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Proceedings Paper

Nanometer Measurements Of Motor Protein And Membrane Glycoprotein Movements
Author(s): M. P. Sheetz; J. Gelles; E. R. Steuer; B. J. Schnapp; J. Dubinska; H. Qian; E. Elson
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Paper Abstract

The recent application of digital imaging technologies to the analysis of video images from a DIC (differential interference contrast) light microscope has given 1-2 nm precision for the measurement of movements of submicron particles at 30 Hz. [Gelles et al., Nature 331(1988)450]. This technique has been applied to the study of the movements of 1) motor proteins (kinesin and cytoplasmic dynein) on microtubules (MTs) and 2) membrane glycoproteins in cellular plasma membranes. In both cases the nanometer measurements have provided important new insights into the molecular mechanisms which govern those biological movements.

Paper Details

Date Published: 22 December 1989
PDF: 2 pages
Proc. SPIE 1161, New Methods in Microscopy and Low Light Imaging, (22 December 1989); doi: 10.1117/12.962707
Show Author Affiliations
M. P. Sheetz, Washington Univ. Med. School (United States)
J. Gelles, Washington Univ. Med. School (United States)
E. R. Steuer, Washington Univ. Med. School (United States)
B. J. Schnapp, Washington Univ. Med. School (United States)
J. Dubinska, Washington Univ. Med. School (United States)
H. Qian, Washington Univ. Med. School (United States)
E. Elson, Washington Univ. Med. School (United States)


Published in SPIE Proceedings Vol. 1161:
New Methods in Microscopy and Low Light Imaging
John E. Wampler, Editor(s)

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