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Proceedings Paper

Positron Tomographic Imaging Of The Liver With Ga-68 Iron Hydroxide Colloid
Author(s): Bharath Kumar; Tom R. Miller; Barry A. Siegel; Carla J. Mathias; Joanne Markham; Gary J. Ehrhardt; Michael J. Welch
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Paper Abstract

A new radiopharmaceutical, 68Ga-iron hydroxide colloid, for hepatic imaging by positron emission tomography (PET) was prepared from the eluate of a "Ge-68Ga solvent extraction generator. In rats, 84% of the administered dose of colloid localized in the liver and 4.6% accumulated in the spleen. Initial imaging studies in normal dogs showed close correspondence of the findings by PET and transmission computed tomography (CT). PET with 68Ga-colloid was performed in 10 patients with hepatic metastases demonstrated by conventional scintigraphy with 99mTc-sulfur colloid. All focal defects noted on the conventional scintigrams were easily identified and generally seen more clearly by PET. In one patient, lesions not identified on the initial 99mTc-sulfur colloid images were demonstrated by PET. The positron tomographic images were compared with those obtained by CT in 7 patients; the two studies showed comparable findings in 5 patients, whereas PET more clearly showed multiple lesions in 2. Our results suggest that PET is a suitable technique for obtaining high-contrast, cross-sectional images of large abdominal organs. Emission computed tomography with positron-emitting radionuclides shows promise as an important new tool for clinical research (1-4). Unfortunately, wide clinical application of positron-emission tomography (PET) is presently limited by the need for an expensive, hospital-based cyclotron facility and highly trained professional and technical personnel to synthesize the radiopharmaceuticals labeled with the very short-lived radionuclides 11c, 13N, 150 and 18 F that are employed most commonly in such studies. These difficulties may be circumvented in part by the use of a simple generator system that produces the positron-emitting radionuclide 68Ga (T1/2 = 68 min) from the long-lived parent 68Ge (T1/2 = 275 days) (5-7). A large number of radiopharmaceuticals of potential clinical interest may be prepared readily from the eluate of such a generator (6,8-11). In the present study, we have prepared and characterized a new radiopharmaceutical for liver imaging, 68Ga iron hydroxide colloid, and have evaluated this agent in patients with hepatic tumors by imaging with a positron tomographic scanner.

Paper Details

Date Published: 18 August 1980
PDF: 7 pages
Proc. SPIE 0233, Application of Optical Instrumentation in Medicine VIII, (18 August 1980); doi: 10.1117/12.958930
Show Author Affiliations
Bharath Kumar, Washington University School of Medicine (United States)
Tom R. Miller, Washington University School of Medicine (United States)
Barry A. Siegel, Washington University School of Medicine (United States)
Carla J. Mathias, Washington University School of Medicine (United States)
Joanne Markham, Washington University School of Medicine (United States)
Gary J. Ehrhardt, Washington University School of Medicine (United States)
Michael J. Welch, Washington University School of Medicine (United States)

Published in SPIE Proceedings Vol. 0233:
Application of Optical Instrumentation in Medicine VIII
Joel E. Gray; William R. Hendee; Andrew G. Haus; William S. Properzio, Editor(s)

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