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Proceedings Paper

Fluorescence Spectra Of Normal And Atherosclerotic Human Aorta: Optimum Discriminant Analysis
Author(s): Richard J. Crilly; Stephen Gunther; Massoud Motamedi; Ramon Berguer; J. Richard Spears
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Paper Abstract

To evaluate the usefulness of tissue fluorescence to distinguish normal from atherosclerotic regions in human arteries, we examined fluorescence spectral maps obtained over a wide range of excitation and emission wavelengths from 15 normal and 26 atherosclerotic human aorta specimens. After defining criteria to maximize safety, ease of use, reproducibility and predictive accuracy, we derived an optimum fluorescence discriminant function from this data set which reliably identifies normal and diseased arterial tissue, is independent of sampling device characteristics and vessel geometry, and utilizes simple, available methodologies. This discriminant function, the ratio of fluorescence intensity emitted at 380 nm to that emitted at 420 nm with excitation wavelength of 360 nm [I380/I420)360] compared favorably to other fluorescent discrimination techniques previously described.

Paper Details

Date Published: 15 June 1989
PDF: 6 pages
Proc. SPIE 1067, Optical Fibers in Medicine IV, (15 June 1989); doi: 10.1117/12.952109
Show Author Affiliations
Richard J. Crilly, Wayne State University of Medicine (United States)
Stephen Gunther, Wayne State University of Medicine (United States)
Massoud Motamedi, Wayne State University of Medicine (United States)
Ramon Berguer, Wayne State University of Medicine (United States)
J. Richard Spears, Wayne State University of Medicine (United States)


Published in SPIE Proceedings Vol. 1067:
Optical Fibers in Medicine IV
Abraham Katzir, Editor(s)

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