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Proceedings Paper

Chemical Principles In The Design Of Improved Porphyrin Photosensitizers
Author(s): B. Franck; G. Fulling; M . Gosmann; G. Kniibel; H. Mertes; D. Schroder
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Paper Abstract

Due to the encouraging results with hematoporphyrin in photochemotherapy the porphyrin system gained predominant importance for this important medicinal application. By some convenient chemical reactions hematoporphyrin can be converted to improved derivatives, which are homogeneous, stable, and excellently soluble. Novel enlarged "porphyrinoids" with two, four, and eight additional double bonds inserted into the porphyrin ring system were synthesized. With intensive VIS absorption bands, shifted up to 300 nm to longer wave lengths compared with the normal porphyrins, these porphyrinoids may be promising for more selective and penetrating phototherapy. All the new porphyrin derivatives were shown to be efficient photosensitizers with respect to the production of singlet oxygen.

Paper Details

Date Published: 17 March 1989
PDF: 6 pages
Proc. SPIE 0997, Advances in Photochemotherapy, (17 March 1989); doi: 10.1117/12.960192
Show Author Affiliations
B. Franck, University of Munster (West Germany)
G. Fulling, University of Munster (West Germany)
M . Gosmann, University of Munster (West Germany)
G. Kniibel, University of Munster (West Germany)
H. Mertes, University of Munster (West Germany)
D. Schroder, University of Munster (West Germany)

Published in SPIE Proceedings Vol. 0997:
Advances in Photochemotherapy
Tayyaba Hasan, Editor(s)

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