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Proceedings Paper

Studies On Laserthermia And PDT Using Nd:YAG Laser
Author(s): K. Ina; H. Tsunekawa; M. Sugihara; M. Hotta; N. Mamiya; Y. Watanabe; N. Kanemaki; K. Morise; N. Daikuzono
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Paper Abstract

Photodynamic therapy (PDT) using laser has recently been demonstrated to be applicable for cancer treatment. The combination of Pheophorbide a (Ph-a) and pulsed Nd:YAG laser irradiation has enabled us to perform PDT with the same system as used in laser hyperthermia. We have investigated this new method using human neoplastic cell lines and we calculated the survival rates after laser irradiation. Next then, in order to determine the mechanism of photochemical action we measured lipid peroxide levels of cells and lastly, demonstrated the protective effects against PDT induced by chemical scavengers. We found that pulsed Nd:YAG laser irradiation with Ph-a caused a photochmical action in cell cultures, and active oxygen spieces and/or lipid perxide were likely involved in the photodynamic process.

Paper Details

Date Published: 11 September 1989
PDF: 5 pages
Proc. SPIE 1066, Laser Surgery: Advanced Characterization, Therapeutics, and Systems, (11 September 1989); doi: 10.1117/12.952053
Show Author Affiliations
K. Ina, Meitetsu Hospital (Japan)
H. Tsunekawa, Meitetsu Hospital (Japan)
M. Sugihara, Meitetsu Hospital (Japan)
M. Hotta, Meitetsu Hospital (Japan)
N. Mamiya, Meitetsu Hospital (Japan)
Y. Watanabe, Meitetsu Hospital (Japan)
N. Kanemaki, Fujita-Gakuen Health University (Japan)
K. Morise, Nagoya University (Japan)
N. Daikuzono, Nagoya University (Japan)

Published in SPIE Proceedings Vol. 1066:
Laser Surgery: Advanced Characterization, Therapeutics, and Systems
Kazuhiko Atsumi; Norman R. Goldblatt; Stephen N. Joffe, Editor(s)

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