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Proceedings Paper

Characterization Of Benzoporphyrin Derivative, A New Photosensitizer
Author(s): Anna Richter; Ethan Sternberg; Elizabeth Waterfield; David Dolphin; Julia G. Levy
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Paper Abstract

Benzoporphyrin derivative (BPD), synthesized from protoporphyrin and involving the formation of Diels-Alder adducts, contains four components, mono and di-acid derivatives of either ring A or ring B fused porphyrins. These compounds have been isolated and tested individually as photosensitizers both in vitro and in vivo. All forms of BPD are potent photosensiters in vitro and have a strong absorption peak at about 690 nm. 3H-BPDs were tested for biodistribution in tumor bearing mice. Distribution appeared to be similar to distribution data published by others for dihematoporphyrin ethers, with the exception that levels in skin were lower for BPD. Extraction of 3H-BPD from tissue, followed by in vitro testing of extracts for photosensitizing activity, indicated that BPD is aTly degraded in vivo. When BPDs were compared to Photofrin II for causing skin photosensitivity following intravenous administration, it was found that monoacid derivatives caused photosensitivity at 3 hours but not after 24 hours. The diacid forms did not cause appreciable skin photosensitivity even at 3 hours. Photodynamic therapy of tumors in mice with BPD showed that these compounds had comparable efficacy to Photofrin II under the experimental conditions used here.

Paper Details

Date Published: 17 March 1989
PDF: 7 pages
Proc. SPIE 0997, Advances in Photochemotherapy, (17 March 1989); doi: 10.1117/12.960196
Show Author Affiliations
Anna Richter, University of British Columbia (Canada)
Ethan Sternberg, University of British Columbia (Canada)
Elizabeth Waterfield, University of British Columbia (Canada)
David Dolphin, University of British Columbia (Canada)
Julia G. Levy, University of British Columbia (Canada)

Published in SPIE Proceedings Vol. 0997:
Advances in Photochemotherapy
Tayyaba Hasan, Editor(s)

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