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Proceedings Paper

Indium Labeled Platelet Deposition Following CO2 Laser Or Surgical Endarterectomy
Author(s): John H. McVicker; Arthur L. Day; James M. Seeger
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Paper Abstract

Endovascular damage from CO2, Nd:YAG, or argon laser can be considerable, causing reduced vascular biosynthesis of prostacyclin and precipitating platelet aggregation. However, the degree of platelet thrombus formation has not been directly quantified. Using Indium labeled platelets, platelet accumulation after low radiant energy CO2 laser endarterectomy was compared to accumulation after standard microsurgical endarterectomy in normal canine carotid arteries. Undisturbed adjacent segments from the same arteries served as controls. Platelet deposition (Indium activity per minute per milligram arterial tissue) was significantly greater on laser treated segments than on surgical (p=0.002) or control (p=0.002) segments. This confirms prior histologic evidence of increased acute platelet deposition after CO2 laser endarterectomy and suggests the need for further investigation of the thrombogenicity of laser angioplasty.

Paper Details

Date Published: 11 September 1989
PDF: 7 pages
Proc. SPIE 1066, Laser Surgery: Advanced Characterization, Therapeutics, and Systems, (11 September 1989); doi: 10.1117/12.952038
Show Author Affiliations
John H. McVicker, University of Florida (United States)
Arthur L. Day, University of Florida (United States)
James M. Seeger, University of Florida (United States)

Published in SPIE Proceedings Vol. 1066:
Laser Surgery: Advanced Characterization, Therapeutics, and Systems
Kazuhiko Atsumi; Norman R. Goldblatt; Stephen N. Joffe, Editor(s)

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