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Proceedings Paper

Phototoxicity Of Rhodamine Dyes
Author(s): Christopher R. Shea; Norah Chen; Tayyaba Hasan
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Paper Abstract

Rhodamine-123 (R123) and tetrabromo-R123 (TBR) have been evaluated in vitro as potential photosensitizers. R123 localizes selectively in mitochondria of MGH-V1 bladder carcinoma cells exposed to 10 pM R123 for 30 min, and under these conditions R123 is a weak photosensitizes. Incubation with R123 for longer times enhances its phototoxicity, and is associated with a modification of its intracellular localization. TBR is approximately 100 times more phototoxic than R123, as assessed either by 3H-thymidine uptake or vital staining. Actively proliferating cells are more sensitive to either R123 or TBR phototoxicity than are plateau-phase, confluent cultures.

Paper Details

Date Published: 17 March 1989
PDF: 10 pages
Proc. SPIE 0997, Advances in Photochemotherapy, (17 March 1989); doi: 10.1117/12.960184
Show Author Affiliations
Christopher R. Shea, Harvard Medical School (United States)
Norah Chen, Harvard Medical School (United States)
Tayyaba Hasan, Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 0997:
Advances in Photochemotherapy
Tayyaba Hasan, Editor(s)

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