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Proceedings Paper

Red Blood Cell Responses To Pulsed Laser Irradiation
Author(s): Oon Tian Tan; Paul Morrison; Stephen Murray; E. F. MacNichol
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Paper Abstract

Laser parameters have recently been optimized to specifically destroy cutaneous blood vessels and at the same time, spare injury to adjacent epidermal and dermal structures such as collagen. When these parameters have been used in clinical treatmeng, it has been observed that electron-lucent spherules of 600-800 Å diameter have consistently been present in these irradiated red blood cells (RBC) producing de-st'ruction of abnormal port wine stain blood vessels. It has been postulated that these changes were due to oxygen released during laser irradiation with the implication that the oxygenated status of the blood affected. the clinical outcome. This study demonstrates that this clinically related RBC morphology is independent of the oxygenated status of the blood. Microspectrophotometric measurements of absorbance across individual RBC of laser irradiated oxygenated and deoxygenated erythrocytes as well as those rapidly heated to temperatures greater than 100°C confirm that these electron-lucent structures are due to a phase change occurring in the RBC and not to oxygen release.

Paper Details

Date Published: 11 September 1989
PDF: 11 pages
Proc. SPIE 1066, Laser Surgery: Advanced Characterization, Therapeutics, and Systems, (11 September 1989); doi: 10.1117/12.952044
Show Author Affiliations
Oon Tian Tan, Boston University Medical Center (United States)
Paul Morrison, Boston University Medical Center (United States)
Stephen Murray, Stanford University (United States)
E. F. MacNichol, Boston University School of Medicine (United States)

Published in SPIE Proceedings Vol. 1066:
Laser Surgery: Advanced Characterization, Therapeutics, and Systems
Kazuhiko Atsumi; Norman R. Goldblatt; Stephen N. Joffe, Editor(s)

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