November 2012); doi: 10.1117/12.966847
Show Author Affiliations
Linh V. Nguyen, The Univ. of Adelaide (Australia)
Stephen C. Warren-Smith, The Univ. of Adelaide (Australia)
Alan Cooper, The Univ. of Adelaide (Australia)
Tanya M. Monro, The Univ. of Adelaide (Australia)

Published in SPIE Proceedings Vol. 8421:
OFS2012 22nd International Conference on Optical Fiber Sensors
Yanbiao Liao; Wei Jin; David D. Sampson; Ryozo Yamauchi; Youngjoo Chung; Kentaro Nakamura; Yunjiang Rao, Editor(s)

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