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Proceedings Paper

Laserthermia And New PDT In Neurosurgery
Author(s): T. Sakai; I. Fujishima; K. Sugiyama
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Paper Abstract

The usefulness of laserthermia using Nd:YAG laser was studied experimentally and clinically to treat deep seated brain tumor. Histological changes, temperature profile, modification of blood-brain barrier (BBB) were studied. Five patients with brain tumors were treated with laserthermia. Laserthermia using Nd:YAG laser is easy and safe to use and it is beneficial to treat deep seated brain tumor. Photodynamic therapy (PDT) was also evaluated using the photosensitizing agent pheophorbide-a (Ph-a) and an acoustic Q switched Nd:YAG laser. In xitro survival of T98G human glioma cells pretreated with Ph-a (1x10-3 mole/1 in albumin) and irradiated with a pulsed Nd:YAG laser for 5 minutes at 37.0°C was 0.4%. The present study suggested that PDT using an acoustic Q switched Nd:YAG laser and Ph-a was useful in treating experimental human glioma.

Paper Details

Date Published: 11 September 1989
PDF: 7 pages
Proc. SPIE 1066, Laser Surgery: Advanced Characterization, Therapeutics, and Systems, (11 September 1989); doi: 10.1117/12.952056
Show Author Affiliations
T. Sakai, Seirei Mikatabara General Hospital (Japan)
I. Fujishima, Seirei Mikatabara General Hospital (Japan)
K. Sugiyama, Seirei Mikatabara General Hospital (Japan)

Published in SPIE Proceedings Vol. 1066:
Laser Surgery: Advanced Characterization, Therapeutics, and Systems
Kazuhiko Atsumi; Norman R. Goldblatt; Stephen N. Joffe, Editor(s)

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