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Proceedings Paper

Quantitative Muscle Biopsy Analysis
Author(s): Kenneth R. Castleman; Joseph P. Van Der Meulen; T. L. Munsatt; Howard J. Frieden; Joan Higgins
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Paper Abstract

Muscle biopsy is an important tool in the diagnosis and study of neuromuscular disease. Modern histo-chemical techniques produce specimens in which the "fast" and "slow" fibers appear visibly different in color. Certain neuromuscular diseases cause the sizes and relative numbers of each fiber type to change. Neurologists use these changes to diagnose the type and severity of disease. This analysis can be either subjective, and hence of limited accuracy, or quantitative and painstakingly tedious. Working in collaboration with the University of Southern California Neurology Department, the Jet Propulsion Laboratory is developing a compact computer system to perform quantitative muscle biopsy analysis quickly and accurately. The system feeds the microscope image into the computer which then isolates and counts the fibers and measures their size. It then prints out graphs showing the size distribution for each type fiber. This information will assist physicians in diagnosing and treating muscle disease and will facilitate research aimed at understanding human muscle disease processes.

Paper Details

Date Published: 20 January 1977
PDF: 3 pages
Proc. SPIE 0089, Applications of Optics in Medicine and Biology, (20 January 1977); doi: 10.1117/12.955041
Show Author Affiliations
Kenneth R. Castleman, Jet Propulsion Laboratory (United States)
Joseph P. Van Der Meulen, USC Medical Center (United States)
T. L. Munsatt, USC Medical Center (United States)
Howard J. Frieden, Jet Propulsion Laboratory (United States)
Joan Higgins, USC Medical Center (United States)

Published in SPIE Proceedings Vol. 0089:
Applications of Optics in Medicine and Biology
Robin E. Herron, Editor(s)

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